Stress-triggered hematopoietic stem cell proliferation relies on PrimPol-mediated repriming

Stem cell division is linked to tumorigenesis by yet-elusive mechanisms. The hematopoietic system reacts to stress by triggering hematopoietic stem and progenitor cell (HSPC) proliferation, which can be accompanied by chromosomal breakage in activated hematopoietic stem cells (HSCs). However, whethe...

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Veröffentlicht in:	Molecular cell Jg. 82; H. 21; S. 4176
Hauptverfasser:	Jacobs, Kurt, Doerdelmann, Cyril, Krietsch, Jana, González-Acosta, Daniel, Mathis, Nicolas, Kushinsky, Saul, Guarino, Estrella, Gómez-Escolar, Carmen, Martinez, Dolores, Schmid, Jonas A, Leary, Peter J, Freire, Raimundo, Ramiro, Almudena R, Eischen, Christine M, Mendez, Juan, Lopes, Massimo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 03.11.2022
Schlagworte:	Animals Cell Proliferation DNA Damage DNA Replication Hematopoiesis - genetics Hematopoietic Stem Cells - physiology Mice DNA replication Primpol stem cell division repriming DNA damage response bone marrow reconstitution hematopoietic stem cells replication fork plasticity induced proliferation
ISSN:	1097-4164, 1097-4164
Online-Zugang:	Weitere Angaben
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