Association Between Accelerated Multimorbidity and Age-Related Cognitive Decline in Older Baltimore Longitudinal Study of Aging Participants without Dementia
Objectives To explore the association between rate of physical health deterioration, operationalized as rising multimorbidity overtime, and longitudinal decline in cognitive function in older adults without dementia. Design Longitudinal (Baltimore Longitudinal Study of Aging (BLSA)). Setting Communi...
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| Published in: | Journal of the American Geriatrics Society (JAGS) Vol. 64; no. 5; pp. 965 - 972 |
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| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Blackwell Publishing Ltd
01.05.2016
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| ISSN: | 0002-8614, 1532-5415, 1532-5415 |
| Online Access: | Get full text |
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| Abstract | Objectives
To explore the association between rate of physical health deterioration, operationalized as rising multimorbidity overtime, and longitudinal decline in cognitive function in older adults without dementia.
Design
Longitudinal (Baltimore Longitudinal Study of Aging (BLSA)).
Setting
Community.
Participants
BLSA participants aged 65 and older followed for an average of 3 years and free of dementia or mild cognitive impairment (MCI) at baseline and follow‐up (N = 756).
Measurements
Standardized neurocognitive tests evaluating mental status, memory, executive function, processing speed, and verbal fluency were administered. Multimorbidity was assessed at each visit as number of diagnosed chronic diseases from a predefined list. Faster accumulation of chronic diseases was defined as upper quartile of rate of change in number of diseases over time (≥0.25 diseases/year).
Results
Faster accumulation of chronic diseases was significantly associated with greater rate of decline on the Category (P = .01) and Letter (P = .01) Fluency Tests. Similar trends were also found for the Trail‐Making Test Parts A (P = .08) and B (P = .07); no association was found with rate of change in visual and verbal memory.
Conclusion
Although further investigations are required to validate the results and fully understand the underlying mechanisms, these findings suggest that accelerated deterioration of physical health is associated with accelerated decline with aging in specific cognitive domains in older adults without dementia. |
|---|---|
| AbstractList | Objectives To explore the association between rate of physical health deterioration, operationalized as rising multimorbidity overtime, and longitudinal decline in cognitive function in older adults without dementia. Design Longitudinal (Baltimore Longitudinal Study of Aging (BLSA)). Setting Community. Participants BLSA participants aged 65 and older followed for an average of 3 years and free of dementia or mild cognitive impairment (MCI) at baseline and follow-up (N = 756). Measurements Standardized neurocognitive tests evaluating mental status, memory, executive function, processing speed, and verbal fluency were administered. Multimorbidity was assessed at each visit as number of diagnosed chronic diseases from a predefined list. Faster accumulation of chronic diseases was defined as upper quartile of rate of change in number of diseases over time ( greater than or equal to 0.25 diseases/year). Results Faster accumulation of chronic diseases was significantly associated with greater rate of decline on the Category (P = .01) and Letter (P = .01) Fluency Tests. Similar trends were also found for the Trail-Making Test Parts A (P = .08) and B (P = .07); no association was found with rate of change in visual and verbal memory. Conclusion Although further investigations are required to validate the results and fully understand the underlying mechanisms, these findings suggest that accelerated deterioration of physical health is associated with accelerated decline with aging in specific cognitive domains in older adults without dementia. Objectives To explore the association between rate of physical health deterioration, operationalized as rising multimorbidity overtime, and longitudinal decline in cognitive function in older adults without dementia. Design Longitudinal (Baltimore Longitudinal Study of Aging (BLSA)). Setting Community. Participants BLSA participants aged 65 and older followed for an average of 3 years and free of dementia or mild cognitive impairment (MCI) at baseline and follow‐up (N = 756). Measurements Standardized neurocognitive tests evaluating mental status, memory, executive function, processing speed, and verbal fluency were administered. Multimorbidity was assessed at each visit as number of diagnosed chronic diseases from a predefined list. Faster accumulation of chronic diseases was defined as upper quartile of rate of change in number of diseases over time (≥0.25 diseases/year). Results Faster accumulation of chronic diseases was significantly associated with greater rate of decline on the Category (P = .01) and Letter (P = .01) Fluency Tests. Similar trends were also found for the Trail‐Making Test Parts A (P = .08) and B (P = .07); no association was found with rate of change in visual and verbal memory. Conclusion Although further investigations are required to validate the results and fully understand the underlying mechanisms, these findings suggest that accelerated deterioration of physical health is associated with accelerated decline with aging in specific cognitive domains in older adults without dementia. To explore the association between rate of physical health deterioration, operationalized as rising multimorbidity overtime, and longitudinal decline in cognitive function in older adults without dementia. Longitudinal (Baltimore Longitudinal Study of Aging (BLSA)). Community. BLSA participants aged 65 and older followed for an average of 3 years and free of dementia or mild cognitive impairment (MCI) at baseline and follow-up (N = 756). Standardized neurocognitive tests evaluating mental status, memory, executive function, processing speed, and verbal fluency were administered. Multimorbidity was assessed at each visit as number of diagnosed chronic diseases from a predefined list. Faster accumulation of chronic diseases was defined as upper quartile of rate of change in number of diseases over time (≥0.25 diseases/year). Faster accumulation of chronic diseases was significantly associated with greater rate of decline on the Category (P = .01) and Letter (P = .01) Fluency Tests. Similar trends were also found for the Trail-Making Test Parts A (P = .08) and B (P = .07); no association was found with rate of change in visual and verbal memory. Although further investigations are required to validate the results and fully understand the underlying mechanisms, these findings suggest that accelerated deterioration of physical health is associated with accelerated decline with aging in specific cognitive domains in older adults without dementia. To explore the association between rate of physical health deterioration, operationalized as rising multimorbidity overtime, and longitudinal decline in cognitive function in older adults without dementia.OBJECTIVESTo explore the association between rate of physical health deterioration, operationalized as rising multimorbidity overtime, and longitudinal decline in cognitive function in older adults without dementia.Longitudinal (Baltimore Longitudinal Study of Aging (BLSA)).DESIGNLongitudinal (Baltimore Longitudinal Study of Aging (BLSA)).Community.SETTINGCommunity.BLSA participants aged 65 and older followed for an average of 3 years and free of dementia or mild cognitive impairment (MCI) at baseline and follow-up (N = 756).PARTICIPANTSBLSA participants aged 65 and older followed for an average of 3 years and free of dementia or mild cognitive impairment (MCI) at baseline and follow-up (N = 756).Standardized neurocognitive tests evaluating mental status, memory, executive function, processing speed, and verbal fluency were administered. Multimorbidity was assessed at each visit as number of diagnosed chronic diseases from a predefined list. Faster accumulation of chronic diseases was defined as upper quartile of rate of change in number of diseases over time (≥0.25 diseases/year).MEASUREMENTSStandardized neurocognitive tests evaluating mental status, memory, executive function, processing speed, and verbal fluency were administered. Multimorbidity was assessed at each visit as number of diagnosed chronic diseases from a predefined list. Faster accumulation of chronic diseases was defined as upper quartile of rate of change in number of diseases over time (≥0.25 diseases/year).Faster accumulation of chronic diseases was significantly associated with greater rate of decline on the Category (P = .01) and Letter (P = .01) Fluency Tests. Similar trends were also found for the Trail-Making Test Parts A (P = .08) and B (P = .07); no association was found with rate of change in visual and verbal memory.RESULTSFaster accumulation of chronic diseases was significantly associated with greater rate of decline on the Category (P = .01) and Letter (P = .01) Fluency Tests. Similar trends were also found for the Trail-Making Test Parts A (P = .08) and B (P = .07); no association was found with rate of change in visual and verbal memory.Although further investigations are required to validate the results and fully understand the underlying mechanisms, these findings suggest that accelerated deterioration of physical health is associated with accelerated decline with aging in specific cognitive domains in older adults without dementia.CONCLUSIONAlthough further investigations are required to validate the results and fully understand the underlying mechanisms, these findings suggest that accelerated deterioration of physical health is associated with accelerated decline with aging in specific cognitive domains in older adults without dementia. |
| Author | Tanaka, Toshiko Resnick, Susan M. Fabbri, Elisa Zoli, Marco An, Yang Simonsick, Eleanor M. Studenski, Stephanie A. Kitner-Triolo, Melissa H. Ferrucci, Luigi |
| Author_xml | – sequence: 1 givenname: Elisa surname: Fabbri fullname: Fabbri, Elisa email: elisa.fabbri@nih.gov organization: Translational Gerontology Branch, Longitudinal Study Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health Baltimore, Baltimore, Maryland – sequence: 2 givenname: Yang surname: An fullname: An, Yang organization: Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland – sequence: 3 givenname: Marco surname: Zoli fullname: Zoli, Marco organization: Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy – sequence: 4 givenname: Toshiko surname: Tanaka fullname: Tanaka, Toshiko organization: Translational Gerontology Branch, Longitudinal Study Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health Baltimore, Baltimore, Maryland – sequence: 5 givenname: Eleanor M. surname: Simonsick fullname: Simonsick, Eleanor M. organization: Translational Gerontology Branch, Longitudinal Study Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health Baltimore, Baltimore, Maryland – sequence: 6 givenname: Melissa H. surname: Kitner-Triolo fullname: Kitner-Triolo, Melissa H. organization: Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland – sequence: 7 givenname: Stephanie A. surname: Studenski fullname: Studenski, Stephanie A. organization: Translational Gerontology Branch, Longitudinal Study Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health Baltimore, Baltimore, Maryland – sequence: 8 givenname: Susan M. surname: Resnick fullname: Resnick, Susan M. organization: Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland – sequence: 9 givenname: Luigi surname: Ferrucci fullname: Ferrucci, Luigi organization: Translational Gerontology Branch, Longitudinal Study Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health Baltimore, Baltimore, Maryland |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27131225$$D View this record in MEDLINE/PubMed |
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| Keywords | multimorbidity older adults aging cognition cognitive decline |
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| Notes | ArticleID:JGS14092 National Institute on Aging (NIA) - No. 03-AG-0325 ark:/67375/WNG-7C9714DW-3 istex:B8E514143886F0773B6D8E3863A11BB26C5BD198 National Institutes of Health Table S1. Number of Participants According to Years of Follow-Up (N = 756). Table S2. Number of Observations According to Years of Follow-Up (N = 1,963). Table S3. Prevalence of Each Chronic Disease in the Study Population at Baseline. Table S4. Characteristics of Baseline Population According to Cognitive Tests Included in analysis. Table S5. Annual Rate of Change in Number of Chronic Diseases Over Time in Sample Population. Table S6. Sensitivity Analyses Excluding That the Variable Duration of Follow-Up May Have Confounded Interpretation of Results. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
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To explore the association between rate of physical health deterioration, operationalized as rising multimorbidity overtime, and longitudinal... To explore the association between rate of physical health deterioration, operationalized as rising multimorbidity overtime, and longitudinal decline in... Objectives To explore the association between rate of physical health deterioration, operationalized as rising multimorbidity overtime, and longitudinal... |
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| SubjectTerms | Aged aging Aging - psychology Baltimore - epidemiology Chronic Disease - epidemiology cognition cognitive decline Cognitive Dysfunction - psychology Comorbidity Female Health Status Indicators Humans Longitudinal Studies Male multimorbidity Neuropsychological Tests older adults |
| Title | Association Between Accelerated Multimorbidity and Age-Related Cognitive Decline in Older Baltimore Longitudinal Study of Aging Participants without Dementia |
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