Human immunodeficiency virus reverse transcriptase. Substrate and inhibitor kinetics with thymidine 5'-triphosphate and 3'-azido-3'-deoxythymidine 5'-triphosphate

3'-Azido-3'-deoxythymidine 5'-triphosphate (AZTTP) was an efficient substrate for the human immunodeficiency virus 1 reverse transcriptase. It was incorporated into both homopolymer and defined sequence DNA-primed RNA templates and DNA-primed DNA templates. The substrate and inhibitor...

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Vydáno v:	The Journal of biological chemistry Ročník 265; číslo 33; s. 20302
Hlavní autoři:	Reardon, J E, Miller, W H
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 25.11.1990
Témata:	Antiviral Agents - metabolism Base Sequence Dideoxynucleotides DNA, Viral - genetics HIV-1 - enzymology Kinetics Molecular Sequence Data Plasmids Protein Binding Recombinant Proteins - antagonists & inhibitors Recombinant Proteins - metabolism Restriction Mapping Reverse Transcriptase Inhibitors RNA, Viral - genetics RNA-Directed DNA Polymerase - metabolism Templates, Genetic Thymine Nucleotides - metabolism Thymine Nucleotides - pharmacology Tritium Zidovudine - analogs & derivatives Zidovudine - metabolism Zidovudine - pharmacology
ISSN:	0021-9258
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