Isoflurane and low-level carbon monoxide exposures increase expression of pro-survival miRNA in neonatal mouse heart

Anesthetics such as isoflurane are known to cause apoptosis in the developing mammalian brain. However, isoflurane may have protective effects on the heart via relieving ischemia and downregulating genes related to apoptosis. Ischemic preconditioning, e.g. through the use of low levels of carbon mon...

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Bibliographic Details
Published in:	Cell stress & chaperones Vol. 26; no. 3; pp. 541 - 548
Main Authors:	Logan, Samantha M., Gupta, Aakriti, Wang, Aili, Levy, Richard J., Storey, Kenneth B.
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer Science + Business Media 01.05.2021 Springer Netherlands Springer Nature B.V
Subjects:	Anesthesia Anesthetics Animals Animals, Newborn Apoptosis Apoptosis - genetics Autophagy Biochemistry Biomedical and Life Sciences Biomedicine Cancer Research Carbon monoxide Carbon Monoxide - metabolism Cell Biology Cell death Contraction Energy balance Exposure Gene Expression - drug effects Heart Heart - drug effects Hypertrophy Hypoxia Immunology Injury prevention Ischemia Isoflurane Isoflurane - pharmacology Mice, Inbred C57BL MicroRNAs MicroRNAs - metabolism miRNA Mortality Myocardial Reperfusion Injury - drug therapy Myocardial Reperfusion Injury - metabolism Neonates Neurosciences ORIGINAL PAPER Oxidative stress Phagocytosis Preconditioning Reperfusion Up-Regulation Oxidative stress MicroRNA Cardioprotective Anesthetic Apoptosis Mus musculus
ISSN:	1355-8145, 1466-1268, 1466-1268
Online Access:	Get full text
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