Broad anti-SARS-CoV-2 antibody immunity induced by heterologous ChAdOx1/mRNA-1273 vaccination

Heterologous prime-boost immunization strategies have the potential to augment COVID-19 vaccine efficacy. We longitudinally profiled severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S)-specific serological and memory B cell (MBC) responses in individuals who received either homolo...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) Jg. 375; H. 6584; S. 1041
Hauptverfasser:	Kaku, Chengzi I, Champney, Elizabeth R, Normark, Johan, Garcia, Marina, Johnson, Carl E, Ahlm, Clas, Christ, Wanda, Sakharkar, Mrunal, Ackerman, Margaret E, Klingström, Jonas, Forsell, Mattias N E, Walker, Laura M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 04.03.2022
Schlagworte:	2019-nCoV Vaccine mRNA-1273 - administration & dosage 2019-nCoV Vaccine mRNA-1273 - immunology Adult Antibodies, Monoclonal - immunology Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibodies, Viral - blood Antibodies, Viral - immunology Antibody Specificity ChAdOx1 nCoV-19 - administration & dosage ChAdOx1 nCoV-19 - immunology COVID-19 Vaccines - immunology Female Humans Immunization Schedule Immunization, Secondary Immunogenicity, Vaccine Male Memory B Cells - immunology Middle Aged Protein Conformation Protein Domains SARS-CoV-2 - immunology Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - immunology
ISSN:	1095-9203, 1095-9203
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