Cognitive reserve and the risk of postoperative neurocognitive disorders in older age

Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are postoperative neurocognitive disorders (PNDs) that frequently occur in the aftermath of a surgical intervention. Cognitive reserve (CR) is a concept posited to explain why cognitive health varies between individuals. On...

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Vydané v:Frontiers in aging neuroscience Ročník 15; s. 1327388
Hlavní autori: Borchers, Friedrich, Rumpel, Miriam, Laubrock, Jochen, Spies, Claudia, Kozma, Petra, Slooter, Arjen, van Montfort, Simone J. T., Piper, Sophie K., Wiebach, Janine, Winterer, Georg, Pischon, Tobias, Feinkohl, Insa
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland Frontiers Research Foundation 05.02.2024
Frontiers Media S.A
Predmet:
Abdominal surgery
Aging Neuroscience
Anesthesia
Biomarkers
Bone surgery
Brain research
Classification
Cognition
Cognitive ability
cognitive reserve
Comorbidity
Education
elective surgery
geriatric assessment
Geriatrics
Intelligence
Mental depression
Patients
postoperative cognitive dysfunction
postoperative delirium
postoperative neurocognitive disorders
Regression analysis
Risk factors
Surgery
postoperative neurocognitive disorders
elective surgery
geriatric assessment
postoperative cognitive dysfunction
postoperative delirium
cognitive reserve
ISSN:1663-4365, 1663-4365
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Shrnutí:Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are postoperative neurocognitive disorders (PNDs) that frequently occur in the aftermath of a surgical intervention. Cognitive reserve (CR) is a concept posited to explain why cognitive health varies between individuals. On this qualitative understanding of cognitive health, factors like IQ, education level, and occupational complexity can affect the impact of neuropathological processes on cognitive outcomes. We investigated the association between CR and POD and CR and POCD on data from 713 patients aged≥65 years with elective surgery. Peak pre-morbid IQ was estimated from vocabulary. Occupational complexity was coded according to the Dictionary of Occupational Titles (DOT). Education level was classed according to the International Standard Classification of Education (ISCED). These three factors were used as proxies of CR. In a series of regression models, age, sex, depression, site of surgery, and several lifestyle and vascular factors were controlled for. Patients with a higher IQ had lower odds of developing POD. We found no significant association between the other two CR markers with POD. None of the CR markers was associated with POCD. The significant association of a higher IQ with lower POD risk allows for the stratification of elderly surgical patients by risk. This knowledge can aid the prevention and/or early detection of POD. Further research should attempt to determine the lack of associations of CR markers with POCD in our study.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Jared Tanner, University of Florida, United States
Edited by: Haiqing Huang, University of Pittsburgh, United States
Reviewed by: Margaret Ellenora Wiggins, UC San Diego Health, University of California, San Diego, United States
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2023.1327388