Dimorphic histopathology of long-standing childhood-onset diabetes

Aims/hypothesis Childhood diabetes is thought to usually result from autoimmune beta cell destruction (type 1A) with eventual total loss of beta cells. Analysis of C-peptide in children characterised at diabetes onset for autoantibodies shows heterogeneous preservation of insulin secretion in long-s...

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Bibliographic Details
Published in:	Diabetologia Vol. 53; no. 4; pp. 690 - 698
Main Authors:	Gianani, R, Campbell-Thompson, M, Sarkar, S. A, Wasserfall, C, Pugliese, A, Solis, J. M, Kent, S. C, Hering, B. J, West, E, Steck, A, Bonner-Weir, S, Atkinson, M. A, Coppieters, K, von Herrath, M, Eisenbarth, G. S
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.04.2010 Springer-Verlag Springer Springer Nature B.V
Subjects:	Adolescent Adult African Americans Age of Onset Apoptosis Autoantibodies Autoantibodies - blood Autoimmune diabetes Autopsies Biological and medical sciences blood C-Peptide C-Peptide - blood Child Child, Preschool Childhood diabetes Diabetes Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - pathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Heterogeneity of diabetes Hispanic people Histocompatibility Testing Histopathology HLA DR3 HLA DR4 HLA-DR Antigens Human Physiology Humans Hyperinsulinism Hyperinsulinism - pathology immunology Insulin insulin-dependent diabetes mellitus Insulin-Secreting Cells Insulin-Secreting Cells - pathology Internal Medicine Islet autoantibodies Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Middle Aged Organ donors Pancreas Pancreas - pathology Pathology Pathology of childhood diabetes Patterns of beta cell loss Peptides Sex Characteristics Tissue Donors United States > US Islet autoantibodies Childhood diabetes Type 1 diabetes HLA DR3 HLA DR4 Autoimmune diabetes Patterns of beta cell loss Pathology of childhood diabetes Heterogeneity of diabetes Organ donors Endocrinopathy Autoimmunity Immunopathology HLA-System Langerhans islet Autoantibody Autoimmune disease Anatomic pathology Histopathology Donor β Cell Endocrine pancreas
ISSN:	0012-186X, 1432-0428, 1432-0428
Online Access:	Get full text
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