Assessment of normal myelination in infants and young children using the T1w/T2w mapping technique

White matter myelination is a crucial process of CNS maturation. The purpose of this study was to validate the T1w/T2w mapping technique for brain myelination assessment in infants and young children. Ninety-four patients (0-23 months of age) without structural abnormalities on brain MRI were evalua...

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Published in:Frontiers in neuroscience Vol. 17; p. 1102691
Main Authors: Filimonova, Elena, Amelina, Evgenia, Sazonova, Aleksandra, Zaitsev, Boris, Rzaev, Jamil
Format: Journal Article
Language:English
Published: Switzerland Frontiers Research Foundation 28.02.2023
Frontiers Media S.A
Subjects:
Age
Brain mapping
Children
Corpus callosum
Correlation analysis
General anesthesia
Infants
Magnetic resonance imaging
Medical imaging
Myelination
Neuroimaging
Neuroscience
Pathology
Patients
Pediatrics
Regression analysis
Software
Substantia alba
T1w/T2w mapping
myelination
T1w/T2w mapping
magnetic resonance imaging
infants
children
ISSN:1662-453X, 1662-4548, 1662-453X
Online Access:Get full text
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Summary:White matter myelination is a crucial process of CNS maturation. The purpose of this study was to validate the T1w/T2w mapping technique for brain myelination assessment in infants and young children. Ninety-four patients (0-23 months of age) without structural abnormalities on brain MRI were evaluated by using the T1w/T2w mapping method. The T1w/T2w signal intensity ratio, which reflects white matter integrity and the degree of myelination, was calculated in various brain regions. We performed a Pearson correlation analysis, a LOESS regression analysis, and a 2 order polynomial regression analysis to describe the relationships between the regional metrics and the age of the patients (in months). T1w/T2w ratio values rapidly increased in the first 6-9 months of life and then slowed thereafter. The T1w/T2w mapping technique emphasized the contrast between myelinated and less myelinated structures in all age groups, which resulted in better visualization. There were strong positive correlations between the T1w/T2w ratio values from the majority of white matter ROIs and the subjects' age ( = 0.7-0.9, < 0.001). Within all of the analyzed regions, there were non-linear relationships between age and T1/T2 ratio values that varied by anatomical and functional location. Regions such as the splenium and the genu of the corpus callosum showed the highest R values, thus indicating less scattering of data and a better fit to the model. The T1w/T2w mapping technique may enhance our diagnostic ability to assess myelination patterns in the brains of infants and young children.
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This article was submitted to Neurodevelopment, a section of the journal Frontiers in Neuroscience
Reviewed by: Anna Tietze, Charité – Universitätsmedizin Berlin, Germany; Youyi Liu, Beijing Normal University, China
Edited by: Zonglei Zhen, Beijing Normal University, China
ISSN:1662-453X
1662-4548
1662-453X
DOI:10.3389/fnins.2023.1102691