Location matters: spatial dynamics of tumor-infiltrating T cell subsets is prognostic in colon cancer

Colon cancer is a heterogeneous disease and consists of various molecular subtypes. Despite advances in high-throughput expression profiling, limitations remain in predicting clinical outcome and assigning specific treatment to individual cases. Tumor-immune interactions play a critical role, with t...

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Veröffentlicht in:	Frontiers in immunology Jg. 15; S. 1293618
Hauptverfasser:	Zhu, Hehuan, Roelands, Jessica, Ahmed, Eiman I., Stouten, Imke, Hoorntje, Rachel, van Vlierberghe, Ronald L. P., Ijsselsteijn, Marieke E., Lei, Xin, de Miranda, Noel F. C. C., Tollenaar, Rob A. E. M., Vahrmeijer, Alexander L., Bedognetti, Davide, Hendrickx, Wouter R. L., Kuppen, Peter J. K.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland Frontiers Media SA 05.02.2024 Frontiers Media S.A
Schlagworte:	Adjuvants Antibodies Antigens Biomarkers CD3 antigen CD8 antigen CD8-Positive T-Lymphocytes Cell density Cell number Cell survival Chemotherapy Clinical outcomes Colon cancer Colonic Neoplasms - pathology Colorectal cancer Cytotoxicity DNA sequencing Epithelium Forkhead Transcription Factors - analysis Foxp3 protein Gene expression Granzyme B Humans Immune system Immunofluorescence Immunohistochemistry immunologic constant of rejection Immunology Immunotherapy Localization Lymphocytes Lymphocytes T multiplex immunofluorescence Patients Phenotypes Prognosis Software packages spatial analysis Spatial distribution Statistical analysis T cell T cell receptors T-Lymphocyte Subsets Transcriptomes Tumor cells Tumor Microenvironment Tumors Netherlands immunologic constant of rejection spatial analysis tumor microenvironment T cell colon cancer multiplex immunofluorescence
ISSN:	1664-3224, 1664-3224
Online-Zugang:	Volltext
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