Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis

BACKGROUNDElevated levels of inflammatory cytokines have been associated with poor outcomes among COVID-19 patients. It is unknown, however, how these levels compare with those observed in critically ill patients with acute respiratory distress syndrome (ARDS) or sepsis due to other causes.METHODSWe...

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Vydáno v:	JCI insight Ročník 5; číslo 17
Hlavní autoři:	Wilson, Jennifer G., Simpson, Laura J., Ferreira, Anne-Maud, Rustagi, Arjun, Roque, Jonasel, Asuni, Adijat, Ranganath, Thanmayi, Grant, Philip M., Subramanian, Aruna, Rosenberg-Hasson, Yael, Maecker, Holden T., Holmes, Susan P., Levitt, Joseph E., Blish, Catherine A., Rogers, Angela J.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States American Society for Clinical Investigation 03.09.2020 American Society for Clinical investigation
Témata:	Adult Aged Biomarkers Case-Control Studies Clinical Medicine Coronavirus Infections - blood Coronavirus Infections - immunology COVID-19 Cytokine Release Syndrome - blood Cytokine Release Syndrome - immunology Cytokine storm Cytokines - blood Cytokines - immunology Disease Female Hospitalization Humans IL-1β Immunosuppressive agents Infectious diseases Inflammation Interleukin 1 receptor antagonist Interleukin 1 Receptor Antagonist Protein - blood Interleukin 1 Receptor Antagonist Protein - immunology Interleukin 1 receptors Interleukin 18 Interleukin 6 Interleukin 8 Interleukin-18 - blood Interleukin-18 - immunology Interleukin-1beta - blood Interleukin-1beta - immunology Interleukin-6 - blood Interleukin-6 - immunology Interleukin-8 - blood Interleukin-8 - immunology Male Middle Aged Pandemics Patients Plasma Pneumonia, Viral - blood Pneumonia, Viral - immunology Respiratory distress syndrome Respiratory Distress Syndrome - blood Respiratory Distress Syndrome - immunology Sepsis Sepsis - blood Sepsis - immunology Severity of Illness Index Statistical analysis Tumor Necrosis Factor-alpha - blood Tumor Necrosis Factor-alpha - immunology Tumor necrosis factor-α Ventilation Ventilators COVID-19 Cytokines Inflammation
ISSN:	2379-3708, 2379-3708
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Shrnutí:	BACKGROUNDElevated levels of inflammatory cytokines have been associated with poor outcomes among COVID-19 patients. It is unknown, however, how these levels compare with those observed in critically ill patients with acute respiratory distress syndrome (ARDS) or sepsis due to other causes.METHODSWe used a Luminex assay to determine expression of 76 cytokines from plasma of hospitalized COVID-19 patients and banked plasma samples from ARDS and sepsis patients. Our analysis focused on detecting statistical differences in levels of 6 cytokines associated with cytokine storm (IL-1β, IL-1RA, IL-6, IL-8, IL-18, and TNF-α) between patients with moderate COVID-19, severe COVID-19, and ARDS or sepsis.RESULTSFifteen hospitalized COVID-19 patients, 9 of whom were critically ill, were compared with critically ill patients with ARDS (n = 12) or sepsis (n = 16). There were no statistically significant differences in baseline levels of IL-1β, IL-1RA, IL-6, IL-8, IL-18, and TNF-α between patients with COVID-19 and critically ill controls with ARDS or sepsis.CONCLUSIONLevels of inflammatory cytokines were not higher in severe COVID-19 patients than in moderate COVID-19 or critically ill patients with ARDS or sepsis in this small cohort. Broad use of immunosuppressive therapies in ARDS has failed in numerous Phase 3 studies; use of these therapies in unselected patients with COVID-19 may be unwarranted.FUNDINGFunding was received from NHLBI K23 HL125663 (AJR); The Bill and Melinda Gates Foundation OPP1113682 (AJR and CAB); Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Diseases #1016687 NIH/NIAID U19AI057229-16; Stanford Maternal Child Health Research Institute; and Chan Zuckerberg Biohub (CAB).
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Authorship note: JGW, LJS, and AMF are co–first authors.
ISSN:	2379-3708 2379-3708
DOI:	10.1172/jci.insight.140289