The Interferon (IFN) Class of Cytokines and the IFN Regulatory Factor (IRF) Transcription Factor Family

Interferons (IFNs) are a broad class of cytokines elicited on challenge to the host defense and are essential for mobilizing immune responses to pathogens. Divided into three classes, type I, type II, and type III, all IFNs share in common the ability to evoke antiviral activities initiated by the i...

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Veröffentlicht in:Cold Spring Harbor perspectives in biology Jg. 10; H. 11
Hauptverfasser: Negishi, Hideo, Taniguchi, Tadatsugu, Yanai, Hideyuki
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.11.2018
Schlagworte:
Animals
DNA
Gene Expression Regulation - physiology
Humans
Interferon Regulatory Factors - genetics
Interferon Regulatory Factors - metabolism
Interferons - genetics
Interferons - metabolism
ISSN:1943-0264, 1943-0264
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Zusammenfassung:Interferons (IFNs) are a broad class of cytokines elicited on challenge to the host defense and are essential for mobilizing immune responses to pathogens. Divided into three classes, type I, type II, and type III, all IFNs share in common the ability to evoke antiviral activities initiated by the interaction with their cognate receptors. The nine-member IFN regulatory factor (IRF) family, first discovered in the context of transcriptional regulation of type I IFN genes following viral infection, are pivotal for the regulation of the IFN responses. In this review, we briefly describe cardinal features of the three types of IFNs and then focus on the role of the IRF family members in the regulation of each IFN system.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1943-0264
1943-0264
DOI:10.1101/cshperspect.a028423