High-throughput sequencing technologies

The human genome sequence has profoundly altered our understanding of biology, human diversity, and disease. The path from the first draft sequence to our nascent era of personal genomes and genomic medicine has been made possible only because of the extraordinary advancements in DNA sequencing tech...

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Veröffentlicht in:Molecular cell Jg. 58; H. 4; S. 586
Hauptverfasser: Reuter, Jason A, Spacek, Damek V, Snyder, Michael P
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 21.05.2015
Schlagworte:
Genome, Human - genetics
Genomics - methods
High-Throughput Nucleotide Sequencing - methods
Humans
Microbiota - genetics
Neoplasms - genetics
Precision Medicine - methods
Transcriptome - genetics
ISSN:1097-4164, 1097-4164
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Zusammenfassung:The human genome sequence has profoundly altered our understanding of biology, human diversity, and disease. The path from the first draft sequence to our nascent era of personal genomes and genomic medicine has been made possible only because of the extraordinary advancements in DNA sequencing technologies over the past 10 years. Here, we discuss commonly used high-throughput sequencing platforms, the growing array of sequencing assays developed around them, as well as the challenges facing current sequencing platforms and their clinical application.
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ISSN:1097-4164
1097-4164
DOI:10.1016/j.molcel.2015.05.004