International trends in clozapine use: a study in 17 countries

Objective There is some evidence that clozapine is significantly underutilised. Also, clozapine use is thought to vary by country, but so far no international study has assessed trends in clozapine prescribing. Therefore, this study aimed to assess clozapine use trends on an international scale, usi...

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Vydáno v:	Acta psychiatrica Scandinavica Ročník 136; číslo 1; s. 37 - 51
Hlavní autoři:	Bachmann, C. J., Aagaard, L., Bernardo, M., Brandt, L., Cartabia, M., Clavenna, A., Coma Fusté, A., Furu, K., Garuoliené, K., Hoffmann, F., Hollingworth, S., Huybrechts, K. F., Kalverdijk, L. J., Kawakami, K., Kieler, H., Kinoshita, T., López, S. C., Machado‐Alba, J. E., Machado‐Duque, M. E., Mahesri, M., Nishtala, P. S., Piovani, D., Reutfors, J., Saastamoinen, L. K., Sato, I., Schuiling‐Veninga, C. C. M., Shyu, Y.‐C., Siskind, D., Skurtveit, S., Verdoux, H., Wang, L.‐J., Zara Yahni, C., Zoëga, H., Taylor, D.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Blackwell Publishing Ltd 01.07.2017
Témata:	Adolescent Adult Aged Aged, 80 and over Antipsychotic Agents - therapeutic use Antipsychotics Child Clozapine Clozapine - therapeutic use Cross-Sectional Studies Data processing Drug Prescriptions - statistics & numerical data Drug Utilization - statistics & numerical data Drug Utilization - trends Humans Middle Aged pharmacoepidemiology psychotic disorders Trends Young Adult United States > US Finland psychotic disorders clozapine pharmacoepidemiology
ISSN:	0001-690X, 1600-0447, 1600-0447
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Popis
Shrnutí:	Objective There is some evidence that clozapine is significantly underutilised. Also, clozapine use is thought to vary by country, but so far no international study has assessed trends in clozapine prescribing. Therefore, this study aimed to assess clozapine use trends on an international scale, using standardised criteria for data analysis. Method A repeated cross‐sectional design was applied to data extracts (2005–2014) from 17 countries worldwide. Results In 2014, overall clozapine use prevalence was greatest in Finland (189.2/100 000 persons) and in New Zealand (116.3/100 000), and lowest in the Japanese cohort (0.6/100 000), and in the privately insured US cohort (14.0/100 000). From 2005 to 2014, clozapine use increased in almost all studied countries (relative increase: 7.8–197.2%). In most countries, clozapine use was highest in 40–59‐year‐olds (range: 0.6/100 000 (Japan) to 344.8/100 000 (Finland)). In youths (10–19 years), clozapine use was highest in Finland (24.7/100 000) and in the publicly insured US cohort (15.5/100 000). Conclusion While clozapine use has increased in most studied countries over recent years, clozapine is still underutilised in many countries, with clozapine utilisation patterns differing significantly between countries. Future research should address the implementation of interventions designed to facilitate increased clozapine utilisation.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0001-690X 1600-0447 1600-0447
DOI:	10.1111/acps.12742