NLRC5 overexpression in ovarian tumors remodels the tumor microenvironment and increases T-cell reactivity toward autologous tumor-associated antigens

Epithelial ovarian cancer (OC) stands as one of the deadliest gynecologic malignancies, urgently necessitating novel therapeutic strategies. Approximately 60% of ovarian tumors exhibit reduced expression of major histocompatibility complex class I (MHC I), intensifying immune evasion mechanisms and...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 14; p. 1295208
Main Authors:	Rodriguez, Galaxia M., Yakubovich, Edward, Murshed, Humaira, Maranda, Vincent, Galpin, Kristianne J.C., Cudmore, Alison, Hanna, Andrew M. R., Macdonald, Elizabeth, Ramesh, Shashankan, Garson, Kenneth, Vanderhyden, Barbara C.
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media SA 03.01.2024 Frontiers Media S.A
Subjects:	Animals Antigen (tumor-associated) Antigen presentation Antigens Antigens, Neoplasm Ascites Cancer therapies Caspase Activation and Recruitment Domain CD4 antigen CD8 antigen Cell activation Cell culture Cell cycle Cell recognition Correlation analysis Female Gene expression Histocompatibility Antigens Class I Humans Immunology Immunotherapy infected cell vaccine Intracellular Signaling Peptides and Proteins - metabolism Leukocyte migration Lymphocytes Lymphocytes T Major histocompatibility complex Malignancy Medical prognosis Metadata MHC I Mice NLR Proteins NLRC5 Ovarian cancer Ovarian Neoplasms - genetics Patients PD-L1 protein Peripheral blood Survival analysis tumor immunogenicity Tumor Microenvironment Tumors Vaccines γ-Interferon NLRC5 infected cell vaccine tumor immunogenicity tumor microenvironment ovarian cancer MHC I
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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