Roles of interferon and cellular adhesion molecules in bacterial activation of human natural killer cells

Interaction of lipopolysaccharide (LPS) from enteric and oral bacteria with natural killer (NK) cells enhanced cytotoxicity against NK-sensitive and NK-resistant targets. This activation occurred without expansion of the NK cell population or without changes in the leukocyte function-associated anti...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Infection and immunity Ročník 57; číslo 6; s. 1702
Hlavný autor: Lindemann, R A
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 01.06.1989
Predmet:
Antibodies, Monoclonal - physiology
Antigens, Bacterial - immunology
Antigens, Surface - analysis
Antigens, Surface - immunology
Binding Sites, Antibody
Binding, Competitive
Cell Adhesion Molecules
Cytotoxicity, Immunologic
Humans
Immune Sera - pharmacology
Interferon Inducers - immunology
Interferons - biosynthesis
Interferons - immunology
Interferons - physiology
Killer Cells, Natural - immunology
Killer Cells, Natural - metabolism
Killer Cells, Natural - microbiology
Lipopolysaccharides - immunology
Lymphocyte Activation
Receptors, Immunologic - analysis
ISSN:0019-9567
On-line prístup:Zistit podrobnosti o prístupe
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Abstract Interaction of lipopolysaccharide (LPS) from enteric and oral bacteria with natural killer (NK) cells enhanced cytotoxicity against NK-sensitive and NK-resistant targets. This activation occurred without expansion of the NK cell population or without changes in the leukocyte function-associated antigen family of cellular adhesion molecule (CAM) expression on NK cells. Significant interferon (IFN) titers were measured in LPS-lymphocyte supernatants, and antibody to IFN-alpha blocked LPS activation. LPS-induced NK cytotoxicity was inhibited by antibodies to individual alpha chains of CAM and, more profoundly, by antibody to the beta chain of CAM. However, LPS, when preincubated with NK cells, did not compete with subsequent anti-CAM antibody binding as detected by flow cytometry. Anti-CAM antibodies had no effect on NK activation by IFN, but antibodies to either CD11a or CD11c abrogated IFN production induced by LPS. These findings suggest that LPS binds NK cells at non-CAM sites, resulting in the release of IFN. IFN then acts in an autocrine manner independent of CAM to enhance NK cytotoxicity. Interaction of anti-CAM antibodies with CAM may provide a negative signal in regulating LPS-induced IFN production.
AbstractList Interaction of lipopolysaccharide (LPS) from enteric and oral bacteria with natural killer (NK) cells enhanced cytotoxicity against NK-sensitive and NK-resistant targets. This activation occurred without expansion of the NK cell population or without changes in the leukocyte function-associated antigen family of cellular adhesion molecule (CAM) expression on NK cells. Significant interferon (IFN) titers were measured in LPS-lymphocyte supernatants, and antibody to IFN-alpha blocked LPS activation. LPS-induced NK cytotoxicity was inhibited by antibodies to individual alpha chains of CAM and, more profoundly, by antibody to the beta chain of CAM. However, LPS, when preincubated with NK cells, did not compete with subsequent anti-CAM antibody binding as detected by flow cytometry. Anti-CAM antibodies had no effect on NK activation by IFN, but antibodies to either CD11a or CD11c abrogated IFN production induced by LPS. These findings suggest that LPS binds NK cells at non-CAM sites, resulting in the release of IFN. IFN then acts in an autocrine manner independent of CAM to enhance NK cytotoxicity. Interaction of anti-CAM antibodies with CAM may provide a negative signal in regulating LPS-induced IFN production.
Interaction of lipopolysaccharide (LPS) from enteric and oral bacteria with natural killer (NK) cells enhanced cytotoxicity against NK-sensitive and NK-resistant targets. This activation occurred without expansion of the NK cell population or without changes in the leukocyte function-associated antigen family of cellular adhesion molecule (CAM) expression on NK cells. Significant interferon (IFN) titers were measured in LPS-lymphocyte supernatants, and antibody to IFN-alpha blocked LPS activation. LPS-induced NK cytotoxicity was inhibited by antibodies to individual alpha chains of CAM and, more profoundly, by antibody to the beta chain of CAM. However, LPS, when preincubated with NK cells, did not compete with subsequent anti-CAM antibody binding as detected by flow cytometry. Anti-CAM antibodies had no effect on NK activation by IFN, but antibodies to either CD11a or CD11c abrogated IFN production induced by LPS. These findings suggest that LPS binds NK cells at non-CAM sites, resulting in the release of IFN. IFN then acts in an autocrine manner independent of CAM to enhance NK cytotoxicity. Interaction of anti-CAM antibodies with CAM may provide a negative signal in regulating LPS-induced IFN production.Interaction of lipopolysaccharide (LPS) from enteric and oral bacteria with natural killer (NK) cells enhanced cytotoxicity against NK-sensitive and NK-resistant targets. This activation occurred without expansion of the NK cell population or without changes in the leukocyte function-associated antigen family of cellular adhesion molecule (CAM) expression on NK cells. Significant interferon (IFN) titers were measured in LPS-lymphocyte supernatants, and antibody to IFN-alpha blocked LPS activation. LPS-induced NK cytotoxicity was inhibited by antibodies to individual alpha chains of CAM and, more profoundly, by antibody to the beta chain of CAM. However, LPS, when preincubated with NK cells, did not compete with subsequent anti-CAM antibody binding as detected by flow cytometry. Anti-CAM antibodies had no effect on NK activation by IFN, but antibodies to either CD11a or CD11c abrogated IFN production induced by LPS. These findings suggest that LPS binds NK cells at non-CAM sites, resulting in the release of IFN. IFN then acts in an autocrine manner independent of CAM to enhance NK cytotoxicity. Interaction of anti-CAM antibodies with CAM may provide a negative signal in regulating LPS-induced IFN production.
Author Lindemann, R A
Author_xml – sequence: 1
  givenname: R A
  surname: Lindemann
  fullname: Lindemann, R A
  organization: School of Dentistry, University of California, Los Angeles 90024
BackLink https://www.ncbi.nlm.nih.gov/pubmed/2470678$$D View this record in MEDLINE/PubMed
BookMark eNotkM1OwzAQhH0oKm3hERA-cUuwXSe2j1XFT6RKSAjOkeusVYPjFDtB4u1xoZfd2d1Po9Eu0SwMARC6paSklMn7ZtOUlSjrkgrCilyyUlLN0IIQqgpV1eISLVP6yCPnXM7RnPFMCblA7nXwkPBgsQsjRAtxCFiHDhvwfvI6Yt0dILm87TNpphPtAt5rk3GnPc7CfevxRGSXw9TrgIMep5hvn857iH9e6QpdWO0TXJ_7Cr0_Prxtn4vdy1Oz3ewKw5UYC2ZtRbqqE5SYHNEoJaiQzDCmdGXXQlHR1VbJrqqpMpTWAMB4zQivBZg1sBW6-_c9xuFrgjS2vUunBDrAMKVWSKUolSSDN2dw2vfQtcfoeh1_2vNv2C-70GhH
CitedBy_id crossref_primary_10_1111_j_1600_0765_1991_tb01799_x
crossref_primary_10_1111_j_1365_2567_2004_01858_x
crossref_primary_10_1111_j_1365_3083_1992_tb03127_x
crossref_primary_10_1111_j_1365_3083_1991_tb02547_x
crossref_primary_10_1111_j_1600_0765_1995_tb02132_x
crossref_primary_10_1016_j_cellimm_2020_104201
crossref_primary_10_3390_ijms25158090
crossref_primary_10_1016_0952_7915_93_90030_V
crossref_primary_10_3389_fcell_2021_734720
ContentType Journal Article
DBID CGR
CUY
CVF
ECM
EIF
NPM
7X8
DOI 10.1128/IAI.57.6.1702-1706.1989
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod no_fulltext_linktorsrc
Discipline Medicine
Biology
ExternalDocumentID 2470678
Genre Journal Article
GroupedDBID ---
-DZ
-~X
.55
.GJ
0R~
18M
29I
2WC
39C
3O-
4.4
41~
53G
5GY
5RE
5VS
85S
ABOCM
ACGFO
ADBBV
AENEX
AGCDD
AGVNZ
AI.
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BTFSW
C1A
CGR
CS3
CUY
CVF
D0S
DIK
DU5
E3Z
EBS
ECM
EIF
EJD
F5P
FRP
GX1
H13
HYE
HZ~
H~9
IH2
J5H
KQ8
L7B
MVM
NEJ
NPM
O9-
OHT
OK1
P2P
PKN
RHF
RHI
RNS
RPM
RSF
SJN
TR2
TWZ
UCJ
UPT
VH1
VQA
W2D
W8F
WH7
WHG
WOQ
X7M
Y6R
YIF
ZGI
ZXP
~KM
7X8
AAGFI
ID FETCH-LOGICAL-c497t-2ff50d5d710c067c9971782c229a5f37917d6f98d5619c116eee24620467ec3e2
IEDL.DBID 7X8
ISICitedReferencesCount 16
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=10.1128/iai.57.6.1702-1706.1989&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 0019-9567
IngestDate Thu Sep 04 17:56:00 EDT 2025
Wed Feb 19 00:46:24 EST 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 6
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c497t-2ff50d5d710c067c9971782c229a5f37917d6f98d5619c116eee24620467ec3e2
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://iai.asm.org/content/iai/57/6/1702.full.pdf
PMID 2470678
PQID 78991180
PQPubID 23479
ParticipantIDs proquest_miscellaneous_78991180
pubmed_primary_2470678
PublicationCentury 1900
PublicationDate 1989-06-01
PublicationDateYYYYMMDD 1989-06-01
PublicationDate_xml – month: 06
  year: 1989
  text: 1989-06-01
  day: 01
PublicationDecade 1980
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Infection and immunity
PublicationTitleAlternate Infect Immun
PublicationYear 1989
References 2895743 - Infect Immun. 1988 May;56(5):1301-8
3093576 - J Immunol. 1986 Oct 15;137(8):2428-33
3130415 - J Dent Res. 1988 May;67(5):846-50
6166701 - J Exp Med. 1981 Mar 1;153(3):569-82
4325022 - Appl Microbiol. 1971 Apr;21(4):723-5
3924996 - J Immunol. 1985 Aug;135(2):1020-5
13712490 - Exp Cell Res. 1961 Feb;23:14-20
3261303 - J Dent Res. 1988 Aug;67(8):1131-5
2408801 - Clin Exp Immunol. 1985 May;60(2):274-84
954005 - Cancer Res. 1976 Oct;36(10):3842-6
3918100 - J Immunol. 1985 Mar;134(3):1493-7
2453465 - Infect Immun. 1988 Jun;56(6):1436-41
7334070 - J Clin Immunol. 1981 Jan;1(1):51-63
3100481 - Hum Immunol. 1987 Jan;18(1):3-37
3537192 - J Exp Med. 1986 Dec 1;164(6):1876-88
6348161 - J Immunol Methods. 1983 Jul 29;61(3):293-300
References_xml – reference: 2895743 - Infect Immun. 1988 May;56(5):1301-8
– reference: 13712490 - Exp Cell Res. 1961 Feb;23:14-20
– reference: 6166701 - J Exp Med. 1981 Mar 1;153(3):569-82
– reference: 3537192 - J Exp Med. 1986 Dec 1;164(6):1876-88
– reference: 4325022 - Appl Microbiol. 1971 Apr;21(4):723-5
– reference: 954005 - Cancer Res. 1976 Oct;36(10):3842-6
– reference: 3261303 - J Dent Res. 1988 Aug;67(8):1131-5
– reference: 6348161 - J Immunol Methods. 1983 Jul 29;61(3):293-300
– reference: 2408801 - Clin Exp Immunol. 1985 May;60(2):274-84
– reference: 3918100 - J Immunol. 1985 Mar;134(3):1493-7
– reference: 3924996 - J Immunol. 1985 Aug;135(2):1020-5
– reference: 7334070 - J Clin Immunol. 1981 Jan;1(1):51-63
– reference: 3093576 - J Immunol. 1986 Oct 15;137(8):2428-33
– reference: 3100481 - Hum Immunol. 1987 Jan;18(1):3-37
– reference: 2453465 - Infect Immun. 1988 Jun;56(6):1436-41
– reference: 3130415 - J Dent Res. 1988 May;67(5):846-50
SSID ssj0014448
Score 1.4177012
Snippet Interaction of lipopolysaccharide (LPS) from enteric and oral bacteria with natural killer (NK) cells enhanced cytotoxicity against NK-sensitive and...
SourceID proquest
pubmed
SourceType Aggregation Database
Index Database
StartPage 1702
SubjectTerms Antibodies, Monoclonal - physiology
Antigens, Bacterial - immunology
Antigens, Surface - analysis
Antigens, Surface - immunology
Binding Sites, Antibody
Binding, Competitive
Cell Adhesion Molecules
Cytotoxicity, Immunologic
Humans
Immune Sera - pharmacology
Interferon Inducers - immunology
Interferons - biosynthesis
Interferons - immunology
Interferons - physiology
Killer Cells, Natural - immunology
Killer Cells, Natural - metabolism
Killer Cells, Natural - microbiology
Lipopolysaccharides - immunology
Lymphocyte Activation
Receptors, Immunologic - analysis
Title Roles of interferon and cellular adhesion molecules in bacterial activation of human natural killer cells
URI https://www.ncbi.nlm.nih.gov/pubmed/2470678
https://www.proquest.com/docview/78991180
Volume 57
WOSCitedRecordID wos10.1128/iai.57.6.1702-1706.1989&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText
inHoldings 1
isFullTextHit
isPrint
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8NAEB6qVfHio1qszz14TW22m90sCCJi8WBLEZXeSroPDGJS2yr4751JUrzpwUtISLJZksnsN7Oz3wdwbqULExGbILKyEwgEFMFEGjrUJgkREvBCDuj5Xg0G8WikhzW4XK6FobLKpU8sHLXNDeXILxQGBkRXdjV9D0gziuZWKwGNFah3EciQTavRzxyCEKLywzrAKEBV1V3okC_SJG1Hqi3boSJtD9XBPR3_gjKL0aa3_b9-7sBWhTLZdWkWu1BzWQPWS93JrwZs9KsZ9T1IH4jRieWeEXHEzLtZnrEks4wy-lSiyhL74iilxt5KJV28Os3YpGR5xofQyogyr0utFJp_rKALxXOvxUrDoq35Pjz1bh9v7oJKfiEwQqtFwL2POjayiEEMjmlGawz9Ym4410nkuwoDPSu9ji1CMG3CUDrnuCB-e6mc6TrehNUsz9wBMKpN4SqeONWZCBm6xGOYJLFVhBdd4U0LzpYvc4zmTb1KMpd_zMfL19mCZvk9xtOShWPMhaKR9vDPW49gsywMo9TJMdQ9_tfuBNbM5yKdz04Lo8HtYNj_Bjz5y7A
linkProvider ProQuest
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Roles+of+interferon+and+cellular+adhesion+molecules+in+bacterial+activation+of+human+natural+killer+cells&rft.jtitle=Infection+and+immunity&rft.au=Lindemann%2C+R+A&rft.date=1989-06-01&rft.issn=0019-9567&rft.volume=57&rft.issue=6&rft.spage=1702&rft_id=info:doi/10.1128%2Fiai.57.6.1702-1706.1989&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0019-9567&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0019-9567&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0019-9567&client=summon