A randomized phase II trial evaluating safety and efficacy of an experimental chemotherapy regimen (irinotecan + oxaliplatin, IRINOX) and two standard arms (LV5 FU2 + irinotecan or LV5 FU2 + oxaliplatin) in first-line metastatic colorectal cancer: a study of the Digestive Group of the Fédération Nationale des Centres de Lutte Contre le Cancer

To assess activity and safety of an experimental combination of irinotecan and oxaliplatin (IRINOX) as first-line treatment in advanced colorectal cancer. In this randomized phase II trial, 80 patients were treated: arm A (IRINOX) in 40 patients received at day 1 oxaliplatin 85 mg/m(2) and irinoteca...

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Bibliographic Details

Published in:	Annals of oncology Vol. 18; no. 12; p. 2000
Main Authors:	Bécouarn, Y, Senesse, P, Thézenas, S, Boucher, E, Adenis, A, Cany, L, Jacob, J H, Cvitkovic, F, Montoto-Grillot, C, Ychou, M
Format:	Journal Article
Language:	English
Published:	England 01.12.2007
Subjects:	Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Camptothecin - administration & dosage Camptothecin - analogs & derivatives Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Fluorouracil - administration & dosage Humans Irinotecan Neoplasm Metastasis Organoplatinum Compounds - administration & dosage Oxaliplatin
ISSN:	1569-8041, 1569-8041
Online Access:	Get more information
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