Biomarker-Guided Development of DNA Repair Inhibitors

Anti-cancer drugs targeting the DNA damage response (DDR) exploit genetic or functional defects in this pathway through synthetic lethal mechanisms. For example, defects in homologous recombination (HR) repair arise in cancer cells through inherited or acquired mutations in BRCA1, BRCA2, or other ge...

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Bibliographische Detailangaben
Veröffentlicht in:	Molecular cell Jg. 78; H. 6; S. 1070
Hauptverfasser:	Cleary, James M, Aguirre, Andrew J, Shapiro, Geoffrey I, D'Andrea, Alan D
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 18.06.2020
Schlagworte:	Animals Antineoplastic Agents - therapeutic use Biomarkers, Pharmacological DNA Damage - drug effects DNA End-Joining Repair - drug effects DNA Repair - drug effects DNA Repair - genetics DNA Repair - physiology Genes, BRCA1 - drug effects Homologous Recombination Humans Neoplasms - drug therapy Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Poly(ADP-ribose) Polymerases - metabolism cell-cycle kinases DNA repair polymerase theta PARP inhibitor
ISSN:	1097-4164, 1097-4164
Online-Zugang:	Weitere Angaben
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