Bryostatin-1 enhances the proliferation and functionality of exhausted CD8+ T cells by upregulating MAP Kinase 11

Bryostatin-1, a potent agonist of the protein kinase C, has been studied for HIV and cancer therapies. In HIV research, it has shown anti-HIV effects during acute infection and reactivation of latent HIV in chronic infection. As effective CD8+ T cell responses are essential for eliminating reactivat...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 15; p. 1509874
Main Authors:	Li, Ling, Zhao, Manzhi, van Meurs, Marjan, Brouwers-Haspels, Inge, den Dekker, Renske J. H., Wilmsen, Merel E. P., Grashof, Dwin G. B., van de Werken, Harmen J. G., Rao, Shringar, Rokx, Casper, Mueller, Yvonne M., Katsikis, Peter D.
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media SA 14.01.2025 Frontiers Media S.A
Subjects:	Animals bryostatin-1 Bryostatins - pharmacology Cancer Cancer immunotherapy Cancer therapies CD8 antigen CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell growth Cell proliferation Cell Proliferation - drug effects Chronic infection Clinical trials Cytotoxicity Down-regulation exhausted CD8+ T cells Flow cytometry Hepatocyte nuclear factor 1 HIV HIV Infections - drug therapy HIV Infections - immunology HIV-1 - immunology Human immunodeficiency virus Humans IFN-γ production Immunity (Disease) Immunology Infections Kinases Lymphocyte Activation - drug effects Lymphocytes Lymphocytes T MAP kinase MAP kinase 11 Mice PD-1 protein Peptides Protein kinase C Proteins Ribonucleic acid RNA Sequence analysis Transcription factors Up-Regulation γ-Interferon HIV bryostatin-1 IFN-γ production exhausted CD8+ T cells MAP kinase 11
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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