Porous magnesium/PLGA composite scaffolds for enhanced bone regeneration following tooth extraction

[Display omitted] Sixty percent of implant-supported dental prostheses require bone grafting to enhance bone quantity and quality prior to implant placement. We have developed a metallic magnesium particle/PLGA composite scaffold to overcome the limitations of currently used dental bone grafting mat...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Acta biomaterialia Ročník 11; s. 543 - 553
Hlavní autoři:	Brown, Andrew, Zaky, Samer, Ray, Herbert, Sfeir, Charles
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Elsevier Ltd 01.01.2015
Témata:	Animals Bone regeneration Bone Regeneration - physiology Bones Degradation Dental implant Dental materials Devices Dogs Equipment Design Equipment Failure Analysis Female Guided Tissue Regeneration, Periodontal - instrumentation Guided Tissue Regeneration, Periodontal - methods Lactic Acid - chemistry Magnesium Magnesium - chemistry PLGA Polyglycolic Acid - chemistry Porosity Scaffolds Socket preservation Sockets Surgical implants Tissue Scaffolds Tooth Extraction - methods PLGA Magnesium Bone regeneration Dental implant Socket preservation
ISSN:	1742-7061, 1878-7568, 1878-7568
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	[Display omitted] Sixty percent of implant-supported dental prostheses require bone grafting to enhance bone quantity and quality prior to implant placement. We have developed a metallic magnesium particle/PLGA composite scaffold to overcome the limitations of currently used dental bone grafting materials. This is the first report of porous metallic magnesium/PLGA scaffolds synthesized using a solvent casting, salt leaching method. We found that incorporation of varying amounts of magnesium into the PLGA scaffolds increased the compressive strength and modulus, as well as provided a porous structure suitable for cell infiltration, as measured by mercury intrusion porosimetry. Additionally, combining basic-degrading magnesium with acidic-degrading PLGA led to an overall pH buffering effect and long-term release of magnesium over the course of a 10-week degradation assay, as measured with inductively coupled plasma–atomic emission spectroscopy. Using an indirect proliferation assay adapted from ISO 10993:5, it was found that extracts of medium from degrading magnesium/PLGA scaffolds increased bone marrow stromal cell proliferation in vitro, a phenomenon observed by other groups investigating magnesium’s impact on cells. Finally, magnesium/PLGA scaffold biocompatibility was assessed in a canine socket preservation model. Micro-computed tomography and histological analysis showed the magnesium/PLGA scaffolds to be safer and more effective at preserving bone height than empty controls. Three-dimensional magnesium/PLGA composite scaffolds show promise for dental socket preservation and also, potentially, orthopedic bone regeneration. These scaffolds could decrease inflammation observed with clinically used PLGA devices, as well as enhance osteogenesis, as observed with previously studied magnesium devices.
AbstractList	Sixty percent of implant-supported dental prostheses require bone grafting to enhance bone quantity and quality prior to implant placement. We have developed a metallic magnesium particle/PLGA composite scaffold to overcome the limitations of currently used dental bone grafting materials. This is the first report of porous metallic magnesium/PLGA scaffolds synthesized using a solvent casting, salt leaching method. We found that incorporation of varying amounts of magnesium into the PLGA scaffolds increased the compressive strength and modulus, as well as provided a porous structure suitable for cell infiltration, as measured by mercury intrusion porosimetry. Additionally, combining basic-degrading magnesium with acidic-degrading PLGA led to an overall pH buffering effect and long-term release of magnesium over the course of a 10-week degradation assay, as measured with inductively coupled plasma-atomic emission spectroscopy. Using an indirect proliferation assay adapted from ISO 10993:5, it was found that extracts of medium from degrading magnesium/PLGA scaffolds increased bone marrow stromal cell proliferation in vitro, a phenomenon observed by other groups investigating magnesium's impact on cells. Finally, magnesium/PLGA scaffold biocompatibility was assessed in a canine socket preservation model. Micro-computed tomography and histological analysis showed the magnesium/PLGA scaffolds to be safer and more effective at preserving bone height than empty controls. Three-dimensional magnesium/PLGA composite scaffolds show promise for dental socket preservation and also, potentially, orthopedic bone regeneration. These scaffolds could decrease inflammation observed with clinically used PLGA devices, as well as enhance osteogenesis, as observed with previously studied magnesium devices. Sixty percent of implant-supported dental prostheses require bone grafting to enhance bone quantity and quality prior to implant placement. We have developed a metallic magnesium particle/PLGA composite scaffold to overcome the limitations of currently used dental bone grafting materials. This is the first report of porous metallic magnesium/PLGA scaffolds synthesized using a solvent casting, salt leaching method. We found that incorporation of varying amounts of magnesium into the PLGA scaffolds increased the compressive strength and modulus, as well as provided a porous structure suitable for cell infiltration, as measured by mercury intrusion porosimetry. Additionally, combining basic-degrading magnesium with acidic-degrading PLGA led to an overall pH buffering effect and long-term release of magnesium over the course of a 10-week degradation assay, as measured with inductively coupled plasma-atomic emission spectroscopy. Using an indirect proliferation assay adapted from ISO 10993:5, it was found that extracts of medium from degrading magnesium/PLGA scaffolds increased bone marrow stromal cell proliferation in vitro, a phenomenon observed by other groups investigating magnesium's impact on cells. Finally, magnesium/PLGA scaffold biocompatibility was assessed in a canine socket preservation model. Micro-computed tomography and histological analysis showed the magnesium/PLGA scaffolds to be safer and more effective at preserving bone height than empty controls. Three-dimensional magnesium/PLGA composite scaffolds show promise for dental socket preservation and also, potentially, orthopedic bone regeneration. These scaffolds could decrease inflammation observed with clinically used PLGA devices, as well as enhance osteogenesis, as observed with previously studied magnesium devices.Sixty percent of implant-supported dental prostheses require bone grafting to enhance bone quantity and quality prior to implant placement. We have developed a metallic magnesium particle/PLGA composite scaffold to overcome the limitations of currently used dental bone grafting materials. This is the first report of porous metallic magnesium/PLGA scaffolds synthesized using a solvent casting, salt leaching method. We found that incorporation of varying amounts of magnesium into the PLGA scaffolds increased the compressive strength and modulus, as well as provided a porous structure suitable for cell infiltration, as measured by mercury intrusion porosimetry. Additionally, combining basic-degrading magnesium with acidic-degrading PLGA led to an overall pH buffering effect and long-term release of magnesium over the course of a 10-week degradation assay, as measured with inductively coupled plasma-atomic emission spectroscopy. Using an indirect proliferation assay adapted from ISO 10993:5, it was found that extracts of medium from degrading magnesium/PLGA scaffolds increased bone marrow stromal cell proliferation in vitro, a phenomenon observed by other groups investigating magnesium's impact on cells. Finally, magnesium/PLGA scaffold biocompatibility was assessed in a canine socket preservation model. Micro-computed tomography and histological analysis showed the magnesium/PLGA scaffolds to be safer and more effective at preserving bone height than empty controls. Three-dimensional magnesium/PLGA composite scaffolds show promise for dental socket preservation and also, potentially, orthopedic bone regeneration. These scaffolds could decrease inflammation observed with clinically used PLGA devices, as well as enhance osteogenesis, as observed with previously studied magnesium devices. [Display omitted] Sixty percent of implant-supported dental prostheses require bone grafting to enhance bone quantity and quality prior to implant placement. We have developed a metallic magnesium particle/PLGA composite scaffold to overcome the limitations of currently used dental bone grafting materials. This is the first report of porous metallic magnesium/PLGA scaffolds synthesized using a solvent casting, salt leaching method. We found that incorporation of varying amounts of magnesium into the PLGA scaffolds increased the compressive strength and modulus, as well as provided a porous structure suitable for cell infiltration, as measured by mercury intrusion porosimetry. Additionally, combining basic-degrading magnesium with acidic-degrading PLGA led to an overall pH buffering effect and long-term release of magnesium over the course of a 10-week degradation assay, as measured with inductively coupled plasma–atomic emission spectroscopy. Using an indirect proliferation assay adapted from ISO 10993:5, it was found that extracts of medium from degrading magnesium/PLGA scaffolds increased bone marrow stromal cell proliferation in vitro, a phenomenon observed by other groups investigating magnesium’s impact on cells. Finally, magnesium/PLGA scaffold biocompatibility was assessed in a canine socket preservation model. Micro-computed tomography and histological analysis showed the magnesium/PLGA scaffolds to be safer and more effective at preserving bone height than empty controls. Three-dimensional magnesium/PLGA composite scaffolds show promise for dental socket preservation and also, potentially, orthopedic bone regeneration. These scaffolds could decrease inflammation observed with clinically used PLGA devices, as well as enhance osteogenesis, as observed with previously studied magnesium devices.
Author	Ray, Herbert Brown, Andrew Zaky, Samer Sfeir, Charles
Author_xml	– sequence: 1 givenname: Andrew orcidid: 0000-0002-8669-3439 surname: Brown fullname: Brown, Andrew organization: Department of Oral Biology, 598 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA – sequence: 2 givenname: Samer surname: Zaky fullname: Zaky, Samer organization: Department of Oral Biology, 598 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA – sequence: 3 givenname: Herbert surname: Ray fullname: Ray, Herbert organization: The Center for Craniofacial Regeneration, 598 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA – sequence: 4 givenname: Charles surname: Sfeir fullname: Sfeir, Charles email: csfeir@pitt.edu organization: Department of Oral Biology, 598 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/25234156$$D View this record in MEDLINE/PubMed
BookMark	eNqNkUtvFDEQhC2UiDzgHyDkI5eZtD0P2xyQoggC0krJAc6Wx9Oz8WrGXmxvgH-Pl00uHJKcbKm_KnVXnZEjHzwS8o5BzYD1F5va2Dy4UHNgbQ2qBpCvyCmTQlai6-VR-YuWVwJ6dkLOUtoANJJx-Zqc8I43Lev6U2JvQwy7RBez9pjcbrm4XV1fUhuWbUguI03WTFOYx0SnECn6O-MtjnQoy9CIa_QYTXbBl_E8h1_Or2kOId9R_J1j2bCM3pDjycwJ3z685-THl8_fr75Wq5vrb1eXq8q2SuZqHI0UPXJojBLIhtZwhQ0gZwMHKaEDPqph7BtgUjHAiUtsDMrJgpU4qeacfDj4bmP4ucOU9eKSxXk2HsuNmvV9yaiT5fjn0VYAdKqVL0C5UoJzJgr6_gHdDQuOehvdYuIf_Rh3AT4eABtDShEnbV3-F1_Jys2agd53qzf60K3ed6tB6bJ3Ebf_iR_9n5F9OsiwRH_vMOpkHe5LdBFt1mNwTxv8BYkMv_Q
CitedBy_id	crossref_primary_10_1002_jbm_b_34131 crossref_primary_10_1016_j_bioactmat_2021_12_032 crossref_primary_10_1007_s11431_020_1689_3 crossref_primary_10_1016_j_actbio_2019_05_026 crossref_primary_10_1088_1758_5090_ac73b8 crossref_primary_10_1016_j_addma_2019_05_031 crossref_primary_10_1016_j_actbio_2019_04_061 crossref_primary_10_3390_jcs8010006 crossref_primary_10_1016_j_coco_2024_102024 crossref_primary_10_3390_ijms19030826 crossref_primary_10_1007_s11837_021_04992_5 crossref_primary_10_1016_j_colsurfb_2018_10_081 crossref_primary_10_1016_j_biomaterials_2020_119962 crossref_primary_10_1039_D0BM00834F crossref_primary_10_1016_j_jmbbm_2019_06_022 crossref_primary_10_1371_journal_pone_0228247 crossref_primary_10_1016_j_polymertesting_2018_03_042 crossref_primary_10_1002_adhm_202304060 crossref_primary_10_1016_j_addr_2016_03_012 crossref_primary_10_1007_s10973_020_09759_9 crossref_primary_10_1016_j_actbio_2017_08_004 crossref_primary_10_1016_j_compositesb_2025_112363 crossref_primary_10_1002_adhm_202000211 crossref_primary_10_1016_j_ceramint_2024_05_327 crossref_primary_10_1016_j_biomaterials_2021_120950 crossref_primary_10_1007_s00339_016_0538_1 crossref_primary_10_1038_s41467_021_23005_2 crossref_primary_10_1002_jbm_a_35657 crossref_primary_10_1063_1_5045339 crossref_primary_10_1016_j_matchemphys_2024_129911 crossref_primary_10_1016_j_jallcom_2025_182336 crossref_primary_10_3390_ma17235680 crossref_primary_10_1016_j_actbio_2015_12_037 crossref_primary_10_3390_jfb14030159 crossref_primary_10_1016_j_heliyon_2023_e22552 crossref_primary_10_1016_j_jmbbm_2024_106421 crossref_primary_10_2147_IJN_S390500 crossref_primary_10_1007_s40005_019_00439_x crossref_primary_10_1016_j_eurpolymj_2019_07_036 crossref_primary_10_1007_s40089_020_00318_6 crossref_primary_10_1007_s42114_020_00177_x crossref_primary_10_1016_j_ijbiomac_2019_09_020 crossref_primary_10_1002_jbm_a_35625 crossref_primary_10_1016_j_matlet_2015_09_039 crossref_primary_10_1007_s10439_018_2058_y crossref_primary_10_1080_17568919_2025_2458457 crossref_primary_10_1016_j_jmbbm_2021_104768 crossref_primary_10_1016_j_jobcr_2016_03_001 crossref_primary_10_1016_j_jddst_2021_102558 crossref_primary_10_1002_jbm_a_37767 crossref_primary_10_1007_s10856_021_06561_3 crossref_primary_10_3390_met12122074 crossref_primary_10_1016_j_ijbiomac_2019_12_249 crossref_primary_10_1002_jbm_a_37660 crossref_primary_10_1007_s10904_025_03833_1 crossref_primary_10_1016_j_bioactmat_2021_10_019 crossref_primary_10_1016_j_matdes_2018_09_019 crossref_primary_10_3389_fbioe_2020_00564 crossref_primary_10_1016_j_bioactmat_2020_02_012 crossref_primary_10_1016_j_jconrel_2022_08_036 crossref_primary_10_3390_gels10020140 crossref_primary_10_1016_j_jmbbm_2018_08_002 crossref_primary_10_1177_15353702211052927 crossref_primary_10_1007_s10934_017_0450_x crossref_primary_10_1155_2016_1239842 crossref_primary_10_1002_jbm_a_36446 crossref_primary_10_1007_s10856_017_5908_5 crossref_primary_10_1016_j_actbio_2018_08_030 crossref_primary_10_1016_j_compositesb_2021_109270 crossref_primary_10_1016_j_actbio_2018_12_017 crossref_primary_10_1007_s40195_018_0841_2 crossref_primary_10_1080_09506608_2018_1460943 crossref_primary_10_1016_j_cej_2025_161315 crossref_primary_10_1002_mabi_201600057 crossref_primary_10_1016_j_actbio_2021_03_067 crossref_primary_10_1016_j_jtice_2024_105619 crossref_primary_10_1007_s10934_017_0467_1 crossref_primary_10_1016_j_jma_2018_02_003 crossref_primary_10_3390_molecules27175529 crossref_primary_10_1088_1748_605X_aadb47 crossref_primary_10_1016_j_polymdegradstab_2020_109427 crossref_primary_10_1016_j_proeng_2016_06_688 crossref_primary_10_1016_j_jconrel_2015_07_031 crossref_primary_10_1016_j_apsusc_2015_12_243 crossref_primary_10_3390_polym15081907 crossref_primary_10_3390_polym14122422 crossref_primary_10_1038_srep11194 crossref_primary_10_3389_fbioe_2022_859280 crossref_primary_10_3390_jfb13040267 crossref_primary_10_3390_ma15030827 crossref_primary_10_1016_j_jddst_2025_106806 crossref_primary_10_3390_polym13071061 crossref_primary_10_1002_adma_202005140 crossref_primary_10_1016_j_matdes_2023_112351 crossref_primary_10_1016_j_bioactmat_2021_01_011 crossref_primary_10_1080_09205063_2025_2515953 crossref_primary_10_1007_s10965_023_03542_8 crossref_primary_10_3390_polym14245460 crossref_primary_10_1002_jbm_b_35246 crossref_primary_10_1016_j_eurpolymj_2018_10_012 crossref_primary_10_1155_2017_4585401 crossref_primary_10_3390_nano11051129 crossref_primary_10_1108_RPJ_06_2021_0152 crossref_primary_10_3389_fbioe_2021_718718 crossref_primary_10_1016_j_matpr_2017_01_101 crossref_primary_10_1088_1748_605X_aaaa29 crossref_primary_10_1016_j_optlastec_2025_112549 crossref_primary_10_1039_C9BM00664H crossref_primary_10_1097_SCS_0000000000009750 crossref_primary_10_1186_s12938_020_0755_x crossref_primary_10_1016_j_addma_2020_101142 crossref_primary_10_3390_ma15165669 crossref_primary_10_1007_s11665_024_10242_x crossref_primary_10_1016_j_biomaterials_2015_10_042 crossref_primary_10_1038_srep34029 crossref_primary_10_1016_j_mtla_2020_100661 crossref_primary_10_1016_j_biomaterials_2016_01_046 crossref_primary_10_1016_j_jallcom_2022_166377 crossref_primary_10_1016_j_compositesb_2021_109461 crossref_primary_10_1016_j_matdes_2016_06_080 crossref_primary_10_1177_08853282251324799 crossref_primary_10_3390_jfb15080233 crossref_primary_10_1007_s41745_019_00124_w crossref_primary_10_5812_jcrps_124080 crossref_primary_10_1002_jbm_a_35959 crossref_primary_10_3233_BME_161568 crossref_primary_10_1016_j_biomaterials_2024_122975 crossref_primary_10_3390_app14041512 crossref_primary_10_3390_ma12162581 crossref_primary_10_1002_agt2_176
Cites_doi	10.1902/jop.2008.070502 10.1016/j.actbio.2009.07.016 10.1016/j.biomaterials.2006.01.039 10.1007/BF02628418 10.1016/j.matlet.2012.01.134 10.1111/j.1600-0501.2010.02064.x 10.1111/j.1600-0501.2009.01821.x 10.1007/s10856-009-3727-z 10.1902/jop.2007.060048 10.1902/jop.2003.74.7.965 10.1902/jop.2003.74.7.990 10.1016/j.biomaterials.2005.10.003 10.1902/jop.1996.67.10.1025 10.1007/s10856-011-4354-z 10.1111/j.1600-051X.2005.00642.x 10.1111/j.1600-0501.2010.01937.x 10.1089/ten.2006.12.3545 10.1023/A:1007513425337 10.1016/j.biomaterials.2004.09.049 10.1007/s00264-007-0418-6 10.1073/pnas.97.7.3213 10.1016/0022-3913(67)90046-7 10.1111/j.1600-051X.2010.01691.x 10.1097/01.scs.0000179662.38172.dd 10.1111/clr.12132 10.1111/j.1600-0501.2008.01575.x 10.1111/j.1600-051X.2005.00729.x 10.1097/00003086-200202000-00009 10.1016/j.biomaterials.2009.11.111 10.1902/jop.1998.69.9.1044 10.1111/j.1600-0501.2007.01311.x 10.1111/j.1600-0501.2010.01918.x 10.1016/j.actbio.2014.02.002 10.1111/j.1600-0501.2010.01922.x 10.1016/j.mseb.2011.04.008 10.1016/0032-3861(94)90953-9 10.1634/stemcells.20-6-530 10.1016/0142-9612(96)85754-1 10.3390/polym3031377 10.1111/j.1600-0501.2010.02068.x 10.22203/eCM.v011a06 10.1055/s-0039-1697860 10.1007/s10856-012-4773-5 10.1038/71916 10.1016/j.polymer.2005.02.120
ContentType	Journal Article
Copyright	2014 Copyright © 2014. Published by Elsevier Ltd.
Copyright_xml	– notice: 2014 – notice: Copyright © 2014. Published by Elsevier Ltd.
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 7QO 8FD FR3 P64 7QF 7SR 7TB 7U5 8BQ F28 JG9 L7M
DOI	10.1016/j.actbio.2014.09.008
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic Biotechnology Research Abstracts Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts Aluminium Industry Abstracts Engineered Materials Abstracts Mechanical & Transportation Engineering Abstracts Solid State and Superconductivity Abstracts METADEX ANTE: Abstracts in New Technology & Engineering Materials Research Database Advanced Technologies Database with Aerospace
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic Engineering Research Database Biotechnology Research Abstracts Technology Research Database Biotechnology and BioEngineering Abstracts Materials Research Database Engineered Materials Abstracts Aluminium Industry Abstracts Mechanical & Transportation Engineering Abstracts Solid State and Superconductivity Abstracts Advanced Technologies Database with Aerospace ANTE: Abstracts in New Technology & Engineering METADEX
DatabaseTitleList	Engineering Research Database MEDLINE - Academic MEDLINE Materials Research Database
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Engineering
EISSN	1878-7568
EndPage	553
ExternalDocumentID	25234156 10_1016_j_actbio_2014_09_008 S1742706114003912
Genre	Research Support, U.S. Gov't, Non-P.H.S Journal Article
GroupedDBID	--- --K --M .~1 0R~ 1B1 1~. 1~5 23M 4.4 457 4G. 53G 5GY 5VS 7-5 71M 8P~ AABXZ AACTN AAEDT AAEDW AAEPC AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAXUO ABGSF ABJNI ABMAC ABNUV ABUDA ABXRA ABYKQ ACDAQ ACGFS ACIWK ACPRK ACRLP ADBBV ADEWK ADEZE ADUVX AEBSH AEHWI AEKER AENEX AEZYN AFKWA AFRAH AFRZQ AFTJW AFXIZ AGHFR AGUBO AGYEJ AHPOS AIEXJ AIKHN AITUG AJBFU AJOXV AKURH ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLXMC CS3 DOVZS EBS EFJIC EFLBG EJD ENUVR EO8 EO9 EP2 EP3 F5P FDB FEDTE FIRID FNPLU FYGXN G-Q GBLVA HVGLF HZ~ IHE J1W KOM M41 MAGPM MO0 N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 RIG RNS ROL RPZ SDF SDG SES SPC SPCBC SSG SSM SSU SSZ T5K ~G- 9DU AATTM AAXKI AAYWO AAYXX ABFNM ABWVN ABXDB ACLOT ACNNM ACRPL ACVFH ADCNI ADMUD ADNMO AEIPS AEUPX AFJKZ AFPUW AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP CITATION EFKBS SEW ~HD AGCQF AGRNS BNPGV CGR CUY CVF ECM EIF NPM SSH 7X8 7QO 8FD FR3 P64 7QF 7SR 7TB 7U5 8BQ F28 JG9 L7M
ID	FETCH-LOGICAL-c498t-dda876e203a97e1b4a29e30e21b20880502d9bd63018910ef28e3ae8fc0c8ef93
ISICitedReferencesCount	182
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000347747900052&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1742-7061 1878-7568
IngestDate	Sun Sep 28 06:49:40 EDT 2025 Tue Oct 07 09:23:52 EDT 2025 Thu Sep 25 08:32:42 EDT 2025 Mon Jul 21 06:04:41 EDT 2025 Sat Nov 29 02:34:42 EST 2025 Tue Nov 18 21:03:47 EST 2025 Fri Feb 23 02:35:05 EST 2024
IsPeerReviewed	true
IsScholarly	true
Keywords	PLGA Magnesium Bone regeneration Dental implant Socket preservation
Language	English
License	Copyright © 2014. Published by Elsevier Ltd.
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c498t-dda876e203a97e1b4a29e30e21b20880502d9bd63018910ef28e3ae8fc0c8ef93
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ORCID	0000-0002-8669-3439
PMID	25234156
PQID	1629972217
PQPubID	23479
PageCount	11
ParticipantIDs	proquest_miscellaneous_1660085852 proquest_miscellaneous_1647005948 proquest_miscellaneous_1629972217 pubmed_primary_25234156 crossref_citationtrail_10_1016_j_actbio_2014_09_008 crossref_primary_10_1016_j_actbio_2014_09_008 elsevier_sciencedirect_doi_10_1016_j_actbio_2014_09_008
PublicationCentury	2000
PublicationDate	2015-01-01
PublicationDateYYYYMMDD	2015-01-01
PublicationDate_xml	– month: 01 year: 2015 text: 2015-01-01 day: 01
PublicationDecade	2010
PublicationPlace	England
PublicationPlace_xml	– name: England
PublicationTitle	Acta biomaterialia
PublicationTitleAlternate	Acta Biomater
PublicationYear	2015
Publisher	Elsevier Ltd
Publisher_xml	– name: Elsevier Ltd
References	Rezwan, QZ, JJ, AR (b0195) 2006; 27 Zubillaga, Von Hagen, Simon, Deasy (b0095) 2003; 74 LeGeros (b0110) 2002; 395 Witte, Hort, Vogt, Cohen, Kainer, Willumeit (b0170) 2009 Battistella, Varoni, Cochis, Palazzo, Rimondini (b0140) 2011; 9 Ten Heggeler, Slot, Van der Weijden (b0035) 2011; 22 Pietrokovski, Massler (b0025) 1967; 17 Knedler, Ham (b0255) 1987; 23 Mikos, Thorsen, Czerwonka, Bao, Langer, Winslow (b0230) 1994; 35 Wong, Yeung, Lam, Tam, Chu, Luk (b0220) 2010; 31 Araujo, Lindhe (b0085) 2011; 22 Athanasiou, Niederauer, Agarwal (b0150) 1996; 17 Shen, Hu, Yang, Bei, Wang (b0155) 2010; 6 Staiger, Pietak, Huadmai, Dias (b0165) 2006 Serino, Rao, Iezzi, Piattelli (b0120) 2008; 19 Shaw (b0240) 2003 Wallace, Froum, Cho, Elian, Monteiro, Kim (b0045) 2005; 25 Hoffmann, Bartee, Beaumont, Kasaj, Deli, Zafiropoulos (b0070) 2008; 79 Kim, Choi, Cho, Chai, Wikesjo, Kim (b0010) 2005; 32 Lekovic, Camargo, Klokkevold, Weinlaender, Kenney, Dimitrijevic (b0075) 1998; 69 Fickl, Zuhr, Wachtel, Bolz, Huerzeler (b0040) 2008; 19 Jung, Kokovic, Jurisic, Yaman, Subramani, Weber (b0135) 2011; 22 Mardas, Chadha, Donos (b0065) 2010; 21 Fischer, Profrock, Hort, Willumeit, Feyerabend (b0235) 2011; 176 Schneider, Weber, Grunder, Andreoni, Burkhardt, Jung (b0130) 2014; 25 Retzepi, Donos (b0080) 2009; 21 Colter, Class, DiGirolamo, Prockop (b0015) 2000; 97 Keles, Sumer, Cetinkaya, Tutkum, Simsek (b0005) 2010; 4 Eppley, Pietrzak, Blanton (b0105) 2005; 16 McKay, Peckham, Badura (b0160) 2007; 31 Lim, Poh, Wang (b0250) 2009; 20 Min, Wikesjo, Park, Chae, Pippig, Bastone (b0125) 2011; 38 Frenken, Bouwman, Bravenboer, Zijderveld, Schulten, Ten Bruggenkate (b0115) 2010; 21 Zhang, Wu, Jing, Ding (b0245) 2005; 46 Feyerabend, Witte, Kammal, Willumeit (b0185) 2006; 12 Yoshizawa, Brown, Barchowsky, Sfeir (b0180) 2014 Araujo, Lindhe (b0030) 2005; 32 McAllister, Haghighat (b0060) 2007; 78 Lasella, Greenwell, Miller, Hill, Drisko, Bohra (b0100) 2003; 74 Ostrowski, Lee, Roy, Ramanathan, Kumta (b0210) 2013; 24 Buser, Dula, Hirt, Schenk (b0050) 1996; 10 Guo, Cao, Lu, Liu, Xu (b0215) 2011; 22 Sekiya, Larson, Smith, OPochampally, Cui, Prockop (b0020) 2002; 20 Proussaefs, Lozada (b0055) 2005; 25 Zhu, Mallery, Schwendeman (b0200) 2000; 18 Wahl, Czernuszka (b0190) 2006; 11 Cifuentes, Frutos, Gonzalez-Carrasco, Munoz, Multigner, Chao (b0225) 2012; 74 Becker, Urist, Becker, Jackson, Parry, Bartold (b0090) 1996; 67 Zhu, Schwendeman (b0205) 2000; 17 Witte, Kaese, Haferkamp, Switzer, Meyer-Lindenberg, Wirth (b0175) 2005; 26 Makadia, Siegel (b0145) 2011; 3 Makadia (10.1016/j.actbio.2014.09.008_b0145) 2011; 3 Lekovic (10.1016/j.actbio.2014.09.008_b0075) 1998; 69 Araujo (10.1016/j.actbio.2014.09.008_b0030) 2005; 32 Knedler (10.1016/j.actbio.2014.09.008_b0255) 1987; 23 Zhang (10.1016/j.actbio.2014.09.008_b0245) 2005; 46 Wong (10.1016/j.actbio.2014.09.008_b0220) 2010; 31 Staiger (10.1016/j.actbio.2014.09.008_b0165) 2006 Sekiya (10.1016/j.actbio.2014.09.008_b0020) 2002; 20 LeGeros (10.1016/j.actbio.2014.09.008_b0110) 2002; 395 Cifuentes (10.1016/j.actbio.2014.09.008_b0225) 2012; 74 McKay (10.1016/j.actbio.2014.09.008_b0160) 2007; 31 Hoffmann (10.1016/j.actbio.2014.09.008_b0070) 2008; 79 Becker (10.1016/j.actbio.2014.09.008_b0090) 1996; 67 Frenken (10.1016/j.actbio.2014.09.008_b0115) 2010; 21 Shaw (10.1016/j.actbio.2014.09.008_b0240) 2003 Witte (10.1016/j.actbio.2014.09.008_b0170) 2009 Fickl (10.1016/j.actbio.2014.09.008_b0040) 2008; 19 Witte (10.1016/j.actbio.2014.09.008_b0175) 2005; 26 Proussaefs (10.1016/j.actbio.2014.09.008_b0055) 2005; 25 Schneider (10.1016/j.actbio.2014.09.008_b0130) 2014; 25 Yoshizawa (10.1016/j.actbio.2014.09.008_b0180) 2014 Retzepi (10.1016/j.actbio.2014.09.008_b0080) 2009; 21 Jung (10.1016/j.actbio.2014.09.008_b0135) 2011; 22 Fischer (10.1016/j.actbio.2014.09.008_b0235) 2011; 176 Shen (10.1016/j.actbio.2014.09.008_b0155) 2010; 6 Feyerabend (10.1016/j.actbio.2014.09.008_b0185) 2006; 12 Araujo (10.1016/j.actbio.2014.09.008_b0085) 2011; 22 Wahl (10.1016/j.actbio.2014.09.008_b0190) 2006; 11 Rezwan (10.1016/j.actbio.2014.09.008_b0195) 2006; 27 Min (10.1016/j.actbio.2014.09.008_b0125) 2011; 38 Serino (10.1016/j.actbio.2014.09.008_b0120) 2008; 19 Lim (10.1016/j.actbio.2014.09.008_b0250) 2009; 20 Ten Heggeler (10.1016/j.actbio.2014.09.008_b0035) 2011; 22 Zhu (10.1016/j.actbio.2014.09.008_b0200) 2000; 18 Wallace (10.1016/j.actbio.2014.09.008_b0045) 2005; 25 Eppley (10.1016/j.actbio.2014.09.008_b0105) 2005; 16 Pietrokovski (10.1016/j.actbio.2014.09.008_b0025) 1967; 17 Keles (10.1016/j.actbio.2014.09.008_b0005) 2010; 4 Kim (10.1016/j.actbio.2014.09.008_b0010) 2005; 32 Zhu (10.1016/j.actbio.2014.09.008_b0205) 2000; 17 Guo (10.1016/j.actbio.2014.09.008_b0215) 2011; 22 Mardas (10.1016/j.actbio.2014.09.008_b0065) 2010; 21 Mikos (10.1016/j.actbio.2014.09.008_b0230) 1994; 35 McAllister (10.1016/j.actbio.2014.09.008_b0060) 2007; 78 Battistella (10.1016/j.actbio.2014.09.008_b0140) 2011; 9 Lasella (10.1016/j.actbio.2014.09.008_b0100) 2003; 74 Buser (10.1016/j.actbio.2014.09.008_b0050) 1996; 10 Ostrowski (10.1016/j.actbio.2014.09.008_b0210) 2013; 24 Athanasiou (10.1016/j.actbio.2014.09.008_b0150) 1996; 17 Colter (10.1016/j.actbio.2014.09.008_b0015) 2000; 97 Zubillaga (10.1016/j.actbio.2014.09.008_b0095) 2003; 74
References_xml	– volume: 22 start-page: 9 year: 2011 end-page: 13 ident: b0085 article-title: Socket grafting with the use of autologous bone: an experimental study in the dog publication-title: Clin Oral Implant Res – volume: 17 start-page: 21 year: 1967 end-page: 27 ident: b0025 article-title: Alveolar ridge resorption following tooth extraction publication-title: J Prosthet Dent – volume: 25 start-page: 551 year: 2005 end-page: 559 ident: b0045 article-title: Sinus augmentation utilizing anorganic bovine bone (Bio-Oss) with absorbable and nonabsorbable membranes placed over the lateral window: histomorphometric and clinical analyses publication-title: Int J Periodontics Restorative Dent – volume: 19 start-page: 16 year: 2008 end-page: 31 ident: b0120 article-title: Polylactide and polyglycolide sponge used in human extraction sockets: bone formation following 3 months after its application publication-title: Clin Oral Implant Res – volume: 31 start-page: 729 year: 2007 end-page: 734 ident: b0160 article-title: A comprehensive clinical review of recombinant human bone morphogenetic protein-2 (INFUSE Bone Graft) publication-title: Int Orthop – volume: 97 start-page: 3213 year: 2000 end-page: 3218 ident: b0015 article-title: Rapid expansion of recycling stem cells in culture of plastic adherent cells from human bone marrow publication-title: Proc Natl Acad Sci USA – volume: 25 start-page: 351 year: 2005 end-page: 363 ident: b0055 article-title: The use of intraorally harvested autogenous block grafts for vertical alveolar ridge augmentation: a human study publication-title: Int J Periodontics Restorative Dent – volume: 18 start-page: 52 year: 2000 end-page: 57 ident: b0200 article-title: Stabilization of proteins encapsulated in injectable poly (lactide-co-glycolide) publication-title: Nat Biotechnol – volume: 19 start-page: 1111 year: 2008 end-page: 1118 ident: b0040 article-title: Hard tissue alterations after socket preservation: an experimental study in the beagle dog publication-title: Clin Oral Implant Res – volume: 22 start-page: 802 year: 2011 end-page: 807 ident: b0135 article-title: Guided bone regeneration with a synthetic biodegradable membrane: a comparative study in dogs publication-title: Clin Oral Implant Res – volume: 4 start-page: 403 year: 2010 end-page: 411 ident: b0005 article-title: Effect of autogenous cortical bone grafting in conjunction with guided tissue regeneration in the treatment of intraosseous periodontal defects publication-title: Eur J Dent – volume: 20 start-page: 1669 year: 2009 end-page: 1675 ident: b0250 article-title: Poly (lactic-co-glycolic acid) as a controlled release delivery device publication-title: J Mater Sci - Mater Med – volume: 17 start-page: 351 year: 2000 end-page: 357 ident: b0205 article-title: Stabilization of proteins encapsulated in cylindrical poly(lactide-co-glycolide) implants: mechanism of stabilization by basic additives publication-title: Pharm Res – volume: 46 start-page: 4979 year: 2005 end-page: 4985 ident: b0245 article-title: A comparative study of porous scaffolds with cubic and spherical macropores publication-title: Polymer – volume: 6 start-page: 455 year: 2010 end-page: 465 ident: b0155 article-title: An injectable scaffold: rhBMP-2-loaded poly(lactide-co-glycolide)/hydroxyapatite composite microspheres publication-title: Acta Biomater – volume: 395 start-page: 81 year: 2002 end-page: 98 ident: b0110 article-title: Properties of osteoconductive biomaterials: calcium phosphates publication-title: Clin Orthop Relat Res – volume: 3 start-page: 1377 year: 2011 end-page: 1397 ident: b0145 article-title: Poly Lactic-co-Glycolic Acid (PLGA) as a biodegradable controlled drug delivery carrier publication-title: Polymers – volume: 17 start-page: 92 year: 1996 end-page: 102 ident: b0150 article-title: Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/polyglycolic acid copolymers publication-title: Biomaterials – year: 2014 ident: b0180 article-title: Magnesium ion stimulation of bone marrow stromal cells enhances osteogenic activity, simulating the effect of magnesium alloy degradation publication-title: Acta Biomater – volume: 22 start-page: 1735 year: 2011 end-page: 1740 ident: b0215 article-title: Anticorrosion and cytocompatibility behavior of MAO/PLLA modified magnesium alloy WE42 publication-title: J Mater Sci - Mater Med – volume: 24 start-page: 85 year: 2013 end-page: 96 ident: b0210 article-title: Biodegradable poly(lactide-co-glycolide) coatings on magnesium alloys for orthopedic applications publication-title: J Mater Sci - Mater Med – volume: 20 start-page: 530 year: 2002 end-page: 541 ident: b0020 article-title: Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality publication-title: Stem Cells – volume: 74 start-page: 239 year: 2012 end-page: 242 ident: b0225 article-title: Novel PLLA/magnesium composite for orthopedic applications: a proof of concept publication-title: Mater Lett – volume: 38 start-page: 261 year: 2011 end-page: 268 ident: b0125 article-title: Wound healing/regeneration using recombinant human growth/differentiation factor-5 in an injectable poly-lactide-co-glycolide-acid composite carrier and a one-wall intra-bony defect model in dogs publication-title: J Clin Periodontol – volume: 31 start-page: 2084 year: 2010 end-page: 2096 ident: b0220 article-title: A biodegradable polymer-based coating to control the performance of magnesium alloy orthopaedic implants publication-title: Biomaterials – year: 2003 ident: b0240 publication-title: Corrosion resistance of magnesium alloys – volume: 25 start-page: 150 year: 2014 end-page: 158 ident: b0130 article-title: A randomized controlled clinical multicenter trial comparing the clinical and histological performance of a new, modified polylactide-co-glycolide acid membrane to an expanded polytetrafluorethylene membrane in guided bone regeneration procedures publication-title: Clin Oral Implant Res – volume: 11 start-page: 43 year: 2006 end-page: 56 ident: b0190 article-title: Collagen-hydroxyapatite composites for hard tissue repair publication-title: Eur Cells Mater – start-page: 1728 year: 2006 end-page: 1734 ident: b0165 article-title: Magnesium and its alloys as orthopedic biomaterials: a review publication-title: Biomaterials – volume: 67 start-page: 1025 year: 1996 end-page: 1033 ident: b0090 article-title: Clinical and histological observations of sites implanted with intraoral autologous bone grafts or allografts. 15 human case reports publication-title: J Periodontol – volume: 35 start-page: 1068 year: 1994 end-page: 1077 ident: b0230 article-title: Preparation and characterization of poly(l-lactic acid) foams publication-title: Polymer – volume: 176 start-page: 830 year: 2011 end-page: 834 ident: b0235 article-title: Improved cytotoxicity testing of magnesium materials publication-title: Mater Sci Eng, B – volume: 26 start-page: 3557 year: 2005 end-page: 3563 ident: b0175 article-title: In vivo corrosion of four magnesium alloys and the associated bone response publication-title: Biomaterials – volume: 78 start-page: 377 year: 2007 end-page: 396 ident: b0060 article-title: Bone augmentation techniques publication-title: J Periodontol – volume: 21 start-page: 567 year: 2009 end-page: 576 ident: b0080 article-title: Guided bone regeneration: biological principle and therapeutic applications publication-title: Clin Oral Implant Res – volume: 21 start-page: 688 year: 2010 end-page: 698 ident: b0065 article-title: Alveolar ridge preservation with guided bone regeneration and a synthetic bone substitute or a bovine-derived xenograft: a randomized, controlled clinical trial publication-title: Clin Oral Implant Res – volume: 69 start-page: 1044 year: 1998 end-page: 1049 ident: b0075 article-title: Preservation of alveolar bone in extraction sockets using bioabsorbable membranes publication-title: J Periodontol – volume: 32 start-page: 212 year: 2005 end-page: 218 ident: b0030 article-title: Dimensional ridge alterations following tooth extraction. An experimental study in the dog publication-title: J Clin Periodontol – volume: 74 start-page: 965 year: 2003 end-page: 975 ident: b0095 article-title: Changes in alveolar bone height and width following post-extraction ridge augmentation using a fixed bioabsorbable membrane and demineralized freeze-dried bone osteoinductive graft publication-title: J Periodontol – volume: 10 start-page: 312 year: 1996 end-page: 318 ident: b0050 article-title: Lateral ridge augmentation using autografts and barrier membranes: a clinical study with 40 partially edentulous patients publication-title: J Oral Maxillofac Surg – volume: 9 start-page: 223 year: 2011 end-page: 231 ident: b0140 article-title: Degradable polymers may improve dental practice publication-title: J Appl Biomater Biomech – volume: 22 start-page: 779 year: 2011 end-page: 788 ident: b0035 article-title: Effect of socket preservation therapies following tooth extraction in non-molar regions in humans: a systematic review publication-title: Clin Oral Implant Res – volume: 27 start-page: 3413 year: 2006 end-page: 3431 ident: b0195 article-title: Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering publication-title: Biomaterials – volume: 74 start-page: 990 year: 2003 end-page: 999 ident: b0100 article-title: Ridge preservation with freeze-dried bone allograft and a collagen membrane compared to extraction alone for implant site development: a clinical and histologic study in humans publication-title: J Periodontol – volume: 12 start-page: 3545 year: 2006 end-page: 3556 ident: b0185 article-title: Unphysiologically High Magnesium Concentrations Support Chondrocyte Proliferation and Redifferentiation publication-title: Tissue Eng – volume: 23 start-page: 481 year: 1987 end-page: 491 ident: b0255 article-title: Optimized medium for clonal growth of human microvascular endothelial cells with minimal serum publication-title: Vitro Cell Dev Biol – volume: 79 start-page: 1355 year: 2008 end-page: 1369 ident: b0070 article-title: Alveolar bone preservation in extraction sockets using non-resorbable dPTFE membranes: a retrospective non-randomized study publication-title: J Periodontol – volume: 16 start-page: 981 year: 2005 end-page: 989 ident: b0105 article-title: Allograft and alloplastic bone substitutes: a review of science and technology for the craniomaxillofacial surgeon publication-title: J Craniofac Surg – year: 2009 ident: b0170 article-title: Degradable biomaterials based on magnesium corrosion publication-title: Curr Opin Solid State Mater Sci – volume: 21 start-page: 201 year: 2010 end-page: 208 ident: b0115 article-title: The use of Straumann Bone Cermaic in a maxillary sinus floor elevation procedure: a clinical, radiological, histological and histomorphometric evaluation with a 6-month healing period publication-title: Clin Oral Implant Res – volume: 32 start-page: 583 year: 2005 end-page: 589 ident: b0010 article-title: Periodontal healing in one-wall intra-bony defects in dogs following implantation of autogenous bone or a coral-derived biomaterial publication-title: J Clin Periodontol – volume: 79 start-page: 1355 issue: 8 year: 2008 ident: 10.1016/j.actbio.2014.09.008_b0070 article-title: Alveolar bone preservation in extraction sockets using non-resorbable dPTFE membranes: a retrospective non-randomized study publication-title: J Periodontol doi: 10.1902/jop.2008.070502 – volume: 6 start-page: 455 issue: 2 year: 2010 ident: 10.1016/j.actbio.2014.09.008_b0155 article-title: An injectable scaffold: rhBMP-2-loaded poly(lactide-co-glycolide)/hydroxyapatite composite microspheres publication-title: Acta Biomater doi: 10.1016/j.actbio.2009.07.016 – volume: 27 start-page: 3413 issue: 18 year: 2006 ident: 10.1016/j.actbio.2014.09.008_b0195 article-title: Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering publication-title: Biomaterials doi: 10.1016/j.biomaterials.2006.01.039 – volume: 23 start-page: 481 issue: 7 year: 1987 ident: 10.1016/j.actbio.2014.09.008_b0255 article-title: Optimized medium for clonal growth of human microvascular endothelial cells with minimal serum publication-title: Vitro Cell Dev Biol doi: 10.1007/BF02628418 – volume: 74 start-page: 239 issue: 1 year: 2012 ident: 10.1016/j.actbio.2014.09.008_b0225 article-title: Novel PLLA/magnesium composite for orthopedic applications: a proof of concept publication-title: Mater Lett doi: 10.1016/j.matlet.2012.01.134 – volume: 22 start-page: 779 year: 2011 ident: 10.1016/j.actbio.2014.09.008_b0035 article-title: Effect of socket preservation therapies following tooth extraction in non-molar regions in humans: a systematic review publication-title: Clin Oral Implant Res doi: 10.1111/j.1600-0501.2010.02064.x – volume: 25 start-page: 551 issue: 6 year: 2005 ident: 10.1016/j.actbio.2014.09.008_b0045 article-title: Sinus augmentation utilizing anorganic bovine bone (Bio-Oss) with absorbable and nonabsorbable membranes placed over the lateral window: histomorphometric and clinical analyses publication-title: Int J Periodontics Restorative Dent – volume: 21 start-page: 201 issue: 2 year: 2010 ident: 10.1016/j.actbio.2014.09.008_b0115 article-title: The use of Straumann Bone Cermaic in a maxillary sinus floor elevation procedure: a clinical, radiological, histological and histomorphometric evaluation with a 6-month healing period publication-title: Clin Oral Implant Res doi: 10.1111/j.1600-0501.2009.01821.x – volume: 20 start-page: 1669 issue: 8 year: 2009 ident: 10.1016/j.actbio.2014.09.008_b0250 article-title: Poly (lactic-co-glycolic acid) as a controlled release delivery device publication-title: J Mater Sci - Mater Med doi: 10.1007/s10856-009-3727-z – volume: 78 start-page: 377 issue: 3 year: 2007 ident: 10.1016/j.actbio.2014.09.008_b0060 article-title: Bone augmentation techniques publication-title: J Periodontol doi: 10.1902/jop.2007.060048 – volume: 74 start-page: 965 year: 2003 ident: 10.1016/j.actbio.2014.09.008_b0095 article-title: Changes in alveolar bone height and width following post-extraction ridge augmentation using a fixed bioabsorbable membrane and demineralized freeze-dried bone osteoinductive graft publication-title: J Periodontol doi: 10.1902/jop.2003.74.7.965 – volume: 74 start-page: 990 issue: 7 year: 2003 ident: 10.1016/j.actbio.2014.09.008_b0100 article-title: Ridge preservation with freeze-dried bone allograft and a collagen membrane compared to extraction alone for implant site development: a clinical and histologic study in humans publication-title: J Periodontol doi: 10.1902/jop.2003.74.7.990 – start-page: 1728 year: 2006 ident: 10.1016/j.actbio.2014.09.008_b0165 article-title: Magnesium and its alloys as orthopedic biomaterials: a review publication-title: Biomaterials doi: 10.1016/j.biomaterials.2005.10.003 – volume: 67 start-page: 1025 issue: 10 year: 1996 ident: 10.1016/j.actbio.2014.09.008_b0090 article-title: Clinical and histological observations of sites implanted with intraoral autologous bone grafts or allografts. 15 human case reports publication-title: J Periodontol doi: 10.1902/jop.1996.67.10.1025 – year: 2009 ident: 10.1016/j.actbio.2014.09.008_b0170 article-title: Degradable biomaterials based on magnesium corrosion publication-title: Curr Opin Solid State Mater Sci – volume: 22 start-page: 1735 issue: 7 year: 2011 ident: 10.1016/j.actbio.2014.09.008_b0215 article-title: Anticorrosion and cytocompatibility behavior of MAO/PLLA modified magnesium alloy WE42 publication-title: J Mater Sci - Mater Med doi: 10.1007/s10856-011-4354-z – volume: 32 start-page: 212 issue: 2 year: 2005 ident: 10.1016/j.actbio.2014.09.008_b0030 article-title: Dimensional ridge alterations following tooth extraction. An experimental study in the dog publication-title: J Clin Periodontol doi: 10.1111/j.1600-051X.2005.00642.x – volume: 22 start-page: 9 issue: 1 year: 2011 ident: 10.1016/j.actbio.2014.09.008_b0085 article-title: Socket grafting with the use of autologous bone: an experimental study in the dog publication-title: Clin Oral Implant Res doi: 10.1111/j.1600-0501.2010.01937.x – volume: 12 start-page: 3545 issue: 12 year: 2006 ident: 10.1016/j.actbio.2014.09.008_b0185 article-title: Unphysiologically High Magnesium Concentrations Support Chondrocyte Proliferation and Redifferentiation publication-title: Tissue Eng doi: 10.1089/ten.2006.12.3545 – volume: 17 start-page: 351 issue: 3 year: 2000 ident: 10.1016/j.actbio.2014.09.008_b0205 article-title: Stabilization of proteins encapsulated in cylindrical poly(lactide-co-glycolide) implants: mechanism of stabilization by basic additives publication-title: Pharm Res doi: 10.1023/A:1007513425337 – volume: 26 start-page: 3557 issue: 17 year: 2005 ident: 10.1016/j.actbio.2014.09.008_b0175 article-title: In vivo corrosion of four magnesium alloys and the associated bone response publication-title: Biomaterials doi: 10.1016/j.biomaterials.2004.09.049 – volume: 31 start-page: 729 year: 2007 ident: 10.1016/j.actbio.2014.09.008_b0160 article-title: A comprehensive clinical review of recombinant human bone morphogenetic protein-2 (INFUSE Bone Graft) publication-title: Int Orthop doi: 10.1007/s00264-007-0418-6 – volume: 97 start-page: 3213 year: 2000 ident: 10.1016/j.actbio.2014.09.008_b0015 article-title: Rapid expansion of recycling stem cells in culture of plastic adherent cells from human bone marrow publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.97.7.3213 – volume: 17 start-page: 21 year: 1967 ident: 10.1016/j.actbio.2014.09.008_b0025 article-title: Alveolar ridge resorption following tooth extraction publication-title: J Prosthet Dent doi: 10.1016/0022-3913(67)90046-7 – volume: 38 start-page: 261 issue: 3 year: 2011 ident: 10.1016/j.actbio.2014.09.008_b0125 article-title: Wound healing/regeneration using recombinant human growth/differentiation factor-5 in an injectable poly-lactide-co-glycolide-acid composite carrier and a one-wall intra-bony defect model in dogs publication-title: J Clin Periodontol doi: 10.1111/j.1600-051X.2010.01691.x – year: 2003 ident: 10.1016/j.actbio.2014.09.008_b0240 – volume: 16 start-page: 981 issue: 6 year: 2005 ident: 10.1016/j.actbio.2014.09.008_b0105 article-title: Allograft and alloplastic bone substitutes: a review of science and technology for the craniomaxillofacial surgeon publication-title: J Craniofac Surg doi: 10.1097/01.scs.0000179662.38172.dd – volume: 25 start-page: 150 issue: 2 year: 2014 ident: 10.1016/j.actbio.2014.09.008_b0130 article-title: A randomized controlled clinical multicenter trial comparing the clinical and histological performance of a new, modified polylactide-co-glycolide acid membrane to an expanded polytetrafluorethylene membrane in guided bone regeneration procedures publication-title: Clin Oral Implant Res doi: 10.1111/clr.12132 – volume: 19 start-page: 1111 year: 2008 ident: 10.1016/j.actbio.2014.09.008_b0040 article-title: Hard tissue alterations after socket preservation: an experimental study in the beagle dog publication-title: Clin Oral Implant Res doi: 10.1111/j.1600-0501.2008.01575.x – volume: 32 start-page: 583 issue: 6 year: 2005 ident: 10.1016/j.actbio.2014.09.008_b0010 article-title: Periodontal healing in one-wall intra-bony defects in dogs following implantation of autogenous bone or a coral-derived biomaterial publication-title: J Clin Periodontol doi: 10.1111/j.1600-051X.2005.00729.x – volume: 395 start-page: 81 year: 2002 ident: 10.1016/j.actbio.2014.09.008_b0110 article-title: Properties of osteoconductive biomaterials: calcium phosphates publication-title: Clin Orthop Relat Res doi: 10.1097/00003086-200202000-00009 – volume: 9 start-page: 223 issue: 3 year: 2011 ident: 10.1016/j.actbio.2014.09.008_b0140 article-title: Degradable polymers may improve dental practice publication-title: J Appl Biomater Biomech – volume: 31 start-page: 2084 issue: 8 year: 2010 ident: 10.1016/j.actbio.2014.09.008_b0220 article-title: A biodegradable polymer-based coating to control the performance of magnesium alloy orthopaedic implants publication-title: Biomaterials doi: 10.1016/j.biomaterials.2009.11.111 – volume: 69 start-page: 1044 issue: 9 year: 1998 ident: 10.1016/j.actbio.2014.09.008_b0075 article-title: Preservation of alveolar bone in extraction sockets using bioabsorbable membranes publication-title: J Periodontol doi: 10.1902/jop.1998.69.9.1044 – volume: 19 start-page: 16 issue: 1 year: 2008 ident: 10.1016/j.actbio.2014.09.008_b0120 article-title: Polylactide and polyglycolide sponge used in human extraction sockets: bone formation following 3 months after its application publication-title: Clin Oral Implant Res doi: 10.1111/j.1600-0501.2007.01311.x – volume: 21 start-page: 688 issue: 7 year: 2010 ident: 10.1016/j.actbio.2014.09.008_b0065 article-title: Alveolar ridge preservation with guided bone regeneration and a synthetic bone substitute or a bovine-derived xenograft: a randomized, controlled clinical trial publication-title: Clin Oral Implant Res doi: 10.1111/j.1600-0501.2010.01918.x – year: 2014 ident: 10.1016/j.actbio.2014.09.008_b0180 article-title: Magnesium ion stimulation of bone marrow stromal cells enhances osteogenic activity, simulating the effect of magnesium alloy degradation publication-title: Acta Biomater doi: 10.1016/j.actbio.2014.02.002 – volume: 10 start-page: 312 year: 1996 ident: 10.1016/j.actbio.2014.09.008_b0050 article-title: Lateral ridge augmentation using autografts and barrier membranes: a clinical study with 40 partially edentulous patients publication-title: J Oral Maxillofac Surg – volume: 21 start-page: 567 year: 2009 ident: 10.1016/j.actbio.2014.09.008_b0080 article-title: Guided bone regeneration: biological principle and therapeutic applications publication-title: Clin Oral Implant Res doi: 10.1111/j.1600-0501.2010.01922.x – volume: 176 start-page: 830 issue: 11 year: 2011 ident: 10.1016/j.actbio.2014.09.008_b0235 article-title: Improved cytotoxicity testing of magnesium materials publication-title: Mater Sci Eng, B doi: 10.1016/j.mseb.2011.04.008 – volume: 35 start-page: 1068 issue: 5 year: 1994 ident: 10.1016/j.actbio.2014.09.008_b0230 article-title: Preparation and characterization of poly(l-lactic acid) foams publication-title: Polymer doi: 10.1016/0032-3861(94)90953-9 – volume: 20 start-page: 530 year: 2002 ident: 10.1016/j.actbio.2014.09.008_b0020 article-title: Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality publication-title: Stem Cells doi: 10.1634/stemcells.20-6-530 – volume: 17 start-page: 92 issue: 2 year: 1996 ident: 10.1016/j.actbio.2014.09.008_b0150 article-title: Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/polyglycolic acid copolymers publication-title: Biomaterials doi: 10.1016/0142-9612(96)85754-1 – volume: 3 start-page: 1377 issue: 3 year: 2011 ident: 10.1016/j.actbio.2014.09.008_b0145 article-title: Poly Lactic-co-Glycolic Acid (PLGA) as a biodegradable controlled drug delivery carrier publication-title: Polymers doi: 10.3390/polym3031377 – volume: 22 start-page: 802 issue: 8 year: 2011 ident: 10.1016/j.actbio.2014.09.008_b0135 article-title: Guided bone regeneration with a synthetic biodegradable membrane: a comparative study in dogs publication-title: Clin Oral Implant Res doi: 10.1111/j.1600-0501.2010.02068.x – volume: 11 start-page: 43 year: 2006 ident: 10.1016/j.actbio.2014.09.008_b0190 article-title: Collagen-hydroxyapatite composites for hard tissue repair publication-title: Eur Cells Mater doi: 10.22203/eCM.v011a06 – volume: 4 start-page: 403 issue: 4 year: 2010 ident: 10.1016/j.actbio.2014.09.008_b0005 article-title: Effect of autogenous cortical bone grafting in conjunction with guided tissue regeneration in the treatment of intraosseous periodontal defects publication-title: Eur J Dent doi: 10.1055/s-0039-1697860 – volume: 24 start-page: 85 issue: 1 year: 2013 ident: 10.1016/j.actbio.2014.09.008_b0210 article-title: Biodegradable poly(lactide-co-glycolide) coatings on magnesium alloys for orthopedic applications publication-title: J Mater Sci - Mater Med doi: 10.1007/s10856-012-4773-5 – volume: 18 start-page: 52 year: 2000 ident: 10.1016/j.actbio.2014.09.008_b0200 article-title: Stabilization of proteins encapsulated in injectable poly (lactide-co-glycolide) publication-title: Nat Biotechnol doi: 10.1038/71916 – volume: 46 start-page: 4979 issue: 13 year: 2005 ident: 10.1016/j.actbio.2014.09.008_b0245 article-title: A comparative study of porous scaffolds with cubic and spherical macropores publication-title: Polymer doi: 10.1016/j.polymer.2005.02.120 – volume: 25 start-page: 351 year: 2005 ident: 10.1016/j.actbio.2014.09.008_b0055 article-title: The use of intraorally harvested autogenous block grafts for vertical alveolar ridge augmentation: a human study publication-title: Int J Periodontics Restorative Dent
SSID	ssj0038128
Score	2.532645
Snippet	[Display omitted] Sixty percent of implant-supported dental prostheses require bone grafting to enhance bone quantity and quality prior to implant placement.... Sixty percent of implant-supported dental prostheses require bone grafting to enhance bone quantity and quality prior to implant placement. We have developed a...
SourceID	proquest pubmed crossref elsevier
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	543
SubjectTerms	Animals Bone regeneration Bone Regeneration - physiology Bones Degradation Dental implant Dental materials Devices Dogs Equipment Design Equipment Failure Analysis Female Guided Tissue Regeneration, Periodontal - instrumentation Guided Tissue Regeneration, Periodontal - methods Lactic Acid - chemistry Magnesium Magnesium - chemistry PLGA Polyglycolic Acid - chemistry Porosity Scaffolds Socket preservation Sockets Surgical implants Tissue Scaffolds Tooth Extraction - methods
Title	Porous magnesium/PLGA composite scaffolds for enhanced bone regeneration following tooth extraction
URI	https://dx.doi.org/10.1016/j.actbio.2014.09.008 https://www.ncbi.nlm.nih.gov/pubmed/25234156 https://www.proquest.com/docview/1629972217 https://www.proquest.com/docview/1647005948 https://www.proquest.com/docview/1660085852
Volume	11
WOSCitedRecordID	wos000347747900052&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1878-7568 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0038128 issn: 1742-7061 databaseCode: AIEXJ dateStart: 20050101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3JbtswECVcp4f2UHSvuwQs0JshVKIWkkejSLogCIwmLXwjKIpKHShSICvLH_S3OxQlWqgRpzn0IhgCJYia59n0ZgahD6DzSQrxv5doM8IsiognWU69hKqYagkuQTsl4ucBPTxkiwWfj0a_-1qYy4KWJbu-5uf_VdRwDoRtSmfvIG53UzgBv0HocASxw_GfBD-vakNrPZMnoMWWZozx_vzg86wljxuGlp6ulMzzqshWtt93-cuyANKqNDNUTtpG1B0FsSiqq7agqgKJTkGR17YQYujTzlQjp6aMXzbt_pabMf6ANmmS1NImbI_k2Zob_F3aWgkQs64dF-co18t6QAsYJimCeJCksHoVInCP-rbvulO8wUBzxrZbU2eEY9tBeEO_21TDKWCtgX0ZZp5tU-uztT3rv-H_ZeYc-bDntZ0Kexdh7iJ8Ltqi8R1CY87GaGf2dW_xrTfq4Ne0Y3rdPvoqzJYquPk0N3k5N0UxrTdz_Bg96sIQPLPweYJGunyKHg6aUz5DygIJOyB9NDDCDkbYwQgDjHAPI2xghIcwwg5GuIURXsPoOfqxv3f86YvXjeTwVMRZ42WZBPOpiR9KTnWQRpJwHfqaBCkBe-XHPsl4miVgNhg4ojonTIdSs1z5iumchy_QuITHeIVwyvNcySxKQwKGQ4EDQHIVZjwGpzmlKZugsH-FQnX96s3YlEJsE-AEee6qc9uv5Zb1tJeO6HxO60sKgNwtV77vhSlAJZvvbLLUIBcRJMSUo0Owv21NRG2vpG1rEhMRsZhM0EuLFrcnEpPQ5F5e33G_b9CD9f_zLRo39YV-h-6ry2a5qnfRPbpgux32_wCmkNTH
linkProvider	Elsevier
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Porous+magnesium%2FPLGA+composite+scaffolds+for+enhanced+bone+regeneration+following+tooth+extraction&rft.jtitle=Acta+biomaterialia&rft.au=Brown%2C+Andrew&rft.au=Zaky%2C+Samer&rft.au=Ray%2C+Herbert&rft.au=Sfeir%2C+Charles&rft.date=2015-01-01&rft.issn=1742-7061&rft.volume=11&rft.spage=543&rft.epage=553&rft_id=info:doi/10.1016%2Fj.actbio.2014.09.008&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_actbio_2014_09_008
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1742-7061&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1742-7061&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1742-7061&client=summon