Population pharmacokinetic modelling of repaglinide in healthy volunteers by using Non-Parametric Adaptive Grid Algorithm

Summary Objective:  To estimate population pharmacokinetic parameters of repaglinide in 121 healthy Malaysian volunteers. Methods:  Each subject received 4 mg of oral repaglinide. Six blood samples were taken per individual (0, 30, 60, 120, 180 and 240 min) for repaglinide’s serum concentration dete...

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Veröffentlicht in:Journal of clinical pharmacy and therapeutics Jg. 35; H. 1; S. 105 - 112
Hauptverfasser: Ruzilawati, A. B., Mohd Suhaimi, A. W., Gan, S. H.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Oxford, UK Blackwell Publishing Ltd 01.02.2010
Blackwell
John Wiley & Sons, Inc
Schlagworte:
Adolescent
Adult
Algorithms
Biological and medical sciences
Body Mass Index
Carbamates - blood
Carbamates - pharmacokinetics
Female
Half-Life
Humans
Hypoglycemic Agents - blood
Hypoglycemic Agents - pharmacokinetics
it2b
Male
Medical sciences
Metabolic Clearance Rate
Middle Aged
Models, Biological
npag
Pharmacology. Drug treatments
Piperidines - blood
Piperidines - pharmacokinetics
population pharmacokinetic modelling
repaglinide
Young Adult
Human
Population pharmacokinetics
Hypoglycemic agent
Meglitinide derivatives
Healthy subject
Repaglinide
IT2B
NPAG
Algorithm
population pharmacokinetic modelling
ISSN:0269-4727, 1365-2710, 1365-2710
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Zusammenfassung:Summary Objective:  To estimate population pharmacokinetic parameters of repaglinide in 121 healthy Malaysian volunteers. Methods:  Each subject received 4 mg of oral repaglinide. Six blood samples were taken per individual (0, 30, 60, 120, 180 and 240 min) for repaglinide’s serum concentration determination by using high‐performance liquid chromatography. The parametric Iterative Two‐Stage Bayesian Population Model (it2b) program followed by the Non‐Parametric Adaptive Grid (npag) program was used to determine a population pharmacokinetic modelling of repaglinide. Results:  Using the npag program, the mean elimination rate constant (kel) of repaglinide was 0·58 ± 0·27 h and the volume of distribution (Vd) was 23·09 ± 9·19 L/h. Conclusion:  In this first report, specifically on the population pharmacokinetic modelling of repaglinide, the data generated should help us to better understand appropriate dosage‐regimens for the drug.
Bibliographie:ark:/67375/WNG-VVH6HX7C-T
istex:F101BD067E30A9FE31A497B87E8EB18E4FD8AB56
ArticleID:JCPT1042
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:0269-4727
1365-2710
1365-2710
DOI:10.1111/j.1365-2710.2009.01042.x