R-Loops as Cellular Regulators and Genomic Threats

During transcription, the nascent RNA strand can base pair with its template DNA, displacing the non-template strand as ssDNA and forming a structure called an R-loop. R-loops are common across many domains of life and cause DNA damage in certain contexts. In this review, we summarize recent results...

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Bibliographic Details
Published in:	Molecular cell Vol. 73; no. 3; p. 398
Main Authors:	Crossley, Madzia P, Bocek, Michael, Cimprich, Karlene A
Format:	Journal Article
Language:	English
Published:	United States 07.02.2019
Subjects:	Animals Cell Nucleus - physiology DNA - chemistry DNA - genetics DNA - metabolism DNA Damage DNA Repair Gene Expression Regulation Genome Genomic Instability Humans Nucleic Acid Conformation Nucleic Acid Heteroduplexes - chemistry Nucleic Acid Heteroduplexes - genetics Nucleic Acid Heteroduplexes - metabolism RNA - chemistry RNA - genetics RNA - metabolism Structure-Activity Relationship Transcription, Genetic
ISSN:	1097-4164, 1097-4164
Online Access:	Get more information
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