Identification of novel RNA design candidates by clustering the extended RNA-As-Graphs library

We re-evaluate our RNA-As-Graphs clustering approach, using our expanded graph library and new RNA structures, to identify potential RNA-like topologies for design. Our coarse-grained approach represents RNA secondary structures as tree and dual graphs, with vertices and edges corresponding to RNA h...

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Bibliographic Details
Published in:	Biochimica et biophysica acta. General subjects Vol. 1864; no. 6; p. 129534
Main Authors:	Jain, Swati, Zhu, Qiyao, Paz, Amiel S.P., Schlick, Tamar
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.06.2020
Subjects:	Algorithms Cluster Analysis Computational Biology Databases, Factual Gene Library Graph clustering graphs Humans Linear Models Models, Molecular Nucleic Acid Conformation RAG-3D database regression analysis RNA RNA - genetics RNA - ultrastructure RNA design RNA-like motifs topology Tree and dual graph topologies Graph clustering F-RAG Tree and dual graph topologies RAG-3D database RNA design RNA RNA-like motifs LOO PDB PCA RAG-IF 3D 2D k-NN RAG PAM MSE
ISSN:	0304-4165, 1872-8006, 1872-8006
Online Access:	Get full text
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