The TSC-2 product tuberin is expressed in lymphangioleiomyomatosis and angiomyolipoma
The TSC‐2 product tuberin is expressed in lymphangioleiomyomatosis and angiomyolipoma Aims: Lymphangioleiomyomatosis is categorized by proliferation of abnormal smooth muscle cells (LAM cells) in the lungs and lymphatics and the presence of angiomyolipomas. Recently mutations in the tuberous scleros...
Uložené v:
| Vydané v: | Histopathology Ročník 40; číslo 5; s. 458 - 463 |
|---|---|
| Hlavní autori: | , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
Oxford UK
Blackwell Science Ltd
01.05.2002
Blackwell |
| Predmet: | |
| ISSN: | 0309-0167, 1365-2559 |
| On-line prístup: | Získať plný text |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | The TSC‐2 product tuberin is expressed in lymphangioleiomyomatosis and angiomyolipoma
Aims: Lymphangioleiomyomatosis is categorized by proliferation of abnormal smooth muscle cells (LAM cells) in the lungs and lymphatics and the presence of angiomyolipomas. Recently mutations in the tuberous sclerosis complex‐2 gene (TSC‐2) have been described in LAM cells and angiomyolipomas. The TSC‐2 protein tuberin is a tumour suppressor and its loss may result in cellular proliferation. We used immunohistochemistry to test the hypothesis that uncontrolled cellular proliferation in lymphangioleiomyomatosis is the result of reduced tuberin protein expression.
Methods and results: Tissue from normal lung, normal kidney, lymphangioleiomyomatosis and angiomyolipomas was immunostained with three separate anti‐tuberin antibodies. Tuberin staining in normal tissues was similar to that previously described. Surprisingly, tuberin was strongly expressed in the LAM cells of all cases of lymphangioleiomyomatosis and angiomyolipoma at a greater level than in normal smooth muscle cells. The perivascular cells of angiomyolipomas, however, did not stain for tuberin.
Conclusions: Our results suggest that a loss of tuberin protein in LAM cells is not the cause of the cellular proliferation seen in lymphangioleiomyomatosis. Lymphangioleiomyomatosis may result either from the expression of a mutant tuberin with abnormal function, as a result of mutations in functionally related proteins, or from more than one mechanism. |
|---|---|
| AbstractList | The TSC‐2 product tuberin is expressed in lymphangioleiomyomatosis and angiomyolipoma
Aims: Lymphangioleiomyomatosis is categorized by proliferation of abnormal smooth muscle cells (LAM cells) in the lungs and lymphatics and the presence of angiomyolipomas. Recently mutations in the tuberous sclerosis complex‐2 gene (TSC‐2) have been described in LAM cells and angiomyolipomas. The TSC‐2 protein tuberin is a tumour suppressor and its loss may result in cellular proliferation. We used immunohistochemistry to test the hypothesis that uncontrolled cellular proliferation in lymphangioleiomyomatosis is the result of reduced tuberin protein expression.
Methods and results: Tissue from normal lung, normal kidney, lymphangioleiomyomatosis and angiomyolipomas was immunostained with three separate anti‐tuberin antibodies. Tuberin staining in normal tissues was similar to that previously described. Surprisingly, tuberin was strongly expressed in the LAM cells of all cases of lymphangioleiomyomatosis and angiomyolipoma at a greater level than in normal smooth muscle cells. The perivascular cells of angiomyolipomas, however, did not stain for tuberin.
Conclusions: Our results suggest that a loss of tuberin protein in LAM cells is not the cause of the cellular proliferation seen in lymphangioleiomyomatosis. Lymphangioleiomyomatosis may result either from the expression of a mutant tuberin with abnormal function, as a result of mutations in functionally related proteins, or from more than one mechanism. Lymphangioleiomyomatosis is categorized by proliferation of abnormal smooth muscle cells (LAM cells) in the lungs and lymphatics and the presence of angiomyolipomas. Recently mutations in the tuberous sclerosis complex-2 gene (TSC-2) have been described in LAM cells and angiomyolipomas. The TSC-2 protein tuberin is a tumour suppressor and its loss may result in cellular proliferation. We used immunohistochemistry to test the hypothesis that uncontrolled cellular proliferation in lymphangioleiomyomatosis is the result of reduced tuberin protein expression.AIMSLymphangioleiomyomatosis is categorized by proliferation of abnormal smooth muscle cells (LAM cells) in the lungs and lymphatics and the presence of angiomyolipomas. Recently mutations in the tuberous sclerosis complex-2 gene (TSC-2) have been described in LAM cells and angiomyolipomas. The TSC-2 protein tuberin is a tumour suppressor and its loss may result in cellular proliferation. We used immunohistochemistry to test the hypothesis that uncontrolled cellular proliferation in lymphangioleiomyomatosis is the result of reduced tuberin protein expression.Tissue from normal lung, normal kidney, lymphangioleiomyomatosis and angiomyolipomas was immunostained with three separate anti-tuberin antibodies. Tuberin staining in normal tissues was similar to that previously described. Surprisingly, tuberin was strongly expressed in the LAM cells of all cases of lymphangioleiomyomatosis and angiomyolipoma at a greater level than in normal smooth muscle cells. The perivascular cells of angiomyolipomas, however, did not stain for tuberin.METHODS AND RESULTSTissue from normal lung, normal kidney, lymphangioleiomyomatosis and angiomyolipomas was immunostained with three separate anti-tuberin antibodies. Tuberin staining in normal tissues was similar to that previously described. Surprisingly, tuberin was strongly expressed in the LAM cells of all cases of lymphangioleiomyomatosis and angiomyolipoma at a greater level than in normal smooth muscle cells. The perivascular cells of angiomyolipomas, however, did not stain for tuberin.Our results suggest that a loss of tuberin protein in LAM cells is not the cause of the cellular proliferation seen in lymphangioleiomyomatosis. Lymphangioleiomyomatosis may result either from the expression of a mutant tuberin with abnormal function, as a result of mutations in functionally related proteins, or from more than one mechanism.CONCLUSIONSOur results suggest that a loss of tuberin protein in LAM cells is not the cause of the cellular proliferation seen in lymphangioleiomyomatosis. Lymphangioleiomyomatosis may result either from the expression of a mutant tuberin with abnormal function, as a result of mutations in functionally related proteins, or from more than one mechanism. Lymphangioleiomyomatosis is categorized by proliferation of abnormal smooth muscle cells (LAM cells) in the lungs and lymphatics and the presence of angiomyolipomas. Recently mutations in the tuberous sclerosis complex-2 gene (TSC-2) have been described in LAM cells and angiomyolipomas. The TSC-2 protein tuberin is a tumour suppressor and its loss may result in cellular proliferation. We used immunohistochemistry to test the hypothesis that uncontrolled cellular proliferation in lymphangioleiomyomatosis is the result of reduced tuberin protein expression. Tissue from normal lung, normal kidney, lymphangioleiomyomatosis and angiomyolipomas was immunostained with three separate anti-tuberin antibodies. Tuberin staining in normal tissues was similar to that previously described. Surprisingly, tuberin was strongly expressed in the LAM cells of all cases of lymphangioleiomyomatosis and angiomyolipoma at a greater level than in normal smooth muscle cells. The perivascular cells of angiomyolipomas, however, did not stain for tuberin. Our results suggest that a loss of tuberin protein in LAM cells is not the cause of the cellular proliferation seen in lymphangioleiomyomatosis. Lymphangioleiomyomatosis may result either from the expression of a mutant tuberin with abnormal function, as a result of mutations in functionally related proteins, or from more than one mechanism. The TSC‐2 product tuberin is expressed in lymphangioleiomyomatosis and angiomyolipoma Aims : Lymphangioleiomyomatosis is categorized by proliferation of abnormal smooth muscle cells (LAM cells) in the lungs and lymphatics and the presence of angiomyolipomas. Recently mutations in the tuberous sclerosis complex‐2 gene (TSC‐2) have been described in LAM cells and angiomyolipomas. The TSC‐2 protein tuberin is a tumour suppressor and its loss may result in cellular proliferation. We used immunohistochemistry to test the hypothesis that uncontrolled cellular proliferation in lymphangioleiomyomatosis is the result of reduced tuberin protein expression. Methods and results : Tissue from normal lung, normal kidney, lymphangioleiomyomatosis and angiomyolipomas was immunostained with three separate anti‐tuberin antibodies. Tuberin staining in normal tissues was similar to that previously described. Surprisingly, tuberin was strongly expressed in the LAM cells of all cases of lymphangioleiomyomatosis and angiomyolipoma at a greater level than in normal smooth muscle cells. The perivascular cells of angiomyolipomas, however, did not stain for tuberin. Conclusions : Our results suggest that a loss of tuberin protein in LAM cells is not the cause of the cellular proliferation seen in lymphangioleiomyomatosis. Lymphangioleiomyomatosis may result either from the expression of a mutant tuberin with abnormal function, as a result of mutations in functionally related proteins, or from more than one mechanism. |
| Author | Knox, A J Tattersfield, A E Ronan, J Clelland, C A Johnson, S R |
| Author_xml | – sequence: 1 givenname: S R surname: Johnson fullname: Johnson, S R organization: Division of Therapeutics, University of Nottingham, UK – sequence: 2 givenname: C A surname: Clelland fullname: Clelland, C A organization: Department of Histopathology, City Hospital, Nottingham, UK – sequence: 3 givenname: J surname: Ronan fullname: Ronan, J organization: Department of Histopathology, City Hospital, Nottingham, UK – sequence: 4 givenname: A E surname: Tattersfield fullname: Tattersfield, A E organization: Division of Respiratory Medicine, University of Nottingham, UK – sequence: 5 givenname: A J surname: Knox fullname: Knox, A J organization: Division of Respiratory Medicine, University of Nottingham, UK |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13912135$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/12010366$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkU9v0zAAxS00xLrBV0C5wC2Z_yc-gMQq2KYNkFgnJC6WYzvMJYkzOxHtt8dZS5G4wMGy_fx7z5bfCTjqfW8ByBAsEKT8bF0gwlmOGRMFhhAXEBFBi80TsDgcHIEFJFDkEPHyGJzEuIYQlQTjZ-AYYYgg4XwB7lb3NlvdLnOcDcGbSY_ZONU2uD5zMbObIdgYrcnSvt12w73qvzvfWue7re_U6GOiVG-yRz1prRuS_hw8bVQb7Yv9fAruPrxfLS_zm88XV8t3N7mmQtC8VNoIYaxp6gqbmtacYGVU1WgmuGoUNAxZxmrNqjRE4mBZKlZhizmlVU1Owetdbnr7w2TjKDsXtW1b1Vs_RVkiXmFKRAJf7sGp7qyRQ3CdClv5-yMS8GoPqKhV2wTVaxf_cEQgjAhL3Nsdp4OPMdhGajeq0fl-DMq1EkE5NyTXci5CzkXIuSH52JDcpIDqr4DDHf-2vtlZf7rWbv_bJy-vbudV8uc7v4uj3Rz8KvyQvCQlk18_XUiGPp5fn3_7Iin5BcwquDI |
| CitedBy_id | crossref_primary_10_3390_ijms21093151 crossref_primary_10_1371_journal_pone_0126025 crossref_primary_10_1158_0008_5472_CAN_06_1122 crossref_primary_10_1158_0008_5472_CAN_15_1287 crossref_primary_10_1196_annals_1413_015 crossref_primary_10_1046_j_1320_5463_2003_01460_x crossref_primary_10_1148_rg_253055006 crossref_primary_10_1016_j_ccm_2004_05_003 crossref_primary_10_1097_00000478_200412000_00017 crossref_primary_10_1164_rccm_202104_0872ED |
| Cites_doi | 10.1086/301804 10.1136/thx.54.3.254 10.1073/pnas.97.11.6085 10.1074/jbc.272.46.29301 10.1038/ng0294-193 10.1152/ajplung.1999.277.6.L1109 10.1164/ajrccm.164.8.2104095 10.1165/ajrcmb.21.3.3693 |
| ContentType | Journal Article |
| Copyright | 2002 INIST-CNRS |
| Copyright_xml | – notice: 2002 INIST-CNRS |
| DBID | BSCLL AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1046/j.1365-2559.2002.01394.x |
| DatabaseName | Istex CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE CrossRef |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1365-2559 |
| EndPage | 463 |
| ExternalDocumentID | 12010366 13912135 10_1046_j_1365_2559_2002_01394_x HIS1394 ark_67375_WNG_51MBKBZR_4 |
| Genre | article Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- .3N .55 .GA .GJ .Y3 05W 0R~ 10A 1OB 1OC 29I 31~ 33P 36B 3SF 3UE 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHQN AAIPD AAKAS AAMMB AAMNL AANHP AANLZ AAONW AASGY AAXRX AAYCA AAZKR ABCQN ABCUV ABDBF ABEML ABJNI ABOCM ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCZN ACGFO ACGFS ACGOF ACIWK ACMXC ACPOU ACPRK ACRPL ACSCC ACUHS ACXBN ACXQS ACYXJ ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADNMO ADOZA ADXAS ADZCM ADZMN AEFGJ AEGXH AEIGN AEIMD AENEX AEUYR AEYWJ AFBPY AFEBI AFFNX AFFPM AFGKR AFWVQ AFZJQ AGHNM AGQPQ AGXDD AGYGG AHBTC AHEFC AIACR AIAGR AIDQK AIDYY AIQQE AITYG AIURR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BSCLL BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DC6 DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 EAD EAP EBC EBD EBS EJD EMB EMK EMOBN ESX EX3 F00 F01 F04 F5P FEDTE FUBAC FZ0 G-S G.N GODZA GSXLS H.X HF~ HGLYW HVGLF HZI HZ~ IHE IX1 J0M J5H K48 KBYEO L7B LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OIG OVD P2P P2W P2X P2Z P4B P4D PALCI Q.N Q11 QB0 R.K RIWAO RJQFR ROL RX1 SAMSI SUPJJ SV3 TEORI TUS UB1 V8K W8V W99 WBKPD WH7 WHWMO WIH WIJ WIK WOHZO WOW WQJ WVDHM WXI WXSBR X7M XG1 Y6R YFH YOC YUY ZGI ZXP ZZTAW ~IA ~WT AAYXX CITATION O8X IQODW AAHHS ACCFJ ADZOD AEEZP AEQDE AEUQT AFPWT AIWBW AJBDE CGR CUY CVF ECM EIF NPM WRC WUP 7X8 |
| ID | FETCH-LOGICAL-c4994-7acd99dedfb82db4b632ada8fc596afa0d51e55bc58bc59edf077a582e26448b3 |
| IEDL.DBID | DRFUL |
| ISICitedReferencesCount | 12 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000175564400004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0309-0167 |
| IngestDate | Wed Oct 01 11:55:40 EDT 2025 Wed Feb 19 02:34:14 EST 2025 Mon Jul 21 09:15:46 EDT 2025 Tue Nov 18 22:32:13 EST 2025 Sat Nov 29 04:10:07 EST 2025 Sun Sep 21 06:19:51 EDT 2025 Sun Sep 21 06:18:06 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Keywords | Kidney disease Diffuse Human Immunohistochemistry Lung disease Lymphangiomatosis Urinary system disease Respiratory disease Leiomyomata Gene expression Carcinogenesis Bronchopulmonary Kidney Pathology Gene Tuberin Bronchus disease Benign neoplasm Angiomyolipoma Mutation Bourneville syndrome Tumor suppressor gene |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4994-7acd99dedfb82db4b632ada8fc596afa0d51e55bc58bc59edf077a582e26448b3 |
| Notes | ark:/67375/WNG-51MBKBZR-4 istex:DF4CE1CC4EA3581CAAEDD1B13F666CFB77764B37 ArticleID:HIS1394 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 12010366 |
| PQID | 71682439 |
| PQPubID | 23479 |
| PageCount | 6 |
| ParticipantIDs | proquest_miscellaneous_71682439 pubmed_primary_12010366 pascalfrancis_primary_13912135 crossref_citationtrail_10_1046_j_1365_2559_2002_01394_x crossref_primary_10_1046_j_1365_2559_2002_01394_x wiley_primary_10_1046_j_1365_2559_2002_01394_x_HIS1394 istex_primary_ark_67375_WNG_51MBKBZR_4 |
| PublicationCentury | 2000 |
| PublicationDate | May 2002 |
| PublicationDateYYYYMMDD | 2002-05-01 |
| PublicationDate_xml | – month: 05 year: 2002 text: May 2002 |
| PublicationDecade | 2000 |
| PublicationPlace | Oxford UK |
| PublicationPlace_xml | – name: Oxford UK – name: Oxford – name: England |
| PublicationTitle | Histopathology |
| PublicationTitleAlternate | Histopathology |
| PublicationYear | 2002 |
| Publisher | Blackwell Science Ltd Blackwell |
| Publisher_xml | – name: Blackwell Science Ltd – name: Blackwell |
| References | Henske EP, Wessner LL, Golden J et al. Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two hit model for the pathogenesis of tuberous sclerosis tumours. Am. J. Pathol. 1997; 151 ; 1639-1647. Green AJ, Smith M, Yates JRW. Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients. Nature Genet. 1994; 6 ; 193-196. Johnson SR, Knox AJ. Autocrine production of matrix metalloproteinase-2 is required for human airway smooth muscle proliferation. Am. J. Physiol. (Lung Cell Mol. Physiol.) 1999; 277 ; L1109-L1117. Soucek T, Pusch O, Wienecke R et al. Role of the tuberous sclerosis gene-2 product in cell cycle control. J. Biol. Chem. 1997; 272 ; 29301-29308. Smolarek TA, Wessner LL, McCormack FX et al. Evidence that lymphangioleiomyomatosis is caused by TSC2 mutations: chromosome 16p13 loss of heterozygosity in angiomyolipomas and lymph nodes from women with lymphangiomyomatosis Am. J. Hum. Genet. 1998; 62 ; 810810. Yu J, Astrinidis A, Henske EP. Chromosome 16 loss of heterozygosity in tuberous sclerosis and sporadic lymphangiomyomatosis. Am. J. Respir. Crit. Care Med. 2001; 164 ; 1537-1540. Johnson SR. Lymphangioleiomyomatosis: clinical features, management and basic mechanisms Thorax 1999; 54 ; 254-264. Wienecke R, Maize JC Jr, Shoarinejad F et al. Co-localization of the TSC2 product tuberin with its target Rap1 in the Golgi apparatus. Oncogene 1996; 13 ; 913-923. Valensi QJ. Pulmonary lymphangiomyoma, a probable forme fruste of tuberous sclerosis. Am. Rev. Respir. Dis. 1973; 108 ; 1411-1415. Plank TL, Logginidou H, Klein-Szanto A, Henske EP. The expression of hamartin, the product of the TSC1 gene, in normal human tissues and in TSC1- and TSC2-linked angiomyolipomas. Mod. Pathol. 1999; 12 ; 539-545. Matsumoto Y, Horiba K, Usuki J et al. Markers of cell proliferation and expression of melanosomal antigen in lymphangioleiomyomatosis. Am. J. Respir. Cell Mol. Biol. 1999; 21 ; 327-336. Carsillo T, Astrinidis A, Henske EP. Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis. Proc. Natl Acad. Sci. USA 2000; 97 ; 6085-6090. 1999; 12 1999; 54 1999; 21 2001; 164 1999; 277 1973; 108 1998; 62 1996; 13 1997; 151 1997; 272 1994; 6 2000; 97 Wienecke R (e_1_2_6_8_2) 1996; 13 Plank TL (e_1_2_6_11_2) 1999; 12 e_1_2_6_7_2 Henske EP (e_1_2_6_9_2) 1997; 151 Valensi QJ (e_1_2_6_3_2) 1973; 108 e_1_2_6_4_2 e_1_2_6_6_2 e_1_2_6_5_2 e_1_2_6_12_2 e_1_2_6_13_2 e_1_2_6_2_2 e_1_2_6_10_2 |
| References_xml | – reference: Yu J, Astrinidis A, Henske EP. Chromosome 16 loss of heterozygosity in tuberous sclerosis and sporadic lymphangiomyomatosis. Am. J. Respir. Crit. Care Med. 2001; 164 ; 1537-1540. – reference: Plank TL, Logginidou H, Klein-Szanto A, Henske EP. The expression of hamartin, the product of the TSC1 gene, in normal human tissues and in TSC1- and TSC2-linked angiomyolipomas. Mod. Pathol. 1999; 12 ; 539-545. – reference: Henske EP, Wessner LL, Golden J et al. Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two hit model for the pathogenesis of tuberous sclerosis tumours. Am. J. Pathol. 1997; 151 ; 1639-1647. – reference: Valensi QJ. Pulmonary lymphangiomyoma, a probable forme fruste of tuberous sclerosis. Am. Rev. Respir. Dis. 1973; 108 ; 1411-1415. – reference: Carsillo T, Astrinidis A, Henske EP. Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis. Proc. Natl Acad. Sci. USA 2000; 97 ; 6085-6090. – reference: Johnson SR, Knox AJ. Autocrine production of matrix metalloproteinase-2 is required for human airway smooth muscle proliferation. Am. J. Physiol. (Lung Cell Mol. Physiol.) 1999; 277 ; L1109-L1117. – reference: Green AJ, Smith M, Yates JRW. Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients. Nature Genet. 1994; 6 ; 193-196. – reference: Soucek T, Pusch O, Wienecke R et al. Role of the tuberous sclerosis gene-2 product in cell cycle control. J. Biol. Chem. 1997; 272 ; 29301-29308. – reference: Wienecke R, Maize JC Jr, Shoarinejad F et al. Co-localization of the TSC2 product tuberin with its target Rap1 in the Golgi apparatus. Oncogene 1996; 13 ; 913-923. – reference: Smolarek TA, Wessner LL, McCormack FX et al. Evidence that lymphangioleiomyomatosis is caused by TSC2 mutations: chromosome 16p13 loss of heterozygosity in angiomyolipomas and lymph nodes from women with lymphangiomyomatosis Am. J. Hum. Genet. 1998; 62 ; 810810. – reference: Matsumoto Y, Horiba K, Usuki J et al. Markers of cell proliferation and expression of melanosomal antigen in lymphangioleiomyomatosis. Am. J. Respir. Cell Mol. Biol. 1999; 21 ; 327-336. – reference: Johnson SR. Lymphangioleiomyomatosis: clinical features, management and basic mechanisms Thorax 1999; 54 ; 254-264. – volume: 97 start-page: 6085 year: 2000 end-page: 6090 article-title: Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis publication-title: Proc. Natl Acad. Sci. USA – volume: 62 start-page: 810 year: 1998 end-page: 810 article-title: Evidence that lymphangioleiomyomatosis is caused by TSC2 mutations: chromosome 16p13 loss of heterozygosity in angiomyolipomas and lymph nodes from women with lymphangiomyomatosis publication-title: Am. J. Hum. Genet. – volume: 108 start-page: 1411 year: 1973 end-page: 1415 article-title: Pulmonary lymphangiomyoma, a probable forme fruste of tuberous sclerosis publication-title: Am. Rev. Respir. Dis. – volume: 21 start-page: 327 year: 1999 end-page: 336 article-title: Markers of cell proliferation and expression of melanosomal antigen in lymphangioleiomyomatosis publication-title: Am. J. Respir. Cell Mol. Biol. – volume: 164 start-page: 1537 year: 2001 end-page: 1540 article-title: Chromosome 16 loss of heterozygosity in tuberous sclerosis and sporadic lymphangiomyomatosis publication-title: Am. J. Respir. Crit. Care Med. – volume: 277 start-page: L1109 year: 1999 end-page: L1117 article-title: Autocrine production of matrix metalloproteinase‐2 is required for human airway smooth muscle proliferation publication-title: Am. J. Physiol. (Lung Cell Mol. Physiol.) – volume: 272 start-page: 29301 year: 1997 end-page: 29308 article-title: Role of the tuberous sclerosis gene‐2 product in cell cycle control publication-title: J. Biol. Chem. – volume: 54 start-page: 254 year: 1999 end-page: 264 article-title: Lymphangioleiomyomatosis: clinical features, management and basic mechanisms publication-title: Thorax – volume: 13 start-page: 913 year: 1996 end-page: 923 article-title: Co‐localization of the TSC2 product tuberin with its target Rap1 in the Golgi apparatus publication-title: Oncogene – volume: 151 start-page: 1639 year: 1997 end-page: 1647 article-title: Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two hit model for the pathogenesis of tuberous sclerosis tumours publication-title: Am. J. Pathol. – volume: 12 start-page: 539 year: 1999 end-page: 545 article-title: The expression of hamartin, the product of the TSC1 gene, in normal human tissues and in TSC1‐ and TSC2‐linked angiomyolipomas publication-title: Mod. Pathol. – volume: 6 start-page: 193 year: 1994 end-page: 196 article-title: Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients publication-title: Nature Genet. – ident: e_1_2_6_5_2 doi: 10.1086/301804 – ident: e_1_2_6_2_2 doi: 10.1136/thx.54.3.254 – volume: 12 start-page: 539 year: 1999 ident: e_1_2_6_11_2 article-title: The expression of hamartin, the product of the TSC1 gene, in normal human tissues and in TSC1‐ and TSC2‐linked angiomyolipomas publication-title: Mod. Pathol. – volume: 151 start-page: 1639 year: 1997 ident: e_1_2_6_9_2 article-title: Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two hit model for the pathogenesis of tuberous sclerosis tumours publication-title: Am. J. Pathol. – volume: 108 start-page: 1411 year: 1973 ident: e_1_2_6_3_2 article-title: Pulmonary lymphangiomyoma, a probable forme fruste of tuberous sclerosis publication-title: Am. Rev. Respir. Dis. – ident: e_1_2_6_6_2 doi: 10.1073/pnas.97.11.6085 – ident: e_1_2_6_10_2 doi: 10.1074/jbc.272.46.29301 – volume: 13 start-page: 913 year: 1996 ident: e_1_2_6_8_2 article-title: Co‐localization of the TSC2 product tuberin with its target Rap1 in the Golgi apparatus publication-title: Oncogene – ident: e_1_2_6_4_2 doi: 10.1038/ng0294-193 – ident: e_1_2_6_7_2 doi: 10.1152/ajplung.1999.277.6.L1109 – ident: e_1_2_6_13_2 doi: 10.1164/ajrccm.164.8.2104095 – ident: e_1_2_6_12_2 doi: 10.1165/ajrcmb.21.3.3693 |
| SSID | ssj0017322 |
| Score | 1.7232653 |
| Snippet | The TSC‐2 product tuberin is expressed in lymphangioleiomyomatosis and angiomyolipoma
Aims: Lymphangioleiomyomatosis is categorized by proliferation of... The TSC‐2 product tuberin is expressed in lymphangioleiomyomatosis and angiomyolipoma Aims : Lymphangioleiomyomatosis is categorized by proliferation of... Lymphangioleiomyomatosis is categorized by proliferation of abnormal smooth muscle cells (LAM cells) in the lungs and lymphatics and the presence of... |
| SourceID | proquest pubmed pascalfrancis crossref wiley istex |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 458 |
| SubjectTerms | Adult Aged angiomyolipoma Angiomyolipoma - metabolism Angiomyolipoma - pathology Biological and medical sciences Female Humans Immunohistochemistry Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Kidneys Lung Neoplasms - metabolism Lung Neoplasms - pathology lymphangioleiomyomatosis Lymphangioleiomyomatosis - metabolism Lymphangioleiomyomatosis - pathology Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Pneumology Repressor Proteins - biosynthesis tuberin tuberous sclerosis Tuberous Sclerosis Complex 2 Protein Tumor Suppressor Proteins Tumors of the respiratory system and mediastinum Tumors of the urinary system tumour suppressor |
| Title | The TSC-2 product tuberin is expressed in lymphangioleiomyomatosis and angiomyolipoma |
| URI | https://api.istex.fr/ark:/67375/WNG-51MBKBZR-4/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1046%2Fj.1365-2559.2002.01394.x https://www.ncbi.nlm.nih.gov/pubmed/12010366 https://www.proquest.com/docview/71682439 |
| Volume | 40 |
| WOSCitedRecordID | wos000175564400004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVWIB databaseName: Wiley Online Library customDbUrl: eissn: 1365-2559 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017322 issn: 0309-0167 databaseCode: DRFUL dateStart: 19970101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lj9MwELagRYgL74XwKDkgblklcZzHkV0oi2ArtA9txcUaOzaqKEnVtKh74yfwG_klzDhpq0p7WCEOkRLLk8dkHH-T-TzD2GuBU0xhdBFYUaKDgog4UCLlgTWWh6CMtTZxxSay0Sgfj4svHf-J1sK0-SE2P9xoZLjvNQ1wUG0VktBlt10ztBASO6bBPoGZZB_xZD9GMxY91n93Mjz_vIkpZHwbUyDyfcfr6WKcV55rZ7Lqk95XRJ6EBvVn28IXVyHTXaDrZqrhvf_5jPfZ3Q6v-m9bA3vAbpjqIbt93EXkH7ELtDP_7PTwz6_fsT9r08f6i6WiVYX-pPHNyjFtTenj8fQSbQeqb0QGmNQ_LmuEy3WDvaAqfdeObdPJDNsfs_Ph-7PDo6Ar1hDohNILZ6DLoihNaVUelypRKY-hhNxqUaRgISxFZIRQWuS4FdgvzDIQeWyci6j4HutVdWWeMj_JQQiIYp2DTQBCxW3KI6EtB_SGQHssW78VqbtM5lRQYypdRD2h1WekN0l6ozqbsXR6kyuPRRvJWZvN4xoyb9yL3wjA_Dux4TIhL0YfpIiODz4dfD2RiccGO5axvQIvKHGe8NirtalIHMQUmYHK1MtGotOaxwgNPfaktaCtLLEVeJp6LHWGcu3blkcfT2nv2b8KPmd3XOUbR-58wXqL-dK8ZLf0z8WkmQ_YzWycD7oh9hcNICPa |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9NAEB6hBgEX3g_zaH1A3Fxir9ePIy2EVE0i1KZqxWW1Xu-iiGBHcYLSGz-B38gvYWa9TRSphwpxiOSsPEk8_ib7refbGYC3HKeYXKs8MLzEBQoy4qDgCQuMNqwrC22MiW2ziXQ0yi4u8i-uHRDthWnrQ6wfuFFk2P9rCnB6IP3epSXbKLcSLeTEVmqwT2wm3kdC2YkRVQj3zseT3tlgnVRI2SapQOp7J-xxSc5rP2trtuqQ41eknpQNOtC0nS-uo6bbTNdOVb0H__UiH8J9x1j9Dy3EHsEtXT2GO0OXk38C54g0f3x6-OfX78iftQVk_cWyoH2F_qTx9cpqbXXp4_vpJaJHVt9IDjCpf1zWSJjrBs-SVenbcRybTmY4_hTOep_Gh_3AtWsIVEwFhlOpyjwvdWmKLCqLuEhYJEuZGcXzRBrZLXmoOS8Uz_CV43ndNJU8i7RdJBbsGexUdaVfgB9nknMZRiqTJpayWzCTsJArwySuh6TyIL26LUK5WubUUmMqbE49pv1n5DdBfqNOm5GwfhMrD8K15ayt53EDm3f2zq8N5Pw76eFSLs5HnwUPhwfHB19PROzB7hY0Nt_Aciqdxz3Yu8KKwDCm3IysdL1sBC5bswjJoQfPWwhtbEmvwJLEg8Qi5cY_W_SPTuno5b8a7sHd_ng4EIOj0fEruGf74Fip52vYWcyX-g3cVj8Xk2a-6yLtL6qRJuI |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3JbtswEB0UdhH00qa7uiQ6FL0ptURRy7FZ3ARJjCALEvRCUFwKo65kWHbh3PoJ-cZ8SWcoxYaBHIKiBwESodEynBEfNY8zAJ84DjG5UXlgucYJCiLioOAJC6yxrCcLY62NXbGJdDDIrq7yk7YcEK2FafJDLH64kWe47zU5uBlr-6UNSzZe7ihaiIkd1WCL0Ey8hYCyG1NNmQ50d0_7F0eLoELKlkEFYt-3xJ42yHnvtVZGqy4pfk7sSVmjAm1T-eI-aLqKdN1Q1X_2X19yHZ62iNX_2pjYc3hkyhewdtzG5F_CJVqaf362c_vnJvLHTQJZfzoraF2hP6x9M3dcW6N9PB5do_XI8gfRAYbVr-sKAXNV41my1L5rx7bRcIztr-Civ3e-sx-05RoCFVOC4VQqnefaaFtkkS7iImGR1DKzCntDWtnTPDScF4pnuOV4Xi9NJc8i4yaJBXsNnbIqzVvw40xyLsNIZdLGUvYKZhMWcmWZxPmQVB6kd90iVJvLnEpqjISLqce0_oz0JkhvVGkzEk5vYu5BuJAcN_k8HiDz2fX8QkBOfhIfLuXicvBN8PB4-3D7-6mIPdhYMY3lHVhOqfO4B5t3tiLQjSk2I0tTzWqB09YsQnDowZvGhJayxFdgSeJB4izlwY8t9g_OaO_dvwpuwtrJbl8cHQwO38MTVwbHMT0_QGc6mZmP8Fj9ng7ryUbraH8B_BAmXQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+TSC%E2%80%902+product+tuberin+is+expressed+in+lymphangioleiomyomatosis+and+angiomyolipoma&rft.jtitle=Histopathology&rft.au=Johnson%2C+S+R&rft.au=Clelland%2C+C+A&rft.au=Ronan%2C+J&rft.au=Tattersfield%2C+A+E&rft.date=2002-05-01&rft.issn=0309-0167&rft.eissn=1365-2559&rft.volume=40&rft.issue=5&rft.spage=458&rft.epage=463&rft_id=info:doi/10.1046%2Fj.1365-2559.2002.01394.x&rft.externalDBID=n%2Fa&rft.externalDocID=10_1046_j_1365_2559_2002_01394_x |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0309-0167&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0309-0167&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0309-0167&client=summon |