Association Between Accelerated Multimorbidity and Age-Related Cognitive Decline in Older Baltimore Longitudinal Study of Aging Participants without Dementia

Objectives To explore the association between rate of physical health deterioration, operationalized as rising multimorbidity overtime, and longitudinal decline in cognitive function in older adults without dementia. Design Longitudinal (Baltimore Longitudinal Study of Aging (BLSA)). Setting Communi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of the American Geriatrics Society (JAGS) Jg. 64; H. 5; S. 965 - 972
Hauptverfasser: Fabbri, Elisa, An, Yang, Zoli, Marco, Tanaka, Toshiko, Simonsick, Eleanor M., Kitner-Triolo, Melissa H., Studenski, Stephanie A., Resnick, Susan M., Ferrucci, Luigi
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Blackwell Publishing Ltd 01.05.2016
Schlagworte:
Aged
aging
Aging - psychology
Baltimore - epidemiology
Chronic Disease - epidemiology
cognition
cognitive decline
Cognitive Dysfunction - psychology
Comorbidity
Female
Health Status Indicators
Humans
Longitudinal Studies
Male
multimorbidity
Neuropsychological Tests
older adults
multimorbidity
older adults
aging
cognition
cognitive decline
ISSN:0002-8614, 1532-5415, 1532-5415
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Objectives To explore the association between rate of physical health deterioration, operationalized as rising multimorbidity overtime, and longitudinal decline in cognitive function in older adults without dementia. Design Longitudinal (Baltimore Longitudinal Study of Aging (BLSA)). Setting Community. Participants BLSA participants aged 65 and older followed for an average of 3 years and free of dementia or mild cognitive impairment (MCI) at baseline and follow‐up (N = 756). Measurements Standardized neurocognitive tests evaluating mental status, memory, executive function, processing speed, and verbal fluency were administered. Multimorbidity was assessed at each visit as number of diagnosed chronic diseases from a predefined list. Faster accumulation of chronic diseases was defined as upper quartile of rate of change in number of diseases over time (≥0.25 diseases/year). Results Faster accumulation of chronic diseases was significantly associated with greater rate of decline on the Category (P = .01) and Letter (P = .01) Fluency Tests. Similar trends were also found for the Trail‐Making Test Parts A (P = .08) and B (P = .07); no association was found with rate of change in visual and verbal memory. Conclusion Although further investigations are required to validate the results and fully understand the underlying mechanisms, these findings suggest that accelerated deterioration of physical health is associated with accelerated decline with aging in specific cognitive domains in older adults without dementia.
Bibliographie:ArticleID:JGS14092
National Institute on Aging (NIA) - No. 03-AG-0325
ark:/67375/WNG-7C9714DW-3
istex:B8E514143886F0773B6D8E3863A11BB26C5BD198
National Institutes of Health
Table S1. Number of Participants According to Years of Follow-Up (N = 756). Table S2. Number of Observations According to Years of Follow-Up (N = 1,963). Table S3. Prevalence of Each Chronic Disease in the Study Population at Baseline. Table S4. Characteristics of Baseline Population According to Cognitive Tests Included in analysis. Table S5. Annual Rate of Change in Number of Chronic Diseases Over Time in Sample Population. Table S6. Sensitivity Analyses Excluding That the Variable Duration of Follow-Up May Have Confounded Interpretation of Results.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0002-8614
1532-5415
1532-5415
DOI:10.1111/jgs.14092