Imaging mass cytometry reveals the prominent role of myeloid cells at the maternal-fetal interface

Although the immunological complexity of the maternal-fetal interface is well appreciated, the actual interaction of maternal immune cells and fetal trophoblasts is insufficiently understood. To comprehend the composition and spatial orientation of maternal immune cells and fetal extravillous tropho...

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Veröffentlicht in:	iScience Jg. 25; H. 7; S. 104648
Hauptverfasser:	Krop, Juliette, van der Zwan, Anita, Ijsselsteijn, Marieke E., Kapsenberg, Hanneke, Luk, Sietse J., Hendriks, Sanne H., van der Keur, Carin, Verleng, Lotte J., Somarakis, Antonis, van der Meeren, Lotte, Haasnoot, Geert, Bos, Manon, de Miranda, Noel F.C.C., Chuva de Sousa Lopes, Susana M., van der Hoorn, Marie-Louise P., Koning, Frits, Claas, Frans H.J., Heidt, Sebastiaan, Eikmans, Michael
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Elsevier Inc 15.07.2022 Elsevier
Schlagworte:	Biological sciences Biological sciences research methodologies Biotechnology Immunology Biotechnology Biological sciences Immunology Biological sciences research methodologies
ISSN:	2589-0042, 2589-0042
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Abstract	Although the immunological complexity of the maternal-fetal interface is well appreciated, the actual interaction of maternal immune cells and fetal trophoblasts is insufficiently understood. To comprehend the composition and spatial orientation of maternal immune cells and fetal extravillous trophoblasts, we applied imaging mass cytometry on decidua basalis of the three trimesters of healthy pregnancy. Within all trimesters, we observed considerably higher frequencies of myeloid cells in the decidua than is seen with single-cell suspension techniques. Moreover, they were the most pronounced cell type in the microenvironment of other decidual cells. In first trimester, HLA-DR- macrophages represented the most abundant myeloid subcluster and these cells were frequently observed in the vicinity of trophoblasts. At term, HLA-DR+ macrophage subclusters were abundantly present and frequently observed in the microenvironment of T cells. Taken together, our results highlight the dynamic role of myeloid cells at the human maternal-fetal interface throughout gestation. [Display omitted] •Frequency of myeloid cells is underestimated after tissue digestion•Myeloid cells could support NK cells with proper trophoblast invasion•Myeloid cells are dynamic in their role throughout gestation Biological sciences; Immunology; Biotechnology; Biological sciences research methodologies
AbstractList	Although the immunological complexity of the maternal-fetal interface is well appreciated, the actual interaction of maternal immune cells and fetal trophoblasts is insufficiently understood. To comprehend the composition and spatial orientation of maternal immune cells and fetal extravillous trophoblasts, we applied imaging mass cytometry on decidua basalis of the three trimesters of healthy pregnancy. Within all trimesters, we observed considerably higher frequencies of myeloid cells in the decidua than is seen with single-cell suspension techniques. Moreover, they were the most pronounced cell type in the microenvironment of other decidual cells. In first trimester, HLA-DR- macrophages represented the most abundant myeloid subcluster and these cells were frequently observed in the vicinity of trophoblasts. At term, HLA-DR+ macrophage subclusters were abundantly present and frequently observed in the microenvironment of T cells. Taken together, our results highlight the dynamic role of myeloid cells at the human maternal-fetal interface throughout gestation. Although the immunological complexity of the maternal-fetal interface is well appreciated, the actual interaction of maternal immune cells and fetal trophoblasts is insufficiently understood. To comprehend the composition and spatial orientation of maternal immune cells and fetal extravillous trophoblasts, we applied imaging mass cytometry on decidua basalis of the three trimesters of healthy pregnancy. Within all trimesters, we observed considerably higher frequencies of myeloid cells in the decidua than is seen with single-cell suspension techniques. Moreover, they were the most pronounced cell type in the microenvironment of other decidual cells. In first trimester, HLA-DR- macrophages represented the most abundant myeloid subcluster and these cells were frequently observed in the vicinity of trophoblasts. At term, HLA-DR+ macrophage subclusters were abundantly present and frequently observed in the microenvironment of T cells. Taken together, our results highlight the dynamic role of myeloid cells at the human maternal-fetal interface throughout gestation. • Frequency of myeloid cells is underestimated after tissue digestion • Myeloid cells could support NK cells with proper trophoblast invasion • Myeloid cells are dynamic in their role throughout gestation Biological sciences; Immunology; Biotechnology; Biological sciences research methodologies Although the immunological complexity of the maternal-fetal interface is well appreciated, the actual interaction of maternal immune cells and fetal trophoblasts is insufficiently understood. To comprehend the composition and spatial orientation of maternal immune cells and fetal extravillous trophoblasts, we applied imaging mass cytometry on decidua basalis of the three trimesters of healthy pregnancy. Within all trimesters, we observed considerably higher frequencies of myeloid cells in the decidua than is seen with single-cell suspension techniques. Moreover, they were the most pronounced cell type in the microenvironment of other decidual cells. In first trimester, HLA-DR- macrophages represented the most abundant myeloid subcluster and these cells were frequently observed in the vicinity of trophoblasts. At term, HLA-DR+ macrophage subclusters were abundantly present and frequently observed in the microenvironment of T cells. Taken together, our results highlight the dynamic role of myeloid cells at the human maternal-fetal interface throughout gestation. [Display omitted] •Frequency of myeloid cells is underestimated after tissue digestion•Myeloid cells could support NK cells with proper trophoblast invasion•Myeloid cells are dynamic in their role throughout gestation Biological sciences; Immunology; Biotechnology; Biological sciences research methodologies Although the immunological complexity of the maternal-fetal interface is well appreciated, the actual interaction of maternal immune cells and fetal trophoblasts is insufficiently understood. To comprehend the composition and spatial orientation of maternal immune cells and fetal extravillous trophoblasts, we applied imaging mass cytometry on decidua basalis of the three trimesters of healthy pregnancy. Within all trimesters, we observed considerably higher frequencies of myeloid cells in the decidua than is seen with single-cell suspension techniques. Moreover, they were the most pronounced cell type in the microenvironment of other decidual cells. In first trimester, HLA-DR- macrophages represented the most abundant myeloid subcluster and these cells were frequently observed in the vicinity of trophoblasts. At term, HLA-DR+ macrophage subclusters were abundantly present and frequently observed in the microenvironment of T cells. Taken together, our results highlight the dynamic role of myeloid cells at the human maternal-fetal interface throughout gestation.Although the immunological complexity of the maternal-fetal interface is well appreciated, the actual interaction of maternal immune cells and fetal trophoblasts is insufficiently understood. To comprehend the composition and spatial orientation of maternal immune cells and fetal extravillous trophoblasts, we applied imaging mass cytometry on decidua basalis of the three trimesters of healthy pregnancy. Within all trimesters, we observed considerably higher frequencies of myeloid cells in the decidua than is seen with single-cell suspension techniques. Moreover, they were the most pronounced cell type in the microenvironment of other decidual cells. In first trimester, HLA-DR- macrophages represented the most abundant myeloid subcluster and these cells were frequently observed in the vicinity of trophoblasts. At term, HLA-DR+ macrophage subclusters were abundantly present and frequently observed in the microenvironment of T cells. Taken together, our results highlight the dynamic role of myeloid cells at the human maternal-fetal interface throughout gestation.
ArticleNumber	104648
Author	Verleng, Lotte J. Kapsenberg, Hanneke Krop, Juliette van der Zwan, Anita Eikmans, Michael Bos, Manon Heidt, Sebastiaan van der Hoorn, Marie-Louise P. Ijsselsteijn, Marieke E. Haasnoot, Geert Chuva de Sousa Lopes, Susana M. van der Meeren, Lotte de Miranda, Noel F.C.C. Somarakis, Antonis Luk, Sietse J. Koning, Frits Claas, Frans H.J. Hendriks, Sanne H. van der Keur, Carin
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Snippet	Although the immunological complexity of the maternal-fetal interface is well appreciated, the actual interaction of maternal immune cells and fetal...
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Title	Imaging mass cytometry reveals the prominent role of myeloid cells at the maternal-fetal interface
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