Statistical inference of the generation probability of T-cell receptors from sequence repertoires

Stochastic rearrangement of germline V-, D-, and J-genes to create variable coding sequence for certain cell surface receptors is at the origin of immune system diversity. This process, known as "VDJ recombination", is implemented via a series of stochastic molecular events involving gene...

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Bibliographic Details

Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 109; no. 40; p. 16161
Main Authors:	Murugan, Anand, Mora, Thierry, Walczak, Aleksandra M, Callan, Jr, Curtis G
Format:	Journal Article
Language:	English
Published:	United States 02.10.2012
Subjects:	Adaptive Immunity - genetics Algorithms Antibody Diversity - genetics Base Sequence CD4-Positive T-Lymphocytes - metabolism Computational Biology - methods Genes, T-Cell Receptor beta - genetics Humans Likelihood Functions Models, Biological Molecular Sequence Data Sequence Alignment Sequence Analysis, DNA V(D)J Recombination - genetics
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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