3D biomaterial models of human brain disease

Inherent limitations of the traditional approaches to study brain function and disease, such as rodent models and 2D cell culture platforms, have led to the development of 3D in vitro cell culture systems. These systems, products of multidisciplinary efforts encompassing stem cell biology, materials...

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Podrobná bibliografie
Vydáno v:	Neurochemistry international Ročník 147; s. 105043
Hlavní autoři:	Kajtez, Janko, Nilsson, Fredrik, Fiorenzano, Alessandro, Parmar, Malin, Emnéus, Jenny
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Elsevier Ltd 01.07.2021
Témata:	3D culture Animals Basic Medicine Biocompatible Materials - analysis Biocompatible Materials - chemistry Biomaterials Biomaterials Science Biomaterialvetenskap Brain disease Brain Diseases - drug therapy Brain ECM Brain organoids Cell Culture Techniques - methods Cell Culture Techniques, Three Dimensional Extracellular Matrix - metabolism Humans Hydrogels Hydrogels - analysis Hydrogels - chemistry Medical and Health Sciences Medical Biotechnology Medicin och hälsovetenskap Medicinsk bioteknologi Medicinska och farmaceutiska grundvetenskaper Neurosciences Neurovetenskaper 3D culture Hydrogels Brain ECM Brain disease Brain organoids Biomaterials
ISSN:	0197-0186, 1872-9754, 1872-9754
On-line přístup:	Získat plný text
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Popis
Shrnutí:	Inherent limitations of the traditional approaches to study brain function and disease, such as rodent models and 2D cell culture platforms, have led to the development of 3D in vitro cell culture systems. These systems, products of multidisciplinary efforts encompassing stem cell biology, materials engineering, and biofabrication, have quickly shown great potential to mimic biochemical composition, structural properties, and cellular morphology and diversity found in the native brain tissue. Crucial to these developments have been the advancements in stem cell technology and cell reprogramming protocols that allow reproducible generation of human subtype-specific neurons and glia in laboratory conditions. At the same time, biomaterials have been designed to provide cells in 3D with a microenvironment that mimics functional and structural aspects of the native extracellular matrix with increasing fidelity. In this article, we review the use of biomaterials in 3D in vitro models of neurological disorders with focus on hydrogel technology and with biochemical composition and physical properties of the in vivo environment as reference. •Extracellular matrix plays a crucial role in healthy and diseased brain.•Biochemical and mechanical properties of the native brain extracellular matrix are unique.•Biomaterials, in particular hydrogels, mimic aspects of brain extracellular matrix in vitro.•Natural and synthetic hydrogels allow generation of 3D in vitro models of brain disease.•Hybrid bioengineering technologies are developed to enhance 3D hydrogel cultures.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	0197-0186 1872-9754 1872-9754
DOI:	10.1016/j.neuint.2021.105043