Immunomodulatory effects of cysteamine and its potential use as a host-directed therapy for tuberculosis

Cysteamine, a drug approved to treat cystinosis, has been proposed as a host-directed therapy for (Mtb) and SARS-CoV-2. The impact of cysteamine on the immune responses has not been fully investigated. We aimed to evaluate the immunomodulatory effects of cysteamine on peripheral blood mononuclear ce...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 15; p. 1411827
Main Authors:	Najafi-Fard, Saeid, Farroni, Chiara, Petrone, Linda, Altera, Anna Maria Gerarda, Salmi, Andrea, Vanini, Valentina, Cuzzi, Gilda, Alonzi, Tonino, Nicastri, Emanuele, Gualano, Gina, Palmieri, Fabrizio, Piacentini, Mauro, Goletti, Delia
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media SA 28.10.2024 Frontiers Media S.A
Subjects:	Adult Ag-specific response Apoptosis Apoptosis - drug effects Autophagy Cell death Cell viability COVID-19 COVID-19 - immunology COVID-19 vaccines cysteamine Cysteamine - pharmacology Cysteamine - therapeutic use Cystinosis Cytokines Cytokines - metabolism Drug resistance Enterotoxins Female Flow cytometry Granulomas HIV Homeostasis host-directed therapy Human immunodeficiency virus Humans Immune response Immunology Immunomodulating Agents - pharmacology Immunomodulating Agents - therapeutic use Immunomodulation Infectious diseases Inflammation Leukocytes (mononuclear) Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Life sciences Lungs Lymphocytes T Male Middle Aged Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - immunology Necrosis Pathogens Peripheral blood mononuclear cells PPD-specific response SARS-CoV-2 - immunology Severe acute respiratory syndrome coronavirus 2 Staphylococcal enterotoxin B Th1 Cells - drug effects Th1 Cells - immunology Tuberculin Tuberculin - immunology Tuberculosis Tuberculosis - drug therapy Tuberculosis - immunology Tumor necrosis factor-TNF Viral infections United States > US Italy Ag-specific response inflammation necrosis tuberculosis apoptosis cysteamine host-directed therapy PPD-specific response
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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