High-throughput sequencing technologies

The human genome sequence has profoundly altered our understanding of biology, human diversity, and disease. The path from the first draft sequence to our nascent era of personal genomes and genomic medicine has been made possible only because of the extraordinary advancements in DNA sequencing tech...

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Veröffentlicht in:	Molecular cell Jg. 58; H. 4; S. 586
Hauptverfasser:	Reuter, Jason A, Spacek, Damek V, Snyder, Michael P
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 21.05.2015
Schlagworte:	Genome, Human - genetics Genomics - methods High-Throughput Nucleotide Sequencing - methods Humans Microbiota - genetics Neoplasms - genetics Precision Medicine - methods Transcriptome - genetics
ISSN:	1097-4164, 1097-4164
Online-Zugang:	Weitere Angaben
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Abstract	The human genome sequence has profoundly altered our understanding of biology, human diversity, and disease. The path from the first draft sequence to our nascent era of personal genomes and genomic medicine has been made possible only because of the extraordinary advancements in DNA sequencing technologies over the past 10 years. Here, we discuss commonly used high-throughput sequencing platforms, the growing array of sequencing assays developed around them, as well as the challenges facing current sequencing platforms and their clinical application.
AbstractList	The human genome sequence has profoundly altered our understanding of biology, human diversity, and disease. The path from the first draft sequence to our nascent era of personal genomes and genomic medicine has been made possible only because of the extraordinary advancements in DNA sequencing technologies over the past 10 years. Here, we discuss commonly used high-throughput sequencing platforms, the growing array of sequencing assays developed around them, as well as the challenges facing current sequencing platforms and their clinical application. The human genome sequence has profoundly altered our understanding of biology, human diversity, and disease. The path from the first draft sequence to our nascent era of personal genomes and genomic medicine has been made possible only because of the extraordinary advancements in DNA sequencing technologies over the past 10 years. Here, we discuss commonly used high-throughput sequencing platforms, the growing array of sequencing assays developed around them, as well as the challenges facing current sequencing platforms and their clinical application.The human genome sequence has profoundly altered our understanding of biology, human diversity, and disease. The path from the first draft sequence to our nascent era of personal genomes and genomic medicine has been made possible only because of the extraordinary advancements in DNA sequencing technologies over the past 10 years. Here, we discuss commonly used high-throughput sequencing platforms, the growing array of sequencing assays developed around them, as well as the challenges facing current sequencing platforms and their clinical application.
Author	Reuter, Jason A Spacek, Damek V Snyder, Michael P
Author_xml	– sequence: 1 givenname: Jason A surname: Reuter fullname: Reuter, Jason A organization: Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA – sequence: 2 givenname: Damek V surname: Spacek fullname: Spacek, Damek V organization: Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA – sequence: 3 givenname: Michael P surname: Snyder fullname: Snyder, Michael P email: mpsnyder@stanford.edu organization: Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: mpsnyder@stanford.edu
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/26000844$$D View this record in MEDLINE/PubMed
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Snippet	The human genome sequence has profoundly altered our understanding of biology, human diversity, and disease. The path from the first draft sequence to our...
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SubjectTerms	Genome, Human - genetics Genomics - methods High-Throughput Nucleotide Sequencing - methods Humans Microbiota - genetics Neoplasms - genetics Precision Medicine - methods Transcriptome - genetics
Title	High-throughput sequencing technologies
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