Biomarker-Guided Development of DNA Repair Inhibitors

Anti-cancer drugs targeting the DNA damage response (DDR) exploit genetic or functional defects in this pathway through synthetic lethal mechanisms. For example, defects in homologous recombination (HR) repair arise in cancer cells through inherited or acquired mutations in BRCA1, BRCA2, or other ge...

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Bibliographic Details
Published in:	Molecular cell Vol. 78; no. 6; p. 1070
Main Authors:	Cleary, James M, Aguirre, Andrew J, Shapiro, Geoffrey I, D'Andrea, Alan D
Format:	Journal Article
Language:	English
Published:	United States 18.06.2020
Subjects:	Animals Antineoplastic Agents - therapeutic use Biomarkers, Pharmacological DNA Damage - drug effects DNA End-Joining Repair - drug effects DNA Repair - drug effects DNA Repair - genetics DNA Repair - physiology Genes, BRCA1 - drug effects Homologous Recombination Humans Neoplasms - drug therapy Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Poly(ADP-ribose) Polymerases - metabolism cell-cycle kinases DNA repair polymerase theta PARP inhibitor
ISSN:	1097-4164, 1097-4164
Online Access:	Get more information
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