Specific immune response to M. tuberculosis and ability to in vitro control mycobacterial replication are not impaired in subjects with immune-mediated inflammatory disease and tuberculosis infection

Subjects with immune-mediated inflammatory diseases (IMID), such as rheumatoid arthritis, with tuberculosis infection (TBI), have a high probability of progressing to tuberculosis disease (TB). We aim to characterize the impact of IMID on the immune response to (Mtb) in patients with TBI and TB dise...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 15; p. 1484143
Main Authors:	Farroni, Chiara, Altera, Anna Maria Gerarda, Salmi, Andrea, Vanini, Valentina, Cuzzi, Gilda, Lindestam Arlehamn, Cecilia S., Sette, Alessandro, Delogu, Giovanni, Palucci, Ivana, Sbarra, Settimia, Aiello, Alessandra, Picchianti-Diamanti, Andrea, Gualano, Gina, Palmieri, Fabrizio, Goletti, Delia, Petruccioli, Elisa
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media SA 13.01.2025 Frontiers Media S.A
Subjects:	Adult AIM assay, IFN-γ antigen-specific response Antigens Arthritis, Rheumatoid - immunology CD134 antigen CD25 antigen CD27 antigen CD4 antigen CD4-Positive T-Lymphocytes - immunology CD45RA antigen Cell activation Cytokines Cytokines - metabolism Disease prevention Drugs Epitopes Female Histocompatibility antigen HLA Humans Immune response Immune system Immunity (Disease) Immunologic Memory Immunological memory Immunology Infections Inflammatory diseases Leukocytes (mononuclear) Lymphocyte Activation Lymphocytes Lymphocytes T Male Memory cells MGIA Middle Aged Mycobacterium tuberculosis - growth & development Mycobacterium tuberculosis - immunology Patients Peripheral blood mononuclear cells Phenotypes Population Replication Rheumatoid arthritis Steroids Th1 Tuberculosis Tuberculosis - immunology Tuberculosis - microbiology Vaccines γ-Interferon Europe tuberculosis infection MGIA tuberculosis Th1 rheumatoid arthritis antigen-specific response AIM assay, IFN-γ
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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