An immune-based biomarker signature is associated with mortality in COVID-19 patients

Immune and inflammatory responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contribute to disease severity of coronavirus disease 2019 (COVID-19). However, the utility of specific immune-based biomarkers to predict clinical outcome remains elusive. Here, we analyzed levels of 6...

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Bibliographic Details
Published in:	JCI insight Vol. 6; no. 1
Main Authors:	Abers, Michael S., Delmonte, Ottavia M., Ricotta, Emily E., Fintzi, Jonathan, Fink, Danielle L., de Jesus, Adriana A. Almeida, Zarember, Kol A., Alehashemi, Sara, Oikonomou, Vasileios, Desai, Jigar V., Canna, Scott W., Shakoory, Bita, Dobbs, Kerry, Imberti, Luisa, Sottini, Alessandra, Quiros-Roldan, Eugenia, Castelli, Francesco, Rossi, Camillo, Brugnoni, Duilio, Biondi, Andrea, Bettini, Laura Rachele, D’Angio’, Mariella, Bonfanti, Paolo, Castagnoli, Riccardo, Montagna, Daniela, Licari, Amelia, Marseglia, Gian Luigi, Gliniewicz, Emily F., Shaw, Elana, Kahle, Dana E., Rastegar, Andre T., Stack, Michael, Myint-Hpu, Katherine, Levinson, Susan L., DiNubile, Mark J., Chertow, Daniel W., Burbelo, Peter D., Cohen, Jeffrey I., Calvo, Katherine R., Tsang, John S., Su, Helen C., Gallin, John I., Kuhns, Douglas B., Goldbach-Mansky, Raphaela, Lionakis, Michail S., Notarangelo, Luigi D.
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 11.01.2021 American Society for Clinical investigation
Subjects:	Adrenal Cortex Hormones - therapeutic use Adult Aged Anti-Bacterial Agents - therapeutic use Antibodies, Monoclonal, Humanized - therapeutic use Antiviral Agents - therapeutic use Azithromycin - therapeutic use Biomarkers Blood levels Calgranulin B - genetics Calgranulin B - immunology Case-Control Studies Chemokine CCL2 - genetics Chemokine CCL2 - immunology Chemokine CXCL9 - genetics Chemokine CXCL9 - immunology Clinical outcomes Comorbidity Coronaviruses COVID-19 COVID-19 - genetics COVID-19 - immunology COVID-19 - mortality COVID-19 - therapy Diabetes Discordance Enzyme Inhibitors - therapeutic use Female Ferritin Ferritins - genetics Ferritins - immunology Gelatinase B Gene Expression Profiling Hospitalization Humans Hydroxychloroquine - therapeutic use Immunologic Factors - therapeutic use Immunology Infections Inflammation Interferon Type I - genetics Interferon Type I - immunology Interferon-gamma - genetics Interferon-gamma - immunology Interleukin 10 Interleukin 15 Interleukin 2 Interleukin-1 Receptor-Like 1 Protein - genetics Interleukin-1 Receptor-Like 1 Protein - immunology Interleukin-10 - genetics Interleukin-10 - immunology Interleukin-15 - genetics Interleukin-15 - immunology Interleukin-2 - genetics Interleukin-2 - immunology Interleukin-6 - genetics Interleukin-6 - immunology Lactoferrin Lactoferrin - genetics Lactoferrin - immunology Lipocalin-2 - genetics Lipocalin-2 - immunology Male Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - immunology Middle Aged Monocyte chemoattractant protein 1 Mortality Multivariate Analysis Neutrophils NF-kappa B - genetics NF-kappa B - immunology NF-κB protein Patients Pneumonia Prognosis Receptors, Tumor Necrosis Factor, Type I - genetics Receptors, Tumor Necrosis Factor, Type I - immunology SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Steroids Vascular Endothelial Growth Factor Receptor-1 - genetics Vascular Endothelial Growth Factor Receptor-1 - immunology Italy COVID-19 Immunology Cytokines Chemokines
ISSN:	2379-3708, 2379-3708
Online Access:	Get full text
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