IFT proteins interact with HSET to promote supernumerary centrosome clustering in mitosis

Centrosome amplification is a hallmark of cancer, and centrosome clustering is essential for cancer cell survival. The mitotic kinesin HSET is an essential contributor to this process. Recent studies have highlighted novel functions for intraflagellar transport (IFT) proteins in regulating motors an...

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Veröffentlicht in:	EMBO reports Jg. 21; H. 6; S. e49234 - n/a
Hauptverfasser:	Vitre, Benjamin, Taulet, Nicolas, Guesdon, Audrey, Douanier, Audrey, Dosdane, Aurelie, Cisneros, Melanie, Maurin, Justine, Hettinger, Sabrina, Anguille, Christelle, Taschner, Michael, Lorentzen, Esben, Delaval, Benedicte
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 04.06.2020 Springer Nature B.V EMBO Press John Wiley and Sons Inc
Schlagworte:	Amplification Cancer Carrier Proteins - genetics Cell proliferation Cell survival Centrosome - metabolism centrosome clustering Centrosomes Cluster Analysis Clustering Depletion EMBO05 EMBO06 HSET/KifC1 IFT proteins Kinesin Kinesin - genetics Kinesin - metabolism Life Sciences Microtubules Mitosis Mitosis - genetics Protein transport Proteins siRNA Spindles Supernumerary Survival Tumor cell lines cancer HSET/KifC1 mitosis centrosome clustering IFT proteins Cell Cycle mitosis Subject Categories Cell Adhesion Polarity & Cytoskeleton
ISSN:	1469-221X, 1469-3178, 1469-3178
Online-Zugang:	Volltext
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