Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production

We have previously shown that a loss of stromal Cav-1 is a biomarker of poor prognosis in breast cancers. Mechanistically, a loss of Cav-1 induces the metabolic reprogramming of stromal cells, with increased autophagy/mitophagy, mitochondrial dysfunction and aerobic glycolysis. As a consequence, Cav...

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Bibliographic Details
Published in:	Cell cycle (Georgetown, Tex.) Vol. 11; no. 16; pp. 3019 - 3035
Main Authors:	Guido, Carmela, Whitaker-Menezes, Diana, Capparelli, Claudia, Balliet, Renee, Lin, Zhao, Pestell, Richard G., Howell, Anthony, Aquila, Saveria, Andò, Sebastiano, Martinez-Outschoorn, Ubaldo, Sotgia, Federica, Lisanti, Michael P.
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 15.08.2012 Landes Bioscience
Subjects:	"Pied-Piper of Hamelin" aerobic glycolysis Animals Autocrine Communication autocrine signaling Autophagy Binding Biology Bioscience Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Calcium Cancer cancer associated fibroblast cancer metabolism Caveolin 1 - genetics Caveolin 1 - metabolism Cell Cell Line, Tumor Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cellular Reprogramming Coculture Techniques Cycle Female Fibroblasts - metabolism Fibroblasts - pathology Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Glycolysis Humans Immunohistochemistry Lactic Acid - metabolism Landes Ligands Mice Mice, Nude Mitochondria - genetics Mitochondria - metabolism Mitochondria - pathology mitophagy myofibroblast Neovascularization, Pathologic - metabolism Organogenesis Oxidative Phosphorylation Oxidative Stress Paracrine Communication paracrine signaling Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins Receptors, Transforming Growth Factor beta - genetics Receptors, Transforming Growth Factor beta - metabolism Stromal Cells - metabolism Stromal Cells - pathology TGF beta the field effect Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Tumor Microenvironment tumor stroma Xenograft Model Antitumor Assays
ISSN:	1538-4101, 1551-4005, 1551-4005
Online Access:	Get full text
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