Reduced rDNA transcription diminishes skeletal muscle ribosomal capacity and protein synthesis in cancer cachexia

Muscle wasting in cancer is associated with deficits in protein synthesis, yet, the mechanisms underlying this anabolic impairment remain poorly understood. The capacity for protein synthesis is mainly determined by the abundance of muscle ribosomes, which is in turn regulated by transcription of th...

Full description

Saved in:

Bibliographic Details
Published in:	The FASEB journal Vol. 35; no. 2; p. e21335
Main Authors:	Kim, Hyo-Gun, Huot, Joshua R, Pin, Fabrizio, Guo, Bin, Bonetto, Andrea, Nader, Gustavo A
Format:	Journal Article
Language:	English
Published:	United States 01.02.2021
Subjects:	Animals Cachexia - etiology Cachexia - genetics Cachexia - metabolism Cell Line, Tumor DNA, Ribosomal - genetics DNA, Ribosomal - metabolism Female Mice Muscle, Skeletal - metabolism Ovarian Neoplasms - complications Protein Biosynthesis Ribosomes - metabolism RNA, Ribosomal - genetics RNA, Ribosomal - metabolism Transcription, Genetic RNA Polymerase 1 rDNA transcription anabolic deficit muscle wasting cancer cachexia ribosome biogenesis
ISSN:	1530-6860, 1530-6860
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!