Determination and stability of sex

How is the embryonic bipotential gonad regulated to produce either an ovary or a testis? In males, transient early activation of the Y chromosome Sry gene makes both germ cells and soma male. However, in females, available evidence suggests that the process of ovary sex determination may take place...

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Bibliographic Details
Published in:	BioEssays Vol. 29; no. 1; pp. 15 - 25
Main Authors:	Ottolenghi, Chris, Uda, Manuela, Crisponi, Laura, Omari, Shakib, Cao, Antonio, Forabosco, Antonino, Schlessinger, David
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.01.2007
Subjects:	Animals Disorders of Sex Development Female Forkhead Box Protein L2 Forkhead Transcription Factors - genetics Humans Male Mice Models, Genetic Ovary - embryology Proto-Oncogene Proteins - genetics Sex Determination Processes Sex Differentiation - genetics Testis - embryology Wnt Proteins - genetics Wnt4 Protein Y Chromosome - genetics
ISSN:	0265-9247, 1521-1878
Online Access:	Get full text
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