Peripheral and central pathogenesis of postherpetic neuralgia

Background Postherpetic neuralgia (PHN) is a classic chronic condition with multiple signs of peripheral and central neuropathy. Unfortunately, the pathogenesis of PHN is not well defined, limiting clinical treatment and disease management. Objective To describe the peripheral and central pathologic...

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Veröffentlicht in:Skin research and technology Jg. 30; H. 8; S. e13867 - n/a
Hauptverfasser: Liu, Qiuping, Han, Jingxian, Zhang, Xuezhu
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England John Wiley & Sons, Inc 01.08.2024
John Wiley and Sons Inc
Schlagworte:
Brain - pathology
Brain - physiopathology
Brain injury
central
Central nervous system
Central Nervous System Sensitization - physiology
Humans
Injury prevention
mechanism
Neuralgia
Neuralgia, Postherpetic - physiopathology
Neuropathy
Original
Pathogenesis
peripheral
Peripheral Nerve Injuries - physiopathology
Peripheral nerves
Peripheral neuropathy
postherpetic neuralgia
Structural analysis
Structure-function relationships
postherpetic neuralgia
peripheral
central
mechanism
ISSN:0909-752X, 1600-0846, 1600-0846
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Zusammenfassung:Background Postherpetic neuralgia (PHN) is a classic chronic condition with multiple signs of peripheral and central neuropathy. Unfortunately, the pathogenesis of PHN is not well defined, limiting clinical treatment and disease management. Objective To describe the peripheral and central pathological axes of PHN, including peripheral nerve injury, inflammation induction, central nervous system sensitization, and brain functional and structural network activity. Methods A bibliographic survey was carried out, selecting relevant articles that evaluated the characterization of the pathogenesis of PHN, including peripheral and central pathological axes. Results Currently, due to the complexity of the pathophysiological mechanisms of PHN and the incomplete understanding of the exact mechanism of neuralgia. Conclusion It is essential to conduct in‐depth research to clarify the origins of PHN pathogenesis and explore effective and comprehensive therapies for PHN.
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ISSN:0909-752X
1600-0846
1600-0846
DOI:10.1111/srt.13867