The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression

TIA1 and TIAL1 encode a family of U-rich element mRNA-binding proteins ubiquitously expressed and conserved in metazoans. Using PAR-CLIP, we determined that both proteins bind target sites with identical specificity in 3' UTRs and introns proximal to 5' as well as 3' splice sites. Dou...

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Veröffentlicht in:	Molecular cell Jg. 69; H. 4; S. 622
Hauptverfasser:	Meyer, Cindy, Garzia, Aitor, Mazzola, Michael, Gerstberger, Stefanie, Molina, Henrik, Tuschl, Thomas
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.02.2018
Schlagworte:	Cell Cycle CRISPR-Cas Systems Cytoplasmic Granules - metabolism eIF-2 Kinase - genetics eIF-2 Kinase - metabolism HEK293 Cells Humans Regulatory Sequences, Ribonucleic Acid RNA Splice Sites RNA Splicing RNA, Double-Stranded - genetics RNA, Double-Stranded - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins - antagonists & inhibitors RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Stress, Physiological T-Cell Intracellular Antigen-1 - antagonists & inhibitors T-Cell Intracellular Antigen-1 - genetics T-Cell Intracellular Antigen-1 - metabolism Uridine - metabolism interferon-inducible double-stranded RNA-dependent protein kinase activator A alternative splicing cell cycle eukaryotic translation initiation factor 2 alpha kinase 2 apoptosis T-cell restricted intracellular antigen-1 integrated stress response
ISSN:	1097-4164, 1097-4164
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