Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase

Approximately one-quarter of people over the age of 65 are estimated to suffer some form of cognitive impairment, underscoring the need for effective cognitive-enhancing agents. Insulin-regulated aminopeptidase (IRAP) is potentially an innovative target for the development of cognitive enhancers, as...

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Veröffentlicht in:	The FASEB journal Jg. 22; H. 12; S. 4209
Hauptverfasser:	Albiston, Anthony L, Morton, Craig J, Ng, Hooi Ling, Pham, Vi, Yeatman, Holly R, Ye, Siying, Fernando, Ruani N, De Bundel, Dimitri, Ascher, David B, Mendelsohn, Frederick A O, Parker, Michael W, Chai, Siew Yeen
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.12.2008
Schlagworte:	Animals Biological Assay Catalytic Domain Cystinyl Aminopeptidase - antagonists & inhibitors Drug Design Enzyme Inhibitors - pharmacology Male Memory - drug effects Models, Molecular Nootropic Agents - pharmacology Rats Rats, Sprague-Dawley Recognition (Psychology) - drug effects
ISSN:	1530-6860, 1530-6860
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