Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis

: In sepsis, quiescent blood vessels become leaky and inflamed by mechanisms that are incompletely understood. We hypothesized that angiopoietin-2, a partial antagonist of the endothelium-stabilizing receptor Tie-2 secreted by endothelium, contributes to adverse outcomes in this disease. : Laborator...

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Bibliographic Details
Published in:	Critical care medicine Vol. 40; no. 11; p. 3034
Main Authors:	David, Sascha, Mukherjee, Aditi, Ghosh, Chandra C, Yano, Midori, Khankin, Eliyahu V, Wenger, Julia B, Karumanchi, S Ananth, Shapiro, Nathan I, Parikh, Samir M
Format:	Journal Article
Language:	English
Published:	United States 01.11.2012
Subjects:	Adult Aged Aged, 80 and over Angiopoietin-2 - genetics Angiopoietin-2 - immunology Angiopoietin-2 - physiology Animals Female Heterozygote Humans Male Mice Mice, 129 Strain Mice, Inbred C57BL Middle Aged Multiple Organ Failure - mortality Multiple Organ Failure - physiopathology Sepsis - mortality Sepsis - physiopathology Survival Analysis
ISSN:	1530-0293, 1530-0293
Online Access:	Get more information
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