Treatment and management of cognitive dysfunction in patients with multiple sclerosis

Cognitive impairment is a common and devastating manifestation of multiple sclerosis (MS). Although disease-modifying therapies have been efficacious for reducing relapse rates in MS, such treatments are ineffective for treating cognitive dysfunction. Alternative treatment approaches for mitigating...

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Bibliographic Details
Published in:Nature reviews. Neurology Vol. 16; no. 6; pp. 319 - 332
Main Authors: DeLuca, John, Chiaravalloti, Nancy D, Sandroff, Brian M
Format: Journal Article
Language:English
Published: England Nature Publishing Group 01.06.2020
Subjects:
Cognitive ability
Cognitive Behavioral Therapy - methods
Cognitive Behavioral Therapy - trends
Cognitive Dysfunction - epidemiology
Cognitive Dysfunction - psychology
Cognitive Dysfunction - therapy
Disease Management
Fitness training programs
Humans
Multiple sclerosis
Multiple Sclerosis - epidemiology
Multiple Sclerosis - psychology
Multiple Sclerosis - therapy
Neuropsychological Tests
Rehabilitation
Therapy, Computer-Assisted - methods
Therapy, Computer-Assisted - trends
Treatment Outcome
ISSN:1759-4758, 1759-4766, 1759-4766
Online Access:Get full text
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Summary:Cognitive impairment is a common and devastating manifestation of multiple sclerosis (MS). Although disease-modifying therapies have been efficacious for reducing relapse rates in MS, such treatments are ineffective for treating cognitive dysfunction. Alternative treatment approaches for mitigating cognitive problems are greatly needed in this population. To date, cognitive rehabilitation and exercise training have been identified as possible candidates for treating MS-related cognitive impairment; however, cognitive dysfunction is still often considered to be poorly managed in patients with MS. This Review provides a comprehensive overview of recent developments in the treatment and management of cognitive impairment in people with MS. We describe the theoretical rationales, current states of the science, field-wide challenges and recent advances in cognitive rehabilitation and exercise training for treating MS-related cognitive impairment. We also discuss future directions for research into the treatment of cognitive impairment in MS that should set the stage for the inclusion of cognitive rehabilitation and exercise training into clinical practice within the next decade.
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ISSN:1759-4758
1759-4766
1759-4766
DOI:10.1038/s41582-020-0355-1