The occurrence of shivering in cardiac arrest survivors undergoing therapeutic hypothermia is associated with a good neurologic outcome

The incidence of shivering in cardiac arrest survivors who undergo therapeutic hypothermia (TH) is varied. Its occurrence is dependent on the integrity of multiple peripheral and central neurologic pathways. We hypothesized that cardiac arrest survivors who develop shivering while undergoing TH are...

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Published in:Resuscitation Vol. 84; no. 5; pp. 626 - 629
Main Authors: Nair, Sanjeev U., Lundbye, Justin B.
Format: Journal Article
Language:English
Published: Ireland Elsevier Ireland Ltd 01.05.2013
Subjects:
Adult
Aged
Cardiac arrest
Emergency
Female
Heart Arrest - complications
Heart Arrest - therapy
Humans
Hypothermia, Induced - adverse effects
Hypothermia, Induced - methods
Logistic Models
Male
Middle Aged
Neurologic Examination
Neurologic outcome
Retrospective Studies
Shivering
Survival Analysis
Survivors
Therapeutic hypothermia
Treatment Outcome
Therapeutic hypothermia
Shivering
Cardiac arrest
Neurologic outcome
ISSN:0300-9572, 1873-1570, 1873-1570
Online Access:Get full text
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Summary:The incidence of shivering in cardiac arrest survivors who undergo therapeutic hypothermia (TH) is varied. Its occurrence is dependent on the integrity of multiple peripheral and central neurologic pathways. We hypothesized that cardiac arrest survivors who develop shivering while undergoing TH are more likely to have intact central neurologic pathways and thus have better neurologic outcome as compared to those who do not develop shivering during TH. Prospectively collected data on consecutive adult patients admitted to a tertiary center from 1/1/2007 to 11/1/2010 that survived a cardiac arrest and underwent TH were retrospectively analyzed. Patients who developed shivering during the cooling phase of TH formed the “shivering” group and those that did not formed the “non-shivering” group. The primary end-point: Pittsburgh Cerebral Performance Category (CPC) scale; good (CPC 1–2) or poor (CPC 3–5) neurological outcome prior to discharge from hospital. Of the 129 cardiac arrest survivors who underwent TH, 34/94 (36%) patients in the “non-shivering” group as compared to 21/35 (60%) patients in the “shivering” group had good neurologic outcome (P=0.02). After adjusting for confounders using binary logistic regression, occurrence of shivering (OR: 2.71, 95% CI 1.099–7.41, P=0.04), time to return of spontaneous circulation (OR: 0.96, 95% CI 0.93–0.98, P=0.004) and initial presenting rhythm (OR: 4.0, 95% CI 1.63–10.0, P=0.002) were independent predictors of neurologic outcome. The occurrence of shivering in cardiac arrest survivors who undergo TH is associated with an increased likelihood of good neurologic outcome as compared to its absence.
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ISSN:0300-9572
1873-1570
1873-1570
DOI:10.1016/j.resuscitation.2012.11.018