Cognitive impairment, all-cause and cause-specific mortality among non-demented older adults
cognitive impairment is widespread among older adults even in the absence of dementia, but very little is known about the association between cognitive impairment not due or not yet converted to dementia and mortality. The association between cognitive impairment and mortality contributes to assessi...
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| Published in: | Age and ageing Vol. 44; no. 3; p. 445 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
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01.05.2015
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| ISSN: | 1468-2834, 1468-2834 |
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| Abstract | cognitive impairment is widespread among older adults even in the absence of dementia, but very little is known about the association between cognitive impairment not due or not yet converted to dementia and mortality. The association between cognitive impairment and mortality contributes to assessing cognitive impairment-related risk constellation in old age in the absence of manifest dementia.
to assess the impact of cognitive impairment on all-cause and cause-specific mortality among non-demented older adults and to explore the nature of the association between cognitive impairment and mortality.
an observational cohort study (ESTHER study; 2000-present).
German state of Saarland.
a subsample of 1,622 participants aged ≥70 with measurement of cognitive function through the Cognitive Telephone Screening Instrument (COGTEL) and exclusion of a possible dementia diagnosis at both COGTEL baseline (2005-08) and over the mortality follow-up (2005-13).
during an average follow-up of 6.1 years, 231 participants (14.2%) died. Participants with low COGTEL total scores had ∼60% increased mortality compared with participants with higher COGTEL total scores in Cox regression models adjusting for a wide range of possible confounders (hazard ratio = 1.62; confidence interval 1.13-2.33). Dose-response analyses with restricted cubic splines indicate a monotonic inverse relationship between cognitive function and mortality.
cognitive impairment in the absence of manifest dementia is an important independent predictor of mortality, especially among men. The administration of cognitive tests among older adults may provide relevant information for patient care and treatment decisions.
financial sponsors played no role in the design, execution, analysis and interpretation of data. |
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| AbstractList | cognitive impairment is widespread among older adults even in the absence of dementia, but very little is known about the association between cognitive impairment not due or not yet converted to dementia and mortality. The association between cognitive impairment and mortality contributes to assessing cognitive impairment-related risk constellation in old age in the absence of manifest dementia.BACKGROUNDcognitive impairment is widespread among older adults even in the absence of dementia, but very little is known about the association between cognitive impairment not due or not yet converted to dementia and mortality. The association between cognitive impairment and mortality contributes to assessing cognitive impairment-related risk constellation in old age in the absence of manifest dementia.to assess the impact of cognitive impairment on all-cause and cause-specific mortality among non-demented older adults and to explore the nature of the association between cognitive impairment and mortality.OBJECTIVEto assess the impact of cognitive impairment on all-cause and cause-specific mortality among non-demented older adults and to explore the nature of the association between cognitive impairment and mortality.an observational cohort study (ESTHER study; 2000-present).DESIGNan observational cohort study (ESTHER study; 2000-present).German state of Saarland.SETTINGGerman state of Saarland.a subsample of 1,622 participants aged ≥70 with measurement of cognitive function through the Cognitive Telephone Screening Instrument (COGTEL) and exclusion of a possible dementia diagnosis at both COGTEL baseline (2005-08) and over the mortality follow-up (2005-13).SUBJECTSa subsample of 1,622 participants aged ≥70 with measurement of cognitive function through the Cognitive Telephone Screening Instrument (COGTEL) and exclusion of a possible dementia diagnosis at both COGTEL baseline (2005-08) and over the mortality follow-up (2005-13).during an average follow-up of 6.1 years, 231 participants (14.2%) died. Participants with low COGTEL total scores had ∼60% increased mortality compared with participants with higher COGTEL total scores in Cox regression models adjusting for a wide range of possible confounders (hazard ratio = 1.62; confidence interval 1.13-2.33). Dose-response analyses with restricted cubic splines indicate a monotonic inverse relationship between cognitive function and mortality.RESULTSduring an average follow-up of 6.1 years, 231 participants (14.2%) died. Participants with low COGTEL total scores had ∼60% increased mortality compared with participants with higher COGTEL total scores in Cox regression models adjusting for a wide range of possible confounders (hazard ratio = 1.62; confidence interval 1.13-2.33). Dose-response analyses with restricted cubic splines indicate a monotonic inverse relationship between cognitive function and mortality.cognitive impairment in the absence of manifest dementia is an important independent predictor of mortality, especially among men. The administration of cognitive tests among older adults may provide relevant information for patient care and treatment decisions.CONCLUSIONcognitive impairment in the absence of manifest dementia is an important independent predictor of mortality, especially among men. The administration of cognitive tests among older adults may provide relevant information for patient care and treatment decisions.financial sponsors played no role in the design, execution, analysis and interpretation of data.SOURCES OF FUNDINGfinancial sponsors played no role in the design, execution, analysis and interpretation of data. cognitive impairment is widespread among older adults even in the absence of dementia, but very little is known about the association between cognitive impairment not due or not yet converted to dementia and mortality. The association between cognitive impairment and mortality contributes to assessing cognitive impairment-related risk constellation in old age in the absence of manifest dementia. to assess the impact of cognitive impairment on all-cause and cause-specific mortality among non-demented older adults and to explore the nature of the association between cognitive impairment and mortality. an observational cohort study (ESTHER study; 2000-present). German state of Saarland. a subsample of 1,622 participants aged ≥70 with measurement of cognitive function through the Cognitive Telephone Screening Instrument (COGTEL) and exclusion of a possible dementia diagnosis at both COGTEL baseline (2005-08) and over the mortality follow-up (2005-13). during an average follow-up of 6.1 years, 231 participants (14.2%) died. Participants with low COGTEL total scores had ∼60% increased mortality compared with participants with higher COGTEL total scores in Cox regression models adjusting for a wide range of possible confounders (hazard ratio = 1.62; confidence interval 1.13-2.33). Dose-response analyses with restricted cubic splines indicate a monotonic inverse relationship between cognitive function and mortality. cognitive impairment in the absence of manifest dementia is an important independent predictor of mortality, especially among men. The administration of cognitive tests among older adults may provide relevant information for patient care and treatment decisions. financial sponsors played no role in the design, execution, analysis and interpretation of data. |
| Author | Wahl, Hans-Werner Saum, Kai-Uwe Holleczek, Bernd Mons, Ute Perna, Laura Brenner, Hermann |
| Author_xml | – sequence: 1 givenname: Laura surname: Perna fullname: Perna, Laura organization: German Cancer Research Center (DKFZ) - Division of Clinical Epidemiology and Aging Research, Im Neuenheimer Feld 581-69120 Heidelberg, Germany – sequence: 2 givenname: Hans-Werner surname: Wahl fullname: Wahl, Hans-Werner organization: Department of Psychological Aging Research, Institute of Psychology, Heidelberg University, Hauptstrasse 47-51-69117 Heidelberg, Germany – sequence: 3 givenname: Ute surname: Mons fullname: Mons, Ute organization: German Cancer Research Center (DKFZ) - Division of Clinical Epidemiology and Aging Research, Im Neuenheimer Feld 581-69120 Heidelberg, Germany – sequence: 4 givenname: Kai-Uwe surname: Saum fullname: Saum, Kai-Uwe organization: German Cancer Research Center (DKFZ) - Division of Clinical Epidemiology and Aging Research, Im Neuenheimer Feld 581-69120 Heidelberg, Germany – sequence: 5 givenname: Bernd surname: Holleczek fullname: Holleczek, Bernd organization: Saarland Cancer Registry, Präsident Baltz Straβe 5-66119 Saarbrücken, Germany – sequence: 6 givenname: Hermann surname: Brenner fullname: Brenner, Hermann organization: German Cancer Research Center (DKFZ) - Division of Clinical Epidemiology and Aging Research, Im Neuenheimer Feld 581-69120 Heidelberg, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25468013$$D View this record in MEDLINE/PubMed |
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| Title | Cognitive impairment, all-cause and cause-specific mortality among non-demented older adults |
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