Aortic-brachial stiffness mismatch and mortality in dialysis population
We hypothesized that increased aortic stiffness (central elastic artery) combined with a decrease in brachial stiffness (peripheral muscular artery) leads to the reversal of the physiological stiffness gradient (ie, mismatch), promoting end-organ damages through increased forward pressure wave trans...
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| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Jg. 65; H. 2; S. 378 |
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| Sprache: | Englisch |
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01.02.2015
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| ISSN: | 1524-4563, 1524-4563 |
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| Abstract | We hypothesized that increased aortic stiffness (central elastic artery) combined with a decrease in brachial stiffness (peripheral muscular artery) leads to the reversal of the physiological stiffness gradient (ie, mismatch), promoting end-organ damages through increased forward pressure wave transmission into the microcirculation. We, therefore, examined the effect of aortic-brachial stiffness mismatch on mortality in patients in need of dialysis. In a prospective observational study, aortic-brachial arterial stiffness mismatch (pulse wave velocity ratio) was assessed using carotid-femoral pulse wave velocity divided by carotid-radial pulse wave velocity in 310 adult patients on dialysis. After a median follow-up of 29 months, 146 (47%) deaths occurred. The hazard ratio (HR) for mortality related to PWV ratio in a Cox regression analysis was 1.43 (95% confidence interval [CI], 1.24-1.64; P<0.001 per 1 SD) and was still significant after adjustments for confounding factors, such as age, dialysis vintage, sex, cardiovascular disease, diabetes mellitus, smoking status, and weight (HR, 1.23; 95% CI: 1.02-1.49). The HRs for changes in 1 SD of augmentation index (HR, 1.35; 95% CI, 1.12-1.63), carotid-femoral pulse wave velocity (HR, 1.29; 95% CI, 1.11-1.50), and carotid-radial pulse wave velocity (HR, 0.80; 95% CI, 0.67-0.95) were statistically significant in univariate analysis, but were no longer statistically significant after adjustment for age. In conclusion, aortic-brachial arterial stiffness mismatch was strongly and independently associated with increased mortality in this dialysis population. Further studies are required to confirm these finding in lower-risk groups. |
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| AbstractList | We hypothesized that increased aortic stiffness (central elastic artery) combined with a decrease in brachial stiffness (peripheral muscular artery) leads to the reversal of the physiological stiffness gradient (ie, mismatch), promoting end-organ damages through increased forward pressure wave transmission into the microcirculation. We, therefore, examined the effect of aortic-brachial stiffness mismatch on mortality in patients in need of dialysis. In a prospective observational study, aortic-brachial arterial stiffness mismatch (pulse wave velocity ratio) was assessed using carotid-femoral pulse wave velocity divided by carotid-radial pulse wave velocity in 310 adult patients on dialysis. After a median follow-up of 29 months, 146 (47%) deaths occurred. The hazard ratio (HR) for mortality related to PWV ratio in a Cox regression analysis was 1.43 (95% confidence interval [CI], 1.24-1.64; P<0.001 per 1 SD) and was still significant after adjustments for confounding factors, such as age, dialysis vintage, sex, cardiovascular disease, diabetes mellitus, smoking status, and weight (HR, 1.23; 95% CI: 1.02-1.49). The HRs for changes in 1 SD of augmentation index (HR, 1.35; 95% CI, 1.12-1.63), carotid-femoral pulse wave velocity (HR, 1.29; 95% CI, 1.11-1.50), and carotid-radial pulse wave velocity (HR, 0.80; 95% CI, 0.67-0.95) were statistically significant in univariate analysis, but were no longer statistically significant after adjustment for age. In conclusion, aortic-brachial arterial stiffness mismatch was strongly and independently associated with increased mortality in this dialysis population. Further studies are required to confirm these finding in lower-risk groups.We hypothesized that increased aortic stiffness (central elastic artery) combined with a decrease in brachial stiffness (peripheral muscular artery) leads to the reversal of the physiological stiffness gradient (ie, mismatch), promoting end-organ damages through increased forward pressure wave transmission into the microcirculation. We, therefore, examined the effect of aortic-brachial stiffness mismatch on mortality in patients in need of dialysis. In a prospective observational study, aortic-brachial arterial stiffness mismatch (pulse wave velocity ratio) was assessed using carotid-femoral pulse wave velocity divided by carotid-radial pulse wave velocity in 310 adult patients on dialysis. After a median follow-up of 29 months, 146 (47%) deaths occurred. The hazard ratio (HR) for mortality related to PWV ratio in a Cox regression analysis was 1.43 (95% confidence interval [CI], 1.24-1.64; P<0.001 per 1 SD) and was still significant after adjustments for confounding factors, such as age, dialysis vintage, sex, cardiovascular disease, diabetes mellitus, smoking status, and weight (HR, 1.23; 95% CI: 1.02-1.49). The HRs for changes in 1 SD of augmentation index (HR, 1.35; 95% CI, 1.12-1.63), carotid-femoral pulse wave velocity (HR, 1.29; 95% CI, 1.11-1.50), and carotid-radial pulse wave velocity (HR, 0.80; 95% CI, 0.67-0.95) were statistically significant in univariate analysis, but were no longer statistically significant after adjustment for age. In conclusion, aortic-brachial arterial stiffness mismatch was strongly and independently associated with increased mortality in this dialysis population. Further studies are required to confirm these finding in lower-risk groups. We hypothesized that increased aortic stiffness (central elastic artery) combined with a decrease in brachial stiffness (peripheral muscular artery) leads to the reversal of the physiological stiffness gradient (ie, mismatch), promoting end-organ damages through increased forward pressure wave transmission into the microcirculation. We, therefore, examined the effect of aortic-brachial stiffness mismatch on mortality in patients in need of dialysis. In a prospective observational study, aortic-brachial arterial stiffness mismatch (pulse wave velocity ratio) was assessed using carotid-femoral pulse wave velocity divided by carotid-radial pulse wave velocity in 310 adult patients on dialysis. After a median follow-up of 29 months, 146 (47%) deaths occurred. The hazard ratio (HR) for mortality related to PWV ratio in a Cox regression analysis was 1.43 (95% confidence interval [CI], 1.24-1.64; P<0.001 per 1 SD) and was still significant after adjustments for confounding factors, such as age, dialysis vintage, sex, cardiovascular disease, diabetes mellitus, smoking status, and weight (HR, 1.23; 95% CI: 1.02-1.49). The HRs for changes in 1 SD of augmentation index (HR, 1.35; 95% CI, 1.12-1.63), carotid-femoral pulse wave velocity (HR, 1.29; 95% CI, 1.11-1.50), and carotid-radial pulse wave velocity (HR, 0.80; 95% CI, 0.67-0.95) were statistically significant in univariate analysis, but were no longer statistically significant after adjustment for age. In conclusion, aortic-brachial arterial stiffness mismatch was strongly and independently associated with increased mortality in this dialysis population. Further studies are required to confirm these finding in lower-risk groups. |
| Author | Mac-Way, Fabrice Agharazii, Mohsen Marquis, Karine De Serres, Sacha A Desmeules, Simon Fortier, Catherine Lebel, Marcel Boutouyrie, Pierre |
| Author_xml | – sequence: 1 givenname: Catherine surname: Fortier fullname: Fortier, Catherine organization: From the CHU de Québec Research Center, L'Hôtel-Dieu de Québec Hospital, Québec, Québec, Canada (C.F., F.M., S.D., K.M., S.A.D.S., M.L., M.A.); Division of Nephrology, Faculty of Medicine, Université Laval, Québec, Québec, Canada (C.F., F.M., S.D., K.M., S.A.D.S., M.L., M.A.); Université Paris Descartes, Paris, France (P.B.); Department of Pharmacology, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France (P.B.); and Institut National de la Santé et de la Recherche Médicale, U970-PARCC, France (P.B.) – sequence: 2 givenname: Fabrice surname: Mac-Way fullname: Mac-Way, Fabrice organization: From the CHU de Québec Research Center, L'Hôtel-Dieu de Québec Hospital, Québec, Québec, Canada (C.F., F.M., S.D., K.M., S.A.D.S., M.L., M.A.); Division of Nephrology, Faculty of Medicine, Université Laval, Québec, Québec, Canada (C.F., F.M., S.D., K.M., S.A.D.S., M.L., M.A.); Université Paris Descartes, Paris, France (P.B.); Department of Pharmacology, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France (P.B.); and Institut National de la Santé et de la Recherche Médicale, U970-PARCC, France (P.B.) – sequence: 3 givenname: Simon surname: Desmeules fullname: Desmeules, Simon organization: From the CHU de Québec Research Center, L'Hôtel-Dieu de Québec Hospital, Québec, Québec, Canada (C.F., F.M., S.D., K.M., S.A.D.S., M.L., M.A.); Division of Nephrology, Faculty of Medicine, Université Laval, Québec, Québec, Canada (C.F., F.M., S.D., K.M., S.A.D.S., M.L., M.A.); Université Paris Descartes, Paris, France (P.B.); Department of Pharmacology, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France (P.B.); and Institut National de la Santé et de la Recherche Médicale, U970-PARCC, France (P.B.) – sequence: 4 givenname: Karine surname: Marquis fullname: Marquis, Karine organization: From the CHU de Québec Research Center, L'Hôtel-Dieu de Québec Hospital, Québec, Québec, Canada (C.F., F.M., S.D., K.M., S.A.D.S., M.L., M.A.); Division of Nephrology, Faculty of Medicine, Université Laval, Québec, Québec, Canada (C.F., F.M., S.D., K.M., S.A.D.S., M.L., M.A.); Université Paris Descartes, Paris, France (P.B.); Department of Pharmacology, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France (P.B.); and Institut National de la Santé et de la Recherche Médicale, U970-PARCC, France (P.B.) – sequence: 5 givenname: Sacha A surname: De Serres fullname: De Serres, Sacha A organization: From the CHU de Québec Research Center, L'Hôtel-Dieu de Québec Hospital, Québec, Québec, Canada (C.F., F.M., S.D., K.M., S.A.D.S., M.L., M.A.); Division of Nephrology, Faculty of Medicine, Université Laval, Québec, Québec, Canada (C.F., F.M., S.D., K.M., S.A.D.S., M.L., M.A.); Université Paris Descartes, Paris, France (P.B.); Department of Pharmacology, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France (P.B.); and Institut National de la Santé et de la Recherche Médicale, U970-PARCC, France (P.B.) – sequence: 6 givenname: Marcel surname: Lebel fullname: Lebel, Marcel organization: From the CHU de Québec Research Center, L'Hôtel-Dieu de Québec Hospital, Québec, Québec, Canada (C.F., F.M., S.D., K.M., S.A.D.S., M.L., M.A.); Division of Nephrology, Faculty of Medicine, Université Laval, Québec, Québec, Canada (C.F., F.M., S.D., K.M., S.A.D.S., M.L., M.A.); Université Paris Descartes, Paris, France (P.B.); Department of Pharmacology, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France (P.B.); and Institut National de la Santé et de la Recherche Médicale, U970-PARCC, France (P.B.) – sequence: 7 givenname: Pierre surname: Boutouyrie fullname: Boutouyrie, Pierre organization: From the CHU de Québec Research Center, L'Hôtel-Dieu de Québec Hospital, Québec, Québec, Canada (C.F., F.M., S.D., K.M., S.A.D.S., M.L., M.A.); Division of Nephrology, Faculty of Medicine, Université Laval, Québec, Québec, Canada (C.F., F.M., S.D., K.M., S.A.D.S., M.L., M.A.); Université Paris Descartes, Paris, France (P.B.); Department of Pharmacology, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France (P.B.); and Institut National de la Santé et de la Recherche Médicale, U970-PARCC, France (P.B.) – sequence: 8 givenname: Mohsen surname: Agharazii fullname: Agharazii, Mohsen email: Mohsen.Agharazii@crhdq.ulaval.ca organization: From the CHU de Québec Research Center, L'Hôtel-Dieu de Québec Hospital, Québec, Québec, Canada (C.F., F.M., S.D., K.M., S.A.D.S., M.L., M.A.); Division of Nephrology, Faculty of Medicine, Université Laval, Québec, Québec, Canada (C.F., F.M., S.D., K.M., S.A.D.S., M.L., M.A.); Université Paris Descartes, Paris, France (P.B.); Department of Pharmacology, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France (P.B.); and Institut National de la Santé et de la Recherche Médicale, U970-PARCC, France (P.B.). Mohsen.Agharazii@crhdq.ulaval.ca |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25452473$$D View this record in MEDLINE/PubMed |
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| Copyright | 2014 American Heart Association, Inc. |
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| Keywords | arterial stiffness dialysis chronic kidney disease aortic stiffness pulse wave velocity pulse wave analysis |
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| SubjectTerms | Age Factors Aged Brachial Artery Carotid Arteries Comorbidity Confounding Factors (Epidemiology) Diabetes Mellitus - epidemiology Female Femoral Artery Follow-Up Studies Humans Kaplan-Meier Estimate Kidney Failure, Chronic - mortality Kidney Failure, Chronic - physiopathology Kidney Failure, Chronic - therapy Male Middle Aged Overweight - epidemiology Peritoneal Dialysis Prognosis Proportional Hazards Models Prospective Studies Pulse Wave Analysis Radial Artery Renal Dialysis Vascular Stiffness |
| Title | Aortic-brachial stiffness mismatch and mortality in dialysis population |
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