Dimorphic histopathology of long-standing childhood-onset diabetes
Aims/hypothesis Childhood diabetes is thought to usually result from autoimmune beta cell destruction (type 1A) with eventual total loss of beta cells. Analysis of C-peptide in children characterised at diabetes onset for autoantibodies shows heterogeneous preservation of insulin secretion in long-s...
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| Published in: | Diabetologia Vol. 53; no. 4; pp. 690 - 698 |
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| Main Authors: | , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Berlin/Heidelberg
Berlin/Heidelberg : Springer-Verlag
01.04.2010
Springer-Verlag Springer Springer Nature B.V |
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| ISSN: | 0012-186X, 1432-0428, 1432-0428 |
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| Abstract | Aims/hypothesis Childhood diabetes is thought to usually result from autoimmune beta cell destruction (type 1A) with eventual total loss of beta cells. Analysis of C-peptide in children characterised at diabetes onset for autoantibodies shows heterogeneous preservation of insulin secretion in long-standing diabetes. The aim of this study was to characterise the pancreases of childhood-onset diabetes in order to define the pathological basis of this heterogeneity. Methods We evaluated 20 cadaveric organ donor pancreases of childhood-onset long-term patients for disease heterogeneity and obtained corresponding C-peptide measurements. Results Pancreases from the majority of cadaveric donors contained only insulin-deficient islets (14 of 20). The remaining six patients (30%) had numerous insulin-positive cells within at least some islets, with two different histological patterns. Pattern A (which we would associate with type 1A diabetes) had lobular retention of areas with ‘abnormal' beta cells producing the apoptosis inhibitor survivin and HLA class I. In pattern B, 100% of all islets contained normal-appearing but quantitatively reduced beta cells without survivin or HLA class I. Conclusions/interpretation Our data demonstrate that C-peptide secretion in long-standing diabetic patients can be explained by two different patterns of beta cell survival, possibly reflecting different subsets of type 1 diabetes. |
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| AbstractList | Aims/hypothesis Childhood diabetes is thought to usually result from autoimmune beta cell destruction (type 1A) with eventual total loss of beta cells. Analysis of C-peptide in children characterised at diabetes onset for autoantibodies shows heterogeneous preservation of insulin secretion in long-standing diabetes. The aim of this study was to characterise the pancreases of childhood-onset diabetes in order to define the pathological basis of this heterogeneity. Methods We evaluated 20 cadaveric organ donor pancreases of childhood-onset long-term patients for disease heterogeneity and obtained corresponding C-peptide measurements. Results Pancreases from the majority of cadaveric donors contained only insulin-deficient islets (14 of 20). The remaining six patients (30%) had numerous insulin-positive cells within at least some islets, with two different histological patterns. Pattern A (which we would associate with type 1A diabetes) had lobular retention of areas with ‘abnormal' beta cells producing the apoptosis inhibitor survivin and HLA class I. In pattern B, 100% of all islets contained normal-appearing but quantitatively reduced beta cells without survivin or HLA class I. Conclusions/interpretation Our data demonstrate that C-peptide secretion in long-standing diabetic patients can be explained by two different patterns of beta cell survival, possibly reflecting different subsets of type 1 diabetes. Childhood diabetes is thought to usually result from autoimmune beta cell destruction (type 1A) with eventual total loss of beta cells. Analysis of C-peptide in children characterised at diabetes onset for autoantibodies shows heterogeneous preservation of insulin secretion in long-standing diabetes. The aim of this study was to characterise the pancreases of childhood-onset diabetes in order to define the pathological basis of this heterogeneity. We evaluated 20 cadaveric organ donor pancreases of childhood-onset long-term patients for disease heterogeneity and obtained corresponding C-peptide measurements. Pancreases from the majority of cadaveric donors contained only insulin-deficient islets (14 of 20). The remaining six patients (30%) had numerous insulin-positive cells within at least some islets, with two different histological patterns. Pattern A (which we would associate with type 1A diabetes) had lobular retention of areas with 'abnormal' beta cells producing the apoptosis inhibitor survivin and HLA class I. In pattern B, 100% of all islets contained normal-appearing but quantitatively reduced beta cells without survivin or HLA class I. Our data demonstrate that C-peptide secretion in long-standing diabetic patients can be explained by two different patterns of beta cell survival,possibly reflecting different subsets of type 1 diabetes. Aims/hypothesis Childhood diabetes is thought to usually result from autoimmune beta cell destruction (type 1A) with eventual total loss of beta cells. Analysis of C-peptide in children characterised at diabetes onset for autoantibodies shows heterogeneous preservation of insulin secretion in long-standing diabetes. The aim of this study was to characterise the pancreases of childhood-onset diabetes in order to define the pathological basis of this heterogeneity. Methods We evaluated 20 cadaveric organ donor pancreases of childhood-onset long-term patients for disease heterogeneity and obtained corresponding C-peptide measurements. Results Pancreases from the majority of cadaveric donors contained only insulin-deficient islets (14 of 20). The remaining six patients (30%) had numerous insulin-positive cells within at least some islets, with two different histological patterns. Pattern A (which we would associate with type 1A diabetes) had lobular retention of areas with ‘abnormal’ beta cells producing the apoptosis inhibitor survivin and HLA class I. In pattern B, 100% of all islets contained normal-appearing but quantitatively reduced beta cells without survivin or HLA class I. Conclusions/interpretation Our data demonstrate that C-peptide secretion in long-standing diabetic patients can be explained by two different patterns of beta cell survival, possibly reflecting different subsets of type 1 diabetes. Childhood diabetes is thought to usually result from autoimmune beta cell destruction (type 1A) with eventual total loss of beta cells. Analysis of C-peptide in children characterised at diabetes onset for autoantibodies shows heterogeneous preservation of insulin secretion in long-standing diabetes. The aim of this study was to characterise the pancreases of childhood-onset diabetes in order to define the pathological basis of this heterogeneity. We evaluated 20 cadaveric organ donor pancreases of childhood-onset long-term patients for disease heterogeneity and obtained corresponding C-peptide measurements. Pancreases from the majority of cadaveric donors contained only insulin-deficient islets (14 of 20). The remaining six patients (30%) had numerous insulin-positive cells within at least some islets, with two different histological patterns. Pattern A (which we would associate with type 1A diabetes) had lobular retention of areas with 'abnormal' beta cells producing the apoptosis inhibitor survivin and HLA class I. In pattern B, 100% of all islets contained normal-appearing but quantitatively reduced beta cells without survivin or HLA class I. Our data demonstrate that C-peptide secretion in long-standing diabetic patients can be explained by two different patterns of beta cell survival, possibly reflecting different subsets of type 1 diabetes.[PUBLICATION ABSTRACT] Childhood diabetes is thought to usually result from autoimmune beta cell destruction (type 1A) with eventual total loss of beta cells. Analysis of C-peptide in children characterised at diabetes onset for autoantibodies shows heterogeneous preservation of insulin secretion in long-standing diabetes. The aim of this study was to characterise the pancreases of childhood-onset diabetes in order to define the pathological basis of this heterogeneity.AIMS/HYPOTHESISChildhood diabetes is thought to usually result from autoimmune beta cell destruction (type 1A) with eventual total loss of beta cells. Analysis of C-peptide in children characterised at diabetes onset for autoantibodies shows heterogeneous preservation of insulin secretion in long-standing diabetes. The aim of this study was to characterise the pancreases of childhood-onset diabetes in order to define the pathological basis of this heterogeneity.We evaluated 20 cadaveric organ donor pancreases of childhood-onset long-term patients for disease heterogeneity and obtained corresponding C-peptide measurements.METHODSWe evaluated 20 cadaveric organ donor pancreases of childhood-onset long-term patients for disease heterogeneity and obtained corresponding C-peptide measurements.Pancreases from the majority of cadaveric donors contained only insulin-deficient islets (14 of 20). The remaining six patients (30%) had numerous insulin-positive cells within at least some islets, with two different histological patterns. Pattern A (which we would associate with type 1A diabetes) had lobular retention of areas with 'abnormal' beta cells producing the apoptosis inhibitor survivin and HLA class I. In pattern B, 100% of all islets contained normal-appearing but quantitatively reduced beta cells without survivin or HLA class I.RESULTSPancreases from the majority of cadaveric donors contained only insulin-deficient islets (14 of 20). The remaining six patients (30%) had numerous insulin-positive cells within at least some islets, with two different histological patterns. Pattern A (which we would associate with type 1A diabetes) had lobular retention of areas with 'abnormal' beta cells producing the apoptosis inhibitor survivin and HLA class I. In pattern B, 100% of all islets contained normal-appearing but quantitatively reduced beta cells without survivin or HLA class I.Our data demonstrate that C-peptide secretion in long-standing diabetic patients can be explained by two different patterns of beta cell survival,possibly reflecting different subsets of type 1 diabetes.CONCLUSIONS/INTERPRETATIONOur data demonstrate that C-peptide secretion in long-standing diabetic patients can be explained by two different patterns of beta cell survival,possibly reflecting different subsets of type 1 diabetes. |
| Author | Solis, J. M Wasserfall, C Gianani, R West, E Kent, S. C Bonner-Weir, S Hering, B. J Eisenbarth, G. S Coppieters, K Sarkar, S. A Pugliese, A von Herrath, M Steck, A Campbell-Thompson, M Atkinson, M. A |
| Author_xml | – sequence: 1 fullname: Gianani, R – sequence: 2 fullname: Campbell-Thompson, M – sequence: 3 fullname: Sarkar, S. A – sequence: 4 fullname: Wasserfall, C – sequence: 5 fullname: Pugliese, A – sequence: 6 fullname: Solis, J. M – sequence: 7 fullname: Kent, S. C – sequence: 8 fullname: Hering, B. J – sequence: 9 fullname: West, E – sequence: 10 fullname: Steck, A – sequence: 11 fullname: Bonner-Weir, S – sequence: 12 fullname: Atkinson, M. A – sequence: 13 fullname: Coppieters, K – sequence: 14 fullname: von Herrath, M – sequence: 15 fullname: Eisenbarth, G. S |
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| Cites_doi | 10.1210/jc.2002-020735 10.1073/pnas.0705894104 10.1111/j.0105-2896.2005.00248.x 10.1210/jc.2006-1494 10.1007/s10024-003-2014-0 10.2337/db08-0170 10.1007/BF00452061 10.1016/0090-1229(89)90115-3 10.1038/labinvest.3700323 10.1097/01.ASN.0000046029.53933.09 10.1111/j.1365-2249.2008.03864.x 10.1210/jc.2003-030180 10.1002/9780470697405.ch2 10.1056/NEJM200105243442104 10.2337/diab.14.10.619 |
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| Keywords | Islet autoantibodies Childhood diabetes Type 1 diabetes HLA DR3 HLA DR4 Autoimmune diabetes Patterns of beta cell loss Pathology of childhood diabetes Heterogeneity of diabetes Organ donors Endocrinopathy Autoimmunity Immunopathology HLA-System Langerhans islet Autoantibody Autoimmune disease Anatomic pathology Histopathology Donor β Cell Endocrine pancreas |
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| References | Njolstad, Sovk, Cuesta-Munoz (CR6) 2008; 344 Lohr, Kloppel (CR10) 2004; 30 Wang, Miao, Babu (CR7) 2007; 92 Gianani, Eisenbarth (CR3) 2005; 204 Gepts (CR11) 1965; 14 Foulis (CR17) 2008; 292 Spencer, Peakman (CR1) 2009; 155 Dotta, Eisenbarth (CR2) 1989; 50 Steck, Yu, Armstrong (CR8) 2009; 58 Jiang, Nishimura, Devor-Henneman (CR14) 2008; 57 Wenzlau, Juhl, Yu (CR15) 2007; 104 Yoon, Ko, Cho (CR18) 2003; 88 Chen, Munter, Hamm (CR16) 2003; 4 Liggins, Orlicky, Bloomquist, Gianani (CR12) 2008; 6 Hasel, Bhanot, Maier, Strater, Moller (CR13) 2005; 85 Vaxillaire, Bonnefond, Froquel (CR4) 2009; 6 Maldonado, Hampe, Gaur (CR5) 2003; 88 Foulis, Liddle, Farquharson, Richmond, Weir (CR9) 1986; 29 PR Njolstad (1642_CR6) 2008; 344 M Maldonado (1642_CR5) 2003; 88 KH Yoon (1642_CR18) 2003; 88 R Gianani (1642_CR3) 2005; 204 C Liggins (1642_CR12) 2008; 6 M Vaxillaire (1642_CR4) 2009; 6 J Chen (1642_CR16) 2003; 4 M Lohr (1642_CR10) 2004; 30 J Wang (1642_CR7) 2007; 92 JM Wenzlau (1642_CR15) 2007; 104 KA Steck (1642_CR8) 2009; 58 F Dotta (1642_CR2) 1989; 50 AK Foulis (1642_CR9) 1986; 29 Y Jiang (1642_CR14) 2008; 57 W Gepts (1642_CR11) 1965; 14 AK Foulis (1642_CR17) 2008; 292 J Spencer (1642_CR1) 2009; 155 C Hasel (1642_CR13) 2005; 85 15790362 - Immunol Rev. 2005 Apr;204:232-49 2642771 - Clin Immunol Immunopathol. 1989 Jan;50(1 Pt 2):S85-95 16127431 - Lab Invest. 2005 Oct;85(10):1263-75 12727989 - J Clin Endocrinol Metab. 2003 May;88(5):2300-8 19396026 - Pediatr Endocrinol Rev. 2009 Mar;6(3):405-17 12538749 - J Am Soc Nephrol. 2003 Feb;14(2):469-77 11372010 - N Engl J Med. 2001 May 24;344(21):1588-92 17062766 - J Clin Endocrinol Metab. 2007 Jan;92(1):88-92 3322901 - Diabetologia. 1987 Oct;30(10):757-62 18599523 - Diabetes. 2008 Oct;57(10):2718-27 Diabetologia. 2010 Aug;53(8):1811-2 19203089 - Novartis Found Symp. 2008;292:2-13; discussion 13-8, 122-9, 202-3 19128357 - Clin Exp Immunol. 2009 Feb;155(2):125-7 14602731 - J Clin Endocrinol Metab. 2003 Nov;88(11):5090-8 3522324 - Diabetologia. 1986 May;29(5):267-74 14708732 - Pediatr Dev Pathol. 2003 Sep-Oct;6(5):392-7 5318831 - Diabetes. 1965 Oct;14(10):619-33 17942684 - Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17040-5 |
| References_xml | – volume: 88 start-page: 2300 year: 2003 end-page: 2308 ident: CR18 article-title: Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2002-020735 – volume: 104 start-page: 17040 year: 2007 end-page: 17045 ident: CR15 article-title: The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabets publication-title: PNAS doi: 10.1073/pnas.0705894104 – volume: 204 start-page: 232 year: 2005 end-page: 249 ident: CR3 article-title: The stages of type 1A diabetes: 2005 publication-title: Immunol Rev doi: 10.1111/j.0105-2896.2005.00248.x – volume: 92 start-page: 88 year: 2007 end-page: 92 ident: CR7 article-title: Prevalence of autoantibody-negative diabetes is not rare at all ages and increases with older age and obesity publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2006-1494 – volume: 6 start-page: 392 year: 2008 end-page: 397 ident: CR12 article-title: Developmentally regulated expression of survivin in human pancreatic islets publication-title: Pediatr Dev Pathol doi: 10.1007/s10024-003-2014-0 – volume: 6 start-page: 405 year: 2009 end-page: 417 ident: CR4 article-title: Breakthroughs in monogenic diabetes genetics: from pediatric forms to young adulthood diabetes publication-title: Pediatr Endocrinol Rev – volume: 57 start-page: 2718 year: 2008 end-page: 2727 ident: CR14 article-title: Postnatal expansion of the pancreatic beta-cell mass is dependent on survivin publication-title: Diabetes doi: 10.2337/db08-0170 – volume: 29 start-page: 267 year: 1986 end-page: 274 ident: CR9 article-title: The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom publication-title: Diabetologia doi: 10.1007/BF00452061 – volume: 50 start-page: 85 year: 1989 end-page: 95 ident: CR2 article-title: Type I diabetes mellitus: a predictable autoimmune disease with interindividual variation in the rate of beta cell destruction publication-title: Clin Immunol Immunopathol doi: 10.1016/0090-1229(89)90115-3 – volume: 85 start-page: 1263 year: 2005 end-page: 1275 ident: CR13 article-title: Parenchymal regression in chronic pancreatitis spares islets reprogrammed for the expression of NF kappa B and IAPs publication-title: Lab Invest doi: 10.1038/labinvest.3700323 – volume: 58 start-page: A459 issue: Suppl 1 year: 2009 ident: CR8 article-title: C-peptide levels correlate with age of onset, duration of diabetes and autoantibody status publication-title: Diabetes – volume: 4 start-page: 469 year: 2003 end-page: 477 ident: CR16 article-title: Insulin resistance and risk of chronic kidney disease in nondiabetic US adults publication-title: J Am Soc Nephrol doi: 10.1097/01.ASN.0000046029.53933.09 – volume: 155 start-page: 125 year: 2009 end-page: 127 ident: CR1 article-title: Post-mortem analysis of islet pathology in type 1 diabetes illuminates the life and death of the beta cell publication-title: Clin Exp Immunol doi: 10.1111/j.1365-2249.2008.03864.x – volume: 88 start-page: 5090 year: 2003 end-page: 5098 ident: CR5 article-title: Ketosis-prone diabetes: dissection of a heterogeneous syndrome using an immunogenetic and beta-cell functional classsification, prospective analysis, and clinical outcomes publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2003-030180 – volume: 30 start-page: 757 year: 2004 end-page: 762 ident: CR10 article-title: Residual insulin positivity and pancreatic atrophy in relation to duration of chronic type 1 (insulin-dependent) diabetes mellitus and microangiopathy publication-title: Diabetologia – volume: 14 start-page: 619 year: 1965 end-page: 633 ident: CR11 article-title: Pathologic anatomy of the pancreas in juvenile diabetes mellitus publication-title: Diabetes – volume: 292 start-page: 2 year: 2008 end-page: 13 ident: CR17 article-title: Pancreatic pathology in type 1 diabetes in humans publication-title: Novartis Found Symp doi: 10.1002/9780470697405.ch2 – volume: 344 start-page: 1588 year: 2008 end-page: 1592 ident: CR6 article-title: Neonatal diabetes mellitus due to complete glucokinase deficiency publication-title: N Engl J Med doi: 10.1056/NEJM200105243442104 – volume: 6 start-page: 392 year: 2008 ident: 1642_CR12 publication-title: Pediatr Dev Pathol doi: 10.1007/s10024-003-2014-0 – volume: 58 start-page: A459 issue: Suppl 1 year: 2009 ident: 1642_CR8 publication-title: Diabetes – volume: 57 start-page: 2718 year: 2008 ident: 1642_CR14 publication-title: Diabetes doi: 10.2337/db08-0170 – volume: 4 start-page: 469 year: 2003 ident: 1642_CR16 publication-title: J Am Soc Nephrol doi: 10.1097/01.ASN.0000046029.53933.09 – volume: 204 start-page: 232 year: 2005 ident: 1642_CR3 publication-title: Immunol Rev doi: 10.1111/j.0105-2896.2005.00248.x – volume: 88 start-page: 5090 year: 2003 ident: 1642_CR5 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2003-030180 – volume: 344 start-page: 1588 year: 2008 ident: 1642_CR6 publication-title: N Engl J Med doi: 10.1056/NEJM200105243442104 – volume: 30 start-page: 757 year: 2004 ident: 1642_CR10 publication-title: Diabetologia – volume: 85 start-page: 1263 year: 2005 ident: 1642_CR13 publication-title: Lab Invest doi: 10.1038/labinvest.3700323 – volume: 104 start-page: 17040 year: 2007 ident: 1642_CR15 publication-title: PNAS doi: 10.1073/pnas.0705894104 – volume: 155 start-page: 125 year: 2009 ident: 1642_CR1 publication-title: Clin Exp Immunol doi: 10.1111/j.1365-2249.2008.03864.x – volume: 88 start-page: 2300 year: 2003 ident: 1642_CR18 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2002-020735 – volume: 92 start-page: 88 year: 2007 ident: 1642_CR7 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2006-1494 – volume: 14 start-page: 619 year: 1965 ident: 1642_CR11 publication-title: Diabetes doi: 10.2337/diab.14.10.619 – volume: 50 start-page: 85 year: 1989 ident: 1642_CR2 publication-title: Clin Immunol Immunopathol doi: 10.1016/0090-1229(89)90115-3 – volume: 292 start-page: 2 year: 2008 ident: 1642_CR17 publication-title: Novartis Found Symp doi: 10.1002/9780470697405.ch2 – volume: 6 start-page: 405 year: 2009 ident: 1642_CR4 publication-title: Pediatr Endocrinol Rev – volume: 29 start-page: 267 year: 1986 ident: 1642_CR9 publication-title: Diabetologia doi: 10.1007/BF00452061 – reference: 16127431 - Lab Invest. 2005 Oct;85(10):1263-75 – reference: 12727989 - J Clin Endocrinol Metab. 2003 May;88(5):2300-8 – reference: 2642771 - Clin Immunol Immunopathol. 1989 Jan;50(1 Pt 2):S85-95 – reference: - Diabetologia. 2010 Aug;53(8):1811-2 – reference: 12538749 - J Am Soc Nephrol. 2003 Feb;14(2):469-77 – reference: 19396026 - Pediatr Endocrinol Rev. 2009 Mar;6(3):405-17 – reference: 3322901 - Diabetologia. 1987 Oct;30(10):757-62 – reference: 15790362 - Immunol Rev. 2005 Apr;204:232-49 – reference: 19203089 - Novartis Found Symp. 2008;292:2-13; discussion 13-8, 122-9, 202-3 – reference: 14602731 - J Clin Endocrinol Metab. 2003 Nov;88(11):5090-8 – reference: 17942684 - Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17040-5 – reference: 11372010 - N Engl J Med. 2001 May 24;344(21):1588-92 – reference: 14708732 - Pediatr Dev Pathol. 2003 Sep-Oct;6(5):392-7 – reference: 5318831 - Diabetes. 1965 Oct;14(10):619-33 – reference: 17062766 - J Clin Endocrinol Metab. 2007 Jan;92(1):88-92 – reference: 3522324 - Diabetologia. 1986 May;29(5):267-74 – reference: 19128357 - Clin Exp Immunol. 2009 Feb;155(2):125-7 – reference: 18599523 - Diabetes. 2008 Oct;57(10):2718-27 |
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| Snippet | Aims/hypothesis Childhood diabetes is thought to usually result from autoimmune beta cell destruction (type 1A) with eventual total loss of beta cells.... Aims/hypothesis Childhood diabetes is thought to usually result from autoimmune beta cell destruction (type 1A) with eventual total loss of beta cells.... Childhood diabetes is thought to usually result from autoimmune beta cell destruction (type 1A) with eventual total loss of beta cells. Analysis of C-peptide... |
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| SubjectTerms | Adolescent Adult African Americans Age of Onset Apoptosis Autoantibodies Autoantibodies - blood Autoimmune diabetes Autopsies Biological and medical sciences blood C-Peptide C-Peptide - blood Child Child, Preschool Childhood diabetes Diabetes Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - pathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Heterogeneity of diabetes Hispanic people Histocompatibility Testing Histopathology HLA DR3 HLA DR4 HLA-DR Antigens Human Physiology Humans Hyperinsulinism Hyperinsulinism - pathology immunology Insulin insulin-dependent diabetes mellitus Insulin-Secreting Cells Insulin-Secreting Cells - pathology Internal Medicine Islet autoantibodies Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Middle Aged Organ donors Pancreas Pancreas - pathology Pathology Pathology of childhood diabetes Patterns of beta cell loss Peptides Sex Characteristics Tissue Donors |
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| Title | Dimorphic histopathology of long-standing childhood-onset diabetes |
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