CD39 Expression Identifies Terminally Exhausted CD8+ T Cells

Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit immunity to chronic viral infection. Defining novel markers of exhaustion is important both for identifying and potentially reversing T cell exhaustion. Herein, we show that the ectonucleotidse CD39 is a...

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Veröffentlicht in:	PLoS pathogens Jg. 11; H. 10; S. e1005177
Hauptverfasser:	Gupta, Prakash K., Godec, Jernej, Wolski, David, Adland, Emily, Yates, Kathleen, Pauken, Kristen E., Cosgrove, Cormac, Ledderose, Carola, Junger, Wolfgang G., Robson, Simon C., Wherry, E. John, Alter, Galit, Goulder, Philip J. R., Klenerman, Paul, Sharpe, Arlene H., Lauer, Georg M., Haining, W. Nicholas
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 01.10.2015 Public Library of Science (PLoS)
Schlagworte:	Adenosine Animals Antigens Antigens, CD - immunology Apyrase - immunology Arenaviridae Infections - immunology Biomarkers CD8-Positive T-Lymphocytes - immunology Chromatography, High Pressure Liquid Chronic Disease Disease Models, Animal Flow Cytometry Funding Hepatitis C, Chronic - immunology HIV HIV Infections - immunology Human immunodeficiency virus Humans Infections Laboratory animals Lymphocytes Lymphocytic Choriomeningitis - immunology Lymphocytic choriomeningitis virus - immunology Mice Mice, Inbred C57BL Oligonucleotide Array Sequence Analysis Pathogens Population RNA Virus Infections - immunology T cell receptors T-Lymphocyte Subsets - immunology Transcription factors Viral infections
ISSN:	1553-7374, 1553-7366, 1553-7374
Online-Zugang:	Volltext
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