Influenza A Virus Migration and Persistence in North American Wild Birds

Wild birds have been implicated in the emergence of human and livestock influenza. The successful prediction of viral spread and disease emergence, as well as formulation of preparedness plans have been hampered by a critical lack of knowledge of viral movements between different host populations. T...

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Vydáno v:PLoS pathogens Ročník 9; číslo 8; s. e1003570
Hlavní autoři: Bahl, Justin, Krauss, Scott, Kühnert, Denise, Fourment, Mathieu, Raven, Garnet, Pryor, S. Paul, Niles, Lawrence J., Danner, Angela, Walker, David, Mendenhall, Ian H., Su, Yvonne C. F., Dugan, Vivien G., Halpin, Rebecca A., Stockwell, Timothy B., Webby, Richard J., Wentworth, David E., Drummond, Alexei J., Smith, Gavin J. D., Webster, Robert G.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Public Library of Science 01.08.2013
Public Library of Science (PLoS)
Témata:
Animal Migration
Animal populations
Animals
Avian flu
Bird migration
Charadriiformes - virology
Colleges & universities
Confidence intervals
Humans
Influenza A virus
Influenza in Birds - epidemiology
Influenza in Birds - transmission
Livestock
Models, Biological
North America - epidemiology
Pandemics
Trees
Viruses
North America
ISSN:1553-7374, 1553-7366, 1553-7374
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Shrnutí:Wild birds have been implicated in the emergence of human and livestock influenza. The successful prediction of viral spread and disease emergence, as well as formulation of preparedness plans have been hampered by a critical lack of knowledge of viral movements between different host populations. The patterns of viral spread and subsequent risk posed by wild bird viruses therefore remain unpredictable. Here we analyze genomic data, including 287 newly sequenced avian influenza A virus (AIV) samples isolated over a 34-year period of continuous systematic surveillance of North American migratory birds. We use a Bayesian statistical framework to test hypotheses of viral migration, population structure and patterns of genetic reassortment. Our results reveal that despite the high prevalence of Charadriiformes infected in Delaware Bay this host population does not appear to significantly contribute to the North American AIV diversity sampled in Anseriformes. In contrast, influenza viruses sampled from Anseriformes in Alberta are representative of the AIV diversity circulating in North American Anseriformes. While AIV may be restricted to specific migratory flyways over short time frames, our large-scale analysis showed that the long-term persistence of AIV was independent of bird flyways with migration between populations throughout North America. Analysis of long-term surveillance data provides vital insights to develop appropriately informed predictive models critical for pandemic preparedness and livestock protection.
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Conceived and designed the experiments: JB SK GJDS RGW. Performed the experiments: JB SK AD DEW DK MF. Analyzed the data: JB AJD DK SK GJDS RGW MF IHM RJW. Contributed reagents/materials/analysis tools: GR SPP LJN YCFS VGD RAH TBS DEW AJD DW. Wrote the paper: JB SK MF IHM AJD DEW GJDS RGW. Programing for joint estimation of migration rates in BEAST: AJD DK. Programming for statistical comparison of tree congruence for assessing reassortment: MF.
The authors have declared that no competing interests exist.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1003570