BAL Cell Gene Expression Is Indicative of Outcome and Airway Basal Cell Involvement in Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a fatal disease with a variable and unpredictable course. To determine whether BAL cell gene expression is predictive of survival in IPF. This retrospective study analyzed the BAL transcriptome of three independent IPF cohorts: Freiburg (Germany), Siena (Italy)...

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Bibliographic Details
Published in:	American journal of respiratory and critical care medicine Vol. 199; no. 5; pp. 622 - 630
Main Authors:	Prasse, Antje, Binder, Harald, Schupp, Jonas C., Kayser, Gian, Bargagli, Elena, Jaeger, Benedikt, Hess, Moritz, Rittinghausen, Susanne, Vuga, Louis, Lynn, Heather, Violette, Shelia, Jung, Birgit, Quast, Karsten, Vanaudenaerde, Bart, Xu, Yan, Hohlfeld, Jens M., Krug, Norbert, Herazo-Maya, Jose D., Rottoli, Paola, Wuyts, Wim A., Kaminski, Naftali
Format:	Journal Article
Language:	English
Published:	United States American Thoracic Society 01.03.2019
Subjects:	Age Aged Biopsy Bronchoalveolar Lavage Fluid - cytology Chronic obstructive pulmonary disease Female Flow cytometry Gene Expression Gene Expression Profiling Humans Idiopathic Pulmonary Fibrosis - metabolism Idiopathic Pulmonary Fibrosis - mortality Male Mortality Oligonucleotide Array Sequence Analysis Original Physiology Pneumonia Predictive Value of Tests Proportional Hazards Models Pulmonary fibrosis Respiratory Mucosa - metabolism Retrospective Studies Sarcoidosis Stem cells Survival Analysis Thorax Transplants & implants Belgium Italy Germany biomarker airway basal cells BAL transcriptome IPF
ISSN:	1073-449X, 1535-4970, 1535-4970
Online Access:	Get full text
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