Stress-triggered hematopoietic stem cell proliferation relies on PrimPol-mediated repriming

Stem cell division is linked to tumorigenesis by yet-elusive mechanisms. The hematopoietic system reacts to stress by triggering hematopoietic stem and progenitor cell (HSPC) proliferation, which can be accompanied by chromosomal breakage in activated hematopoietic stem cells (HSCs). However, whethe...

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Vydané v:	Molecular cell Ročník 82; číslo 21; s. 4176
Hlavní autori:	Jacobs, Kurt, Doerdelmann, Cyril, Krietsch, Jana, González-Acosta, Daniel, Mathis, Nicolas, Kushinsky, Saul, Guarino, Estrella, Gómez-Escolar, Carmen, Martinez, Dolores, Schmid, Jonas A, Leary, Peter J, Freire, Raimundo, Ramiro, Almudena R, Eischen, Christine M, Mendez, Juan, Lopes, Massimo
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 03.11.2022
Predmet:	Animals Cell Proliferation DNA Damage DNA Replication Hematopoiesis - genetics Hematopoietic Stem Cells - physiology Mice DNA replication Primpol stem cell division repriming DNA damage response bone marrow reconstitution hematopoietic stem cells replication fork plasticity induced proliferation
ISSN:	1097-4164, 1097-4164
On-line prístup:	Zistit podrobnosti o prístupe
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