Population pharmacokinetic modelling of repaglinide in healthy volunteers by using Non-Parametric Adaptive Grid Algorithm

Summary Objective: To estimate population pharmacokinetic parameters of repaglinide in 121 healthy Malaysian volunteers. Methods: Each subject received 4 mg of oral repaglinide. Six blood samples were taken per individual (0, 30, 60, 120, 180 and 240 min) for repaglinide’s serum concentration dete...

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Bibliographic Details
Published in:	Journal of clinical pharmacy and therapeutics Vol. 35; no. 1; pp. 105 - 112
Main Authors:	Ruzilawati, A. B., Mohd Suhaimi, A. W., Gan, S. H.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01.02.2010 Blackwell John Wiley & Sons, Inc
Subjects:	Adolescent Adult Algorithms Biological and medical sciences Body Mass Index Carbamates - blood Carbamates - pharmacokinetics Female Half-Life Humans Hypoglycemic Agents - blood Hypoglycemic Agents - pharmacokinetics it2b Male Medical sciences Metabolic Clearance Rate Middle Aged Models, Biological npag Pharmacology. Drug treatments Piperidines - blood Piperidines - pharmacokinetics population pharmacokinetic modelling repaglinide Young Adult Human Population pharmacokinetics Hypoglycemic agent Meglitinide derivatives Healthy subject Repaglinide IT2B NPAG Algorithm population pharmacokinetic modelling
ISSN:	0269-4727, 1365-2710, 1365-2710
Online Access:	Get full text
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